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Vascular deterioration in cirrhosis: the big picture.
J Clin Gastroenterol. 2007 Nov-Dec; 41 Suppl 3:S247-53.JC

Abstract

Cirrhosis is characterized by marked abnormalities in the hepatic circulation. Functionally, there is an increased vascular tone and impaired flow-mediated vasorelaxation, whereas anatomically there is sinusoidal remodeling and capillarization, angiogenesis, venous thrombosis, and vascular distortion, all contributing to increase hepatic vascular resistance and portal hypertension. However, vascular changes are not limited to the liver, but are also present in the splanchnic organs, heart, lungs, kidney, brain, and skin. Advances in the knowledge of the mechanisms of these abnormalities have disclosed new targets for therapy and ultimately improved survival.

Authors+Show Affiliations

Bosch J
Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic-Idibaps, University of Barcelona and Centro de Investigación Biomédica de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain. jbosch@clinic.ub.es

MeSH

AnimalsAntihypertensive AgentsCerebrovascular CirculationCollateral CirculationCoronary CirculationDisease ProgressionEndothelium, VascularExtracellular MatrixHumansHypertension, PortalInflammationInsulin ResistanceLiverLiver CirculationLiver CirrhosisNeovascularization, PathologicOxidative StressPortal PressurePulmonary CirculationRenal CirculationSkinSplanchnic CirculationTreatment OutcomeVascular ResistanceVasodilation

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17975472

Citation

Bosch, Jaime. "Vascular Deterioration in Cirrhosis: the Big Picture." Journal of Clinical Gastroenterology, vol. 41 Suppl 3, 2007, pp. S247-53.
Bosch J. Vascular deterioration in cirrhosis: the big picture. J Clin Gastroenterol. 2007;41 Suppl 3:S247-53.
Bosch, J. (2007). Vascular deterioration in cirrhosis: the big picture. Journal of Clinical Gastroenterology, 41 Suppl 3, S247-53.
Bosch J. Vascular Deterioration in Cirrhosis: the Big Picture. J Clin Gastroenterol. 2007 Nov-Dec;41 Suppl 3:S247-53. PubMed PMID: 17975472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular deterioration in cirrhosis: the big picture. A1 - Bosch,Jaime, PY - 2007/12/6/pubmed PY - 2008/2/7/medline PY - 2007/12/6/entrez SP - S247 EP - 53 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 41 Suppl 3 N2 - Cirrhosis is characterized by marked abnormalities in the hepatic circulation. Functionally, there is an increased vascular tone and impaired flow-mediated vasorelaxation, whereas anatomically there is sinusoidal remodeling and capillarization, angiogenesis, venous thrombosis, and vascular distortion, all contributing to increase hepatic vascular resistance and portal hypertension. However, vascular changes are not limited to the liver, but are also present in the splanchnic organs, heart, lungs, kidney, brain, and skin. Advances in the knowledge of the mechanisms of these abnormalities have disclosed new targets for therapy and ultimately improved survival. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/17975472/Vascular_deterioration_in_cirrhosis:_the_big_picture_ DB - PRIME DP - Unbound Medicine ER -