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Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress.
Life Sci. 2007 Nov 10; 81(21-22):1489-95.LS

Abstract

The present study was designed to investigate whether electroacupuncture (EA) was beneficial to extenuate the behavioral deficit in a rat model of depression induced by chronic unpredictable stress (CUS) and to observe the effect of EA on progenitor cell proliferation in the dentate gyrus (DG) of hippocampus. EA was performed on acupoints "Bai-Hui" (Du 20) and unilateral "An-Mian" (EX 17) once daily for 3 consecutive weeks, 2 weeks post CUS procedure. Open field test and forced swimming test were employed to evaluate the behavioral activity during a stress period or EA treatment. The results revealed that exposure to CUS resulted in a decrease of behavioral activity, whilst a daily session of EA treatment significantly reversed the behavioral deficit of these depression model rats. Moreover, as shown by 5-bromo-2-deoxyuridine (BrdU) labeling immunohistochemistry, hippocampal progenitor cell proliferation was decreased in the DG of depression model rats. Intriguingly, EA treatment effectively blocked this decrease. The study demonstrated a potential antidepressant-like effect of EA treatment on CUS induced depression model rats, which might be mediated by up-regulating the hippocampal progenitor cell proliferation.

Authors+Show Affiliations

Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine, Institutes of Brain Science, Fudan University, Shanghai 200032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17976657

Citation

Liu, Qiong, et al. "Electroacupuncture Attenuates the Decrease of Hippocampal Progenitor Cell Proliferation in the Adult Rats Exposed to Chronic Unpredictable Stress." Life Sciences, vol. 81, no. 21-22, 2007, pp. 1489-95.
Liu Q, Yu J, Mi WL, et al. Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. Life Sci. 2007;81(21-22):1489-95.
Liu, Q., Yu, J., Mi, W. L., Mao-Ying, Q. L., Yang, R., Wang, Y. Q., & Wu, G. C. (2007). Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. Life Sciences, 81(21-22), 1489-95.
Liu Q, et al. Electroacupuncture Attenuates the Decrease of Hippocampal Progenitor Cell Proliferation in the Adult Rats Exposed to Chronic Unpredictable Stress. Life Sci. 2007 Nov 10;81(21-22):1489-95. PubMed PMID: 17976657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. AU - Liu,Qiong, AU - Yu,Jin, AU - Mi,Wen-Li, AU - Mao-Ying,Qi-Liang, AU - Yang,Ru, AU - Wang,Yan-Qing, AU - Wu,Gen-Cheng, Y1 - 2007/09/12/ PY - 2007/03/28/received PY - 2007/07/18/revised PY - 2007/08/24/accepted PY - 2007/11/3/pubmed PY - 2008/1/10/medline PY - 2007/11/3/entrez SP - 1489 EP - 95 JF - Life sciences JO - Life Sci VL - 81 IS - 21-22 N2 - The present study was designed to investigate whether electroacupuncture (EA) was beneficial to extenuate the behavioral deficit in a rat model of depression induced by chronic unpredictable stress (CUS) and to observe the effect of EA on progenitor cell proliferation in the dentate gyrus (DG) of hippocampus. EA was performed on acupoints "Bai-Hui" (Du 20) and unilateral "An-Mian" (EX 17) once daily for 3 consecutive weeks, 2 weeks post CUS procedure. Open field test and forced swimming test were employed to evaluate the behavioral activity during a stress period or EA treatment. The results revealed that exposure to CUS resulted in a decrease of behavioral activity, whilst a daily session of EA treatment significantly reversed the behavioral deficit of these depression model rats. Moreover, as shown by 5-bromo-2-deoxyuridine (BrdU) labeling immunohistochemistry, hippocampal progenitor cell proliferation was decreased in the DG of depression model rats. Intriguingly, EA treatment effectively blocked this decrease. The study demonstrated a potential antidepressant-like effect of EA treatment on CUS induced depression model rats, which might be mediated by up-regulating the hippocampal progenitor cell proliferation. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/17976657/Electroacupuncture_attenuates_the_decrease_of_hippocampal_progenitor_cell_proliferation_in_the_adult_rats_exposed_to_chronic_unpredictable_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(07)00625-X DB - PRIME DP - Unbound Medicine ER -