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Release of protein S100B in haemorrhagic shock: effects of small volume resuscitation combined with arginine vasopressin.
Resuscitation. 2008 Mar; 76(3):449-56.R

Abstract

BACKGROUND

The present study was designed to evaluate the effect of conventional fluid resuscitation and small volume resuscitation alone and combined with arginine vasopressin (AVP) on cerebral perfusion pressure (CPP) and protein S100B during experimental haemorrhagic shock.

MATERIAL AND METHODS

Thirty anaesthetised pigs underwent a penetrating liver trauma. Following haemodynamic decompensation, pigs received either (1) a combination of crystalloid (40 mL kg(-1)) and colloid (20 mL kg(-1)) solutions (fluid, n=10), (2) hypertonic-hyperoncotic solution (HHS; 4 mL kg(-1)) combined with normal saline (HHS+NS; n=10) or (3) HHS combined with AVP (0.2 U kg(-1) followed by an infusion of 2 U kg(-1)h(-1); HHS+AVP; n=10).

RESULTS

Compared to baseline, CPP decreased and S100B levels increased significantly at haemodynamic decompensation (S100B: fluid, 0.52+/-0.23 microg L(-1) vs. 0.85+/-0.37 microg L(-1), p<0.05; HHS+NS, 0.47+/-0.18 microg L(-1) vs. 0.90+/-0.33 microg L(-1), p<0.05; HHS+AVP, 0.53+/-0.18 microg L(-1) vs. 0.90+/-0.39 microg L(-1), p<0.01). During the initial 10 min of therapy, CPP of HHS+NS was significantly higher compared to the fluid group, increased more rapidly in the HHS+AVP group, but was not significantly different thereafter. S100B levels decreased close to baseline values (p<0.001), and did not differ between groups.

CONCLUSION

HHS+AVP resulted in higher CPP compared to fluid and HHS+NS in the initial phase of therapy, but did not differ thereafter. Haemorrhage-induced hypotension yielded increased S100B levels that were comparable in groups throughout the study period.

Authors+Show Affiliations

Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany. meybohm@anaesthesie.uni-kiel.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17976887

Citation

Meybohm, Patrick, et al. "Release of Protein S100B in Haemorrhagic Shock: Effects of Small Volume Resuscitation Combined With Arginine Vasopressin." Resuscitation, vol. 76, no. 3, 2008, pp. 449-56.
Meybohm P, Cavus E, Dörges V, et al. Release of protein S100B in haemorrhagic shock: effects of small volume resuscitation combined with arginine vasopressin. Resuscitation. 2008;76(3):449-56.
Meybohm, P., Cavus, E., Dörges, V., Weber, B., Stadlbauer, K. H., Wenzel, V., Scholz, J., Steffen, M., & Bein, B. (2008). Release of protein S100B in haemorrhagic shock: effects of small volume resuscitation combined with arginine vasopressin. Resuscitation, 76(3), 449-56.
Meybohm P, et al. Release of Protein S100B in Haemorrhagic Shock: Effects of Small Volume Resuscitation Combined With Arginine Vasopressin. Resuscitation. 2008;76(3):449-56. PubMed PMID: 17976887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Release of protein S100B in haemorrhagic shock: effects of small volume resuscitation combined with arginine vasopressin. AU - Meybohm,Patrick, AU - Cavus,Erol, AU - Dörges,Volker, AU - Weber,Bernd, AU - Stadlbauer,Karl-Heinz, AU - Wenzel,Volker, AU - Scholz,Jens, AU - Steffen,Martin, AU - Bein,Berthold, Y1 - 2007/10/31/ PY - 2007/06/05/received PY - 2007/08/21/revised PY - 2007/09/05/accepted PY - 2007/11/3/pubmed PY - 2008/6/5/medline PY - 2007/11/3/entrez SP - 449 EP - 56 JF - Resuscitation JO - Resuscitation VL - 76 IS - 3 N2 - BACKGROUND: The present study was designed to evaluate the effect of conventional fluid resuscitation and small volume resuscitation alone and combined with arginine vasopressin (AVP) on cerebral perfusion pressure (CPP) and protein S100B during experimental haemorrhagic shock. MATERIAL AND METHODS: Thirty anaesthetised pigs underwent a penetrating liver trauma. Following haemodynamic decompensation, pigs received either (1) a combination of crystalloid (40 mL kg(-1)) and colloid (20 mL kg(-1)) solutions (fluid, n=10), (2) hypertonic-hyperoncotic solution (HHS; 4 mL kg(-1)) combined with normal saline (HHS+NS; n=10) or (3) HHS combined with AVP (0.2 U kg(-1) followed by an infusion of 2 U kg(-1)h(-1); HHS+AVP; n=10). RESULTS: Compared to baseline, CPP decreased and S100B levels increased significantly at haemodynamic decompensation (S100B: fluid, 0.52+/-0.23 microg L(-1) vs. 0.85+/-0.37 microg L(-1), p<0.05; HHS+NS, 0.47+/-0.18 microg L(-1) vs. 0.90+/-0.33 microg L(-1), p<0.05; HHS+AVP, 0.53+/-0.18 microg L(-1) vs. 0.90+/-0.39 microg L(-1), p<0.01). During the initial 10 min of therapy, CPP of HHS+NS was significantly higher compared to the fluid group, increased more rapidly in the HHS+AVP group, but was not significantly different thereafter. S100B levels decreased close to baseline values (p<0.001), and did not differ between groups. CONCLUSION: HHS+AVP resulted in higher CPP compared to fluid and HHS+NS in the initial phase of therapy, but did not differ thereafter. Haemorrhage-induced hypotension yielded increased S100B levels that were comparable in groups throughout the study period. SN - 0300-9572 UR - https://www.unboundmedicine.com/medline/citation/17976887/Release_of_protein_S100B_in_haemorrhagic_shock:_effects_of_small_volume_resuscitation_combined_with_arginine_vasopressin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-9572(07)00489-3 DB - PRIME DP - Unbound Medicine ER -