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Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels.
Br J Nutr. 2008 May; 99(5):1083-8.BJ

Abstract

Consumption of long-chain n-3 PUFA, particularly DHA, has been shown to improve cardiovascular risk factors but the intake required to achieve benefits is unclear. We sought to determine the relationship between DHA intake, increases in erythrocyte DHA content and changes in blood lipids. A total of sixty-seven subjects (thirty-six male, thirty-one female, mean age 53 years) with fasting serum TAG > or = 1.1 mmol/l and BMI>25 kg/m(2) completed a 12-week, randomized, double-blind, placebo-controlled parallel intervention. Subjects consumed 2, 4 or 6 g/d of DHA-rich fish oil (26 % DHA, 6 % EPA) or a placebo (Sunola oil). Fasting blood lipid concentrations and fatty acid profiles in erythrocyte membranes were assessed at baseline and after 6 and 12 weeks. For every 1 g/d increase in DHA intake, there was a 23 % reduction in TAG (mean baseline concentration 1.9 (sem 0.1) mmol/l), 4.4 % increase in HDL-cholesterol and 7.1 % increase in LDL-cholesterol. Erythrocyte DHA content increased in proportion to the dose of DHA consumed (r 0.72, P < 0.001) and the increase after 12 weeks was linearly related to reductions in TAG (r - 0.38, P < 0.01) and increases in total cholesterol (r 0.39, P < 0.01), LDL-cholesterol (r 0.33, P < 0.01) and HDL-cholesterol (r 0.30, P = 0.02). The close association between incorporation of DHA in erythrocytes and its effects on serum lipids highlights the importance of erythrocyte DHA as an indicator of cardiovascular health status.

Authors+Show Affiliations

Nutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, University of South Australia, Adelaide, SA, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17977469

Citation

Milte, Catherine M., et al. "Dose-dependent Effects of Docosahexaenoic Acid-rich Fish Oil On Erythrocyte Docosahexaenoic Acid and Blood Lipid Levels." The British Journal of Nutrition, vol. 99, no. 5, 2008, pp. 1083-8.
Milte CM, Coates AM, Buckley JD, et al. Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. Br J Nutr. 2008;99(5):1083-8.
Milte, C. M., Coates, A. M., Buckley, J. D., Hill, A. M., & Howe, P. R. (2008). Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. The British Journal of Nutrition, 99(5), 1083-8.
Milte CM, et al. Dose-dependent Effects of Docosahexaenoic Acid-rich Fish Oil On Erythrocyte Docosahexaenoic Acid and Blood Lipid Levels. Br J Nutr. 2008;99(5):1083-8. PubMed PMID: 17977469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. AU - Milte,Catherine M, AU - Coates,Alison M, AU - Buckley,Jonathan D, AU - Hill,Alison M, AU - Howe,Peter R C, Y1 - 2007/10/31/ PY - 2007/11/6/pubmed PY - 2009/3/4/medline PY - 2007/11/6/entrez SP - 1083 EP - 8 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 99 IS - 5 N2 - Consumption of long-chain n-3 PUFA, particularly DHA, has been shown to improve cardiovascular risk factors but the intake required to achieve benefits is unclear. We sought to determine the relationship between DHA intake, increases in erythrocyte DHA content and changes in blood lipids. A total of sixty-seven subjects (thirty-six male, thirty-one female, mean age 53 years) with fasting serum TAG > or = 1.1 mmol/l and BMI>25 kg/m(2) completed a 12-week, randomized, double-blind, placebo-controlled parallel intervention. Subjects consumed 2, 4 or 6 g/d of DHA-rich fish oil (26 % DHA, 6 % EPA) or a placebo (Sunola oil). Fasting blood lipid concentrations and fatty acid profiles in erythrocyte membranes were assessed at baseline and after 6 and 12 weeks. For every 1 g/d increase in DHA intake, there was a 23 % reduction in TAG (mean baseline concentration 1.9 (sem 0.1) mmol/l), 4.4 % increase in HDL-cholesterol and 7.1 % increase in LDL-cholesterol. Erythrocyte DHA content increased in proportion to the dose of DHA consumed (r 0.72, P < 0.001) and the increase after 12 weeks was linearly related to reductions in TAG (r - 0.38, P < 0.01) and increases in total cholesterol (r 0.39, P < 0.01), LDL-cholesterol (r 0.33, P < 0.01) and HDL-cholesterol (r 0.30, P = 0.02). The close association between incorporation of DHA in erythrocytes and its effects on serum lipids highlights the importance of erythrocyte DHA as an indicator of cardiovascular health status. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17977469/Dose_dependent_effects_of_docosahexaenoic_acid_rich_fish_oil_on_erythrocyte_docosahexaenoic_acid_and_blood_lipid_levels_ L2 - https://www.cambridge.org/core/product/identifier/S000711450785344X/type/journal_article DB - PRIME DP - Unbound Medicine ER -