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[Fortified antibiotic (vancomycin, amikacin and ceftazidime) eye drop stability assessment at -20 degrees C].
J Fr Ophtalmol. 2007 Oct; 30(8):807-13.JF

Abstract

INTRODUCTION

Fortified antibiotic ophthalmic solutions are regularly administered as an immediate treatment for bacterial keratitis. Fortified antibiotics used to be self-prepared by nurses. To solve this problem, pharmacy staff studied the stability of three 5% solutions of vancomycin, amikacin, and ceftazidime prepared in aseptic conditions from parenteral antibiotic solutions.

MATERIAL AND METHODS

Solutions were frozen at -20 degrees C. Each solution were examined before storage and over a 75-day period. Ceftazidime and amikacin were diluted in 0.9% sodium chloride and vancomycin in 5% dextrose. Over a 75-day period, physical and pharmacological (absorbance spectra) properties and the sterility of each stock solution were studied.

RESULTS

The pH of amikacin (6.51), ceftazidime (6.47), and vancomycin (3.77) remained stable during the 75-day period. Osmolarities also remained stable (367, 488, and 351 mOsm/L, respectively). There were no significant differences in the concentration, osmolarity, and pH of the three antibiotic solutions before storage and after 75 days of freezing. Over a 75-day period, the stability of amikacin, ceftazidime, and vancomycin remained constant; no contamination was detected before storage and after 75 days.

CONCLUSION

Topical fortified antibiotic solutions can be stored for 75 days at -20 degrees C (15 days quarantine). After this time, these eye-drops should be stored at 4 degrees C and should be discarded after 3 days.

Authors+Show Affiliations

Pharmacie Hospitalière, Centre Hospitalier Universitaire, Caen. chedru-v@chu-caen.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

17978677

Citation

Chédru-Legros, V, et al. "[Fortified Antibiotic (vancomycin, Amikacin and Ceftazidime) Eye Drop Stability Assessment at -20 Degrees C]." Journal Francais D'ophtalmologie, vol. 30, no. 8, 2007, pp. 807-13.
Chédru-Legros V, Fines-Guyon M, Chérel A, et al. [Fortified antibiotic (vancomycin, amikacin and ceftazidime) eye drop stability assessment at -20 degrees C]. J Fr Ophtalmol. 2007;30(8):807-13.
Chédru-Legros, V., Fines-Guyon, M., Chérel, A., Perdriel, A., Albessard, F., Debruyne, D., & Mouriaux, F. (2007). [Fortified antibiotic (vancomycin, amikacin and ceftazidime) eye drop stability assessment at -20 degrees C]. Journal Francais D'ophtalmologie, 30(8), 807-13.
Chédru-Legros V, et al. [Fortified Antibiotic (vancomycin, Amikacin and Ceftazidime) Eye Drop Stability Assessment at -20 Degrees C]. J Fr Ophtalmol. 2007;30(8):807-13. PubMed PMID: 17978677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fortified antibiotic (vancomycin, amikacin and ceftazidime) eye drop stability assessment at -20 degrees C]. AU - Chédru-Legros,V, AU - Fines-Guyon,M, AU - Chérel,A, AU - Perdriel,A, AU - Albessard,F, AU - Debruyne,D, AU - Mouriaux,F, PY - 2007/11/6/pubmed PY - 2007/12/15/medline PY - 2007/11/6/entrez SP - 807 EP - 13 JF - Journal francais d'ophtalmologie JO - J Fr Ophtalmol VL - 30 IS - 8 N2 - INTRODUCTION: Fortified antibiotic ophthalmic solutions are regularly administered as an immediate treatment for bacterial keratitis. Fortified antibiotics used to be self-prepared by nurses. To solve this problem, pharmacy staff studied the stability of three 5% solutions of vancomycin, amikacin, and ceftazidime prepared in aseptic conditions from parenteral antibiotic solutions. MATERIAL AND METHODS: Solutions were frozen at -20 degrees C. Each solution were examined before storage and over a 75-day period. Ceftazidime and amikacin were diluted in 0.9% sodium chloride and vancomycin in 5% dextrose. Over a 75-day period, physical and pharmacological (absorbance spectra) properties and the sterility of each stock solution were studied. RESULTS: The pH of amikacin (6.51), ceftazidime (6.47), and vancomycin (3.77) remained stable during the 75-day period. Osmolarities also remained stable (367, 488, and 351 mOsm/L, respectively). There were no significant differences in the concentration, osmolarity, and pH of the three antibiotic solutions before storage and after 75 days of freezing. Over a 75-day period, the stability of amikacin, ceftazidime, and vancomycin remained constant; no contamination was detected before storage and after 75 days. CONCLUSION: Topical fortified antibiotic solutions can be stored for 75 days at -20 degrees C (15 days quarantine). After this time, these eye-drops should be stored at 4 degrees C and should be discarded after 3 days. SN - 1773-0597 UR - https://www.unboundmedicine.com/medline/citation/17978677/[Fortified_antibiotic__vancomycin_amikacin_and_ceftazidime__eye_drop_stability_assessment_at__20_degrees_C]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0181-5512(07)92614-5 DB - PRIME DP - Unbound Medicine ER -