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Electrochemical behavior and antioxidant and prooxidant activity of natural phenolics.
Molecules. 2007 Oct 24; 12(10):2327-40.M

Abstract

We have investigated the electrochemical oxidation of a number natural phenolics (salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, protocatechuic acid, o-coumaric acid, m-coumaric acid, p-coumaric acid, caffeic acid, quercetin and rutin) using cyclic voltammetry. The antioxidant properties of these compounds were also studied. A structural analysis of the tested phenolics suggests that multiple OH substitution and conjugation are important determinants of the free radical scavenging activity and electrochemical behavior. Compounds with low oxidation potentials (Epa lower than 0.45) showed antioxidant activity, whereas compounds with high Epa values (>0.45) act as prooxidants.

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Authors+Show Affiliations

Simić A
Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia. simic@chem.bg.ac.yu
Manojlović D
No affiliation info available
Segan D
No affiliation info available
Todorović M
No affiliation info available

MeSH

AntioxidantsCaffeic AcidsCoumaric AcidsElectrochemistryFree Radical ScavengersHydroxybenzoatesMolecular StructurePhenolsQuercetinReactive Oxygen SpeciesRutinSalicylic Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17978760

Citation

Simić, Aleksandra, et al. "Electrochemical Behavior and Antioxidant and Prooxidant Activity of Natural Phenolics." Molecules (Basel, Switzerland), vol. 12, no. 10, 2007, pp. 2327-40.
Simić A, Manojlović D, Segan D, et al. Electrochemical behavior and antioxidant and prooxidant activity of natural phenolics. Molecules. 2007;12(10):2327-40.
Simić, A., Manojlović, D., Segan, D., & Todorović, M. (2007). Electrochemical behavior and antioxidant and prooxidant activity of natural phenolics. Molecules (Basel, Switzerland), 12(10), 2327-40.
Simić A, et al. Electrochemical Behavior and Antioxidant and Prooxidant Activity of Natural Phenolics. Molecules. 2007 Oct 24;12(10):2327-40. PubMed PMID: 17978760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical behavior and antioxidant and prooxidant activity of natural phenolics. AU - Simić,Aleksandra, AU - Manojlović,Dragan, AU - Segan,Dejan, AU - Todorović,Marija, Y1 - 2007/10/24/ PY - 2007/06/15/received PY - 2007/10/04/revised PY - 2007/10/04/accepted PY - 2007/11/6/pubmed PY - 2007/12/19/medline PY - 2007/11/6/entrez SP - 2327 EP - 40 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 12 IS - 10 N2 - We have investigated the electrochemical oxidation of a number natural phenolics (salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, protocatechuic acid, o-coumaric acid, m-coumaric acid, p-coumaric acid, caffeic acid, quercetin and rutin) using cyclic voltammetry. The antioxidant properties of these compounds were also studied. A structural analysis of the tested phenolics suggests that multiple OH substitution and conjugation are important determinants of the free radical scavenging activity and electrochemical behavior. Compounds with low oxidation potentials (Epa lower than 0.45) showed antioxidant activity, whereas compounds with high Epa values (>0.45) act as prooxidants. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/17978760/Electrochemical_behavior_and_antioxidant_and_prooxidant_activity_of_natural_phenolics_ L2 - https://www.mdpi.com/resolver?pii=12102327 DB - PRIME DP - Unbound Medicine ER -