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Investigation of electrochemical behavior of lipid lowering agent atorvastatin calcium in aqueous media and its determination from pharmaceutical dosage forms and biological fluids using boron-doped diamond and glassy carbon electrodes.
Comb Chem High Throughput Screen. 2007 Aug; 10(7):571-82.CC

Abstract

The electrochemical behavior of atorvastatin calcium at glassy carbon and boron-doped diamond electrodes has been studied using voltammetric techniques. The possible mechanism of oxidation was discussed with model compounds. The dependence of the peak current and potentials on pH, concentration, scan rate and nature of the buffer were investigated for both electrodes. The oxidation of atorvastatin was irreversible and exhibited a diffusion-controlled fashion on the diamond electrode. A linear response was obtained within the range of 9.65 x 10(-7) - 3.86 x 10(-5) M in 0.1 M H(2)SO(4) solution for both electrodes. The detection limits of a standard solution are estimated to be 2.11 x 10(-7) M with differential pulse voltammetry (DPV) and 2.05 x 10(-7)M with square wave voltammetry (SWV) for glassy carbon electrode, and 2.27 x 10(-7) M with DPV and 1.31 x 10(-7)M with SWV for diamond electrodes in 0.1 M H(2)SO(4) solution. The repeatability of the methods was found good for both electrodes. The methods were fully validated and successfully applied to the high-throughput determination of the drug in tablets, human serum and human urine with good recoveries.

Authors+Show Affiliations

Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17979640

Citation

Dogan-Topal, Burcu, et al. "Investigation of Electrochemical Behavior of Lipid Lowering Agent Atorvastatin Calcium in Aqueous Media and Its Determination From Pharmaceutical Dosage Forms and Biological Fluids Using Boron-doped Diamond and Glassy Carbon Electrodes." Combinatorial Chemistry & High Throughput Screening, vol. 10, no. 7, 2007, pp. 571-82.
Dogan-Topal B, Uslu B, Ozkan SA. Investigation of electrochemical behavior of lipid lowering agent atorvastatin calcium in aqueous media and its determination from pharmaceutical dosage forms and biological fluids using boron-doped diamond and glassy carbon electrodes. Comb Chem High Throughput Screen. 2007;10(7):571-82.
Dogan-Topal, B., Uslu, B., & Ozkan, S. A. (2007). Investigation of electrochemical behavior of lipid lowering agent atorvastatin calcium in aqueous media and its determination from pharmaceutical dosage forms and biological fluids using boron-doped diamond and glassy carbon electrodes. Combinatorial Chemistry & High Throughput Screening, 10(7), 571-82.
Dogan-Topal B, Uslu B, Ozkan SA. Investigation of Electrochemical Behavior of Lipid Lowering Agent Atorvastatin Calcium in Aqueous Media and Its Determination From Pharmaceutical Dosage Forms and Biological Fluids Using Boron-doped Diamond and Glassy Carbon Electrodes. Comb Chem High Throughput Screen. 2007;10(7):571-82. PubMed PMID: 17979640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of electrochemical behavior of lipid lowering agent atorvastatin calcium in aqueous media and its determination from pharmaceutical dosage forms and biological fluids using boron-doped diamond and glassy carbon electrodes. AU - Dogan-Topal,Burcu, AU - Uslu,Bengi, AU - Ozkan,Sibel A, PY - 2007/11/6/pubmed PY - 2008/2/27/medline PY - 2007/11/6/entrez SP - 571 EP - 82 JF - Combinatorial chemistry & high throughput screening JO - Comb Chem High Throughput Screen VL - 10 IS - 7 N2 - The electrochemical behavior of atorvastatin calcium at glassy carbon and boron-doped diamond electrodes has been studied using voltammetric techniques. The possible mechanism of oxidation was discussed with model compounds. The dependence of the peak current and potentials on pH, concentration, scan rate and nature of the buffer were investigated for both electrodes. The oxidation of atorvastatin was irreversible and exhibited a diffusion-controlled fashion on the diamond electrode. A linear response was obtained within the range of 9.65 x 10(-7) - 3.86 x 10(-5) M in 0.1 M H(2)SO(4) solution for both electrodes. The detection limits of a standard solution are estimated to be 2.11 x 10(-7) M with differential pulse voltammetry (DPV) and 2.05 x 10(-7)M with square wave voltammetry (SWV) for glassy carbon electrode, and 2.27 x 10(-7) M with DPV and 1.31 x 10(-7)M with SWV for diamond electrodes in 0.1 M H(2)SO(4) solution. The repeatability of the methods was found good for both electrodes. The methods were fully validated and successfully applied to the high-throughput determination of the drug in tablets, human serum and human urine with good recoveries. SN - 1386-2073 UR - https://www.unboundmedicine.com/medline/citation/17979640/Investigation_of_electrochemical_behavior_of_lipid_lowering_agent_atorvastatin_calcium_in_aqueous_media_and_its_determination_from_pharmaceutical_dosage_forms_and_biological_fluids_using_boron_doped_diamond_and_glassy_carbon_electrodes_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1386-2073&volume=10&issue=7&spage=571&aulast=Dogan-Topal DB - PRIME DP - Unbound Medicine ER -