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Insulin resistance and body composition in preterm born children during prepubertal ages.
Clin Endocrinol (Oxf). 2008 May; 68(5):773-9.CE

Abstract

BACKGROUND

Premature born children may show insulin resistance in childhood which may be due to intrauterine or postnatal adverse environmental factors.

OBJECTIVE

Aim of this study was to evaluate insulin resistance and body composition in preterm born children born appropriate for gestational age (AGA) or small for gestational age (SGA) and relations with IGF-I, IGFBP-3 axis.

METHODS

Ninety-three preterm born children grouped as premature SGA (n = 30) and premature AGA (n = 63) were evaluated at age 4.6 +/- 0.2 years and 4.7 +/- 0.1 years with respect to their glucose, insulin, IGF-I, IGFBP-3, IGFBP-1, leptin levels and body composition by dual-energy X-ray absorptiometry. Their data were compared to that of body mass index (BMI) matched term SGA (n = 42) and term AGA (n = 44) children of age 4.5 +/- 0.2 and 3.8 +/- 0.1 years. All children had height appropriate for their target height. Insulin resistance was evaluated by basal insulin and homeostasis model assessment for insulin resistance (HOMA-IR).

RESULTS

Basal insulin level was similar in preterm AGA (4.3 +/- 1.4 pmol/l) and term AGA (7.9 +/- 6.4 pmol/l) children at similar and normal BMI levels. Preterm SGA children had insulin levels (5.0 +/- 3.6 pmol/l) similar to preterm AGA children but significantly lower than that in term SGA children (23.7 +/- 20.8 pmol/l) (P = 0.001). Similar results were obtained for HOMA-IR. Term SGA children had also significantly lower IGFBP-1 levels. Body composition, leptin and IGFBP-3 did not differ between the respective groups. IGF-I was lower in preterm AGA (5.0 +/- 0.6 nmol/l) than in term AGA (8.3 +/- 1.2 nmol/l) (P < 0.001) children.

CONCLUSIONS

Premature born AGA and SGA children do not have insulin resistance when compared to term children if they have made a catch-up growth appropriate for their target height and have normal BMI. The similar insulin levels in preterm SGA and preterm AGA children together with increased insulin levels in term SGA children points to the fact that it is the intrauterine restriction in the third trimester that has an adverse effect on future adverse metabolic outcome.

Authors+Show Affiliations

Pediatric Endocrinology Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. feyzad@istanbul.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17980003

Citation

Darendeliler, Feyza, et al. "Insulin Resistance and Body Composition in Preterm Born Children During Prepubertal Ages." Clinical Endocrinology, vol. 68, no. 5, 2008, pp. 773-9.
Darendeliler F, Bas F, Bundak R, et al. Insulin resistance and body composition in preterm born children during prepubertal ages. Clin Endocrinol (Oxf). 2008;68(5):773-9.
Darendeliler, F., Bas, F., Bundak, R., Coban, A., Sancakli, O., Eryilmaz, S. K., Kucukemre, B., Disci, R., Gokcay, G., Aki, S., Ince, Z., & Eskiyurt, N. (2008). Insulin resistance and body composition in preterm born children during prepubertal ages. Clinical Endocrinology, 68(5), 773-9.
Darendeliler F, et al. Insulin Resistance and Body Composition in Preterm Born Children During Prepubertal Ages. Clin Endocrinol (Oxf). 2008;68(5):773-9. PubMed PMID: 17980003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance and body composition in preterm born children during prepubertal ages. AU - Darendeliler,Feyza, AU - Bas,Firdevs, AU - Bundak,Ruveyde, AU - Coban,Asuman, AU - Sancakli,Ozlem, AU - Eryilmaz,Sema Kabatas, AU - Kucukemre,Banu, AU - Disci,Rian, AU - Gokcay,Gulbin, AU - Aki,Semih, AU - Ince,Zeynep, AU - Eskiyurt,Nurten, Y1 - 2007/11/02/ PY - 2007/11/6/pubmed PY - 2009/9/16/medline PY - 2007/11/6/entrez SP - 773 EP - 9 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 68 IS - 5 N2 - BACKGROUND: Premature born children may show insulin resistance in childhood which may be due to intrauterine or postnatal adverse environmental factors. OBJECTIVE: Aim of this study was to evaluate insulin resistance and body composition in preterm born children born appropriate for gestational age (AGA) or small for gestational age (SGA) and relations with IGF-I, IGFBP-3 axis. METHODS: Ninety-three preterm born children grouped as premature SGA (n = 30) and premature AGA (n = 63) were evaluated at age 4.6 +/- 0.2 years and 4.7 +/- 0.1 years with respect to their glucose, insulin, IGF-I, IGFBP-3, IGFBP-1, leptin levels and body composition by dual-energy X-ray absorptiometry. Their data were compared to that of body mass index (BMI) matched term SGA (n = 42) and term AGA (n = 44) children of age 4.5 +/- 0.2 and 3.8 +/- 0.1 years. All children had height appropriate for their target height. Insulin resistance was evaluated by basal insulin and homeostasis model assessment for insulin resistance (HOMA-IR). RESULTS: Basal insulin level was similar in preterm AGA (4.3 +/- 1.4 pmol/l) and term AGA (7.9 +/- 6.4 pmol/l) children at similar and normal BMI levels. Preterm SGA children had insulin levels (5.0 +/- 3.6 pmol/l) similar to preterm AGA children but significantly lower than that in term SGA children (23.7 +/- 20.8 pmol/l) (P = 0.001). Similar results were obtained for HOMA-IR. Term SGA children had also significantly lower IGFBP-1 levels. Body composition, leptin and IGFBP-3 did not differ between the respective groups. IGF-I was lower in preterm AGA (5.0 +/- 0.6 nmol/l) than in term AGA (8.3 +/- 1.2 nmol/l) (P < 0.001) children. CONCLUSIONS: Premature born AGA and SGA children do not have insulin resistance when compared to term children if they have made a catch-up growth appropriate for their target height and have normal BMI. The similar insulin levels in preterm SGA and preterm AGA children together with increased insulin levels in term SGA children points to the fact that it is the intrauterine restriction in the third trimester that has an adverse effect on future adverse metabolic outcome. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/17980003/Insulin_resistance_and_body_composition_in_preterm_born_children_during_prepubertal_ages_ DB - PRIME DP - Unbound Medicine ER -