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A systematic review of commonly used medical treatments for hirsutism in women.
Clin Endocrinol (Oxf). 2008 May; 68(5):800-5.CE

Abstract

OBJECTIVE

To evaluate the efficacy of various drug treatments in common use for hirsutism in women.

DESIGN

A systematic review of published randomized controlled trials (RCTs). We included RCTs that tested commonly prescribed pharmaceutical treatments for hirsutism and the most common outcome measure, a decrease in Ferriman-Gallwey (F-G) score for hirsutism after 6 months of treatment. We excluded trials using unconventional treatments, alternative treatment outcomes, and trials referring to women with conditions other than polycystic ovary syndrome or idiopathic hirsutism.

RESULTS

We identified 79 RCTs of which 28 were eligible for analysis. A significant reduction in hirsutism was found for flutamide, spironolactone, cyproterone acetate combined with an oral contraceptive, thiazolidinediones, oral contraceptive pills (OCPs), finasteride and metformin but not for placebo. Reduction in F-G score in response to treatment was negatively associated with body mass index (BMI) (r = -0.38; P = 0.004).

CONCLUSIONS

Seven different drug groups result in improvement in hirsutism and creative use of these will open new options for women with hirsutism. Obesity has a negative impact on the efficacy of treatments for hirsutism, thus appropriate lifestyle advice is necessary for a successful treatment programme.

Authors+Show Affiliations

Department of Endocrinology, University College London Hospitals, London, UK.No affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

17980017

Citation

Koulouri, Olympia, and Gerard S. Conway. "A Systematic Review of Commonly Used Medical Treatments for Hirsutism in Women." Clinical Endocrinology, vol. 68, no. 5, 2008, pp. 800-5.
Koulouri O, Conway GS. A systematic review of commonly used medical treatments for hirsutism in women. Clin Endocrinol (Oxf). 2008;68(5):800-5.
Koulouri, O., & Conway, G. S. (2008). A systematic review of commonly used medical treatments for hirsutism in women. Clinical Endocrinology, 68(5), 800-5.
Koulouri O, Conway GS. A Systematic Review of Commonly Used Medical Treatments for Hirsutism in Women. Clin Endocrinol (Oxf). 2008;68(5):800-5. PubMed PMID: 17980017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review of commonly used medical treatments for hirsutism in women. AU - Koulouri,Olympia, AU - Conway,Gerard S, Y1 - 2007/11/02/ PY - 2007/11/6/pubmed PY - 2009/9/16/medline PY - 2007/11/6/entrez SP - 800 EP - 5 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 68 IS - 5 N2 - OBJECTIVE: To evaluate the efficacy of various drug treatments in common use for hirsutism in women. DESIGN: A systematic review of published randomized controlled trials (RCTs). We included RCTs that tested commonly prescribed pharmaceutical treatments for hirsutism and the most common outcome measure, a decrease in Ferriman-Gallwey (F-G) score for hirsutism after 6 months of treatment. We excluded trials using unconventional treatments, alternative treatment outcomes, and trials referring to women with conditions other than polycystic ovary syndrome or idiopathic hirsutism. RESULTS: We identified 79 RCTs of which 28 were eligible for analysis. A significant reduction in hirsutism was found for flutamide, spironolactone, cyproterone acetate combined with an oral contraceptive, thiazolidinediones, oral contraceptive pills (OCPs), finasteride and metformin but not for placebo. Reduction in F-G score in response to treatment was negatively associated with body mass index (BMI) (r = -0.38; P = 0.004). CONCLUSIONS: Seven different drug groups result in improvement in hirsutism and creative use of these will open new options for women with hirsutism. Obesity has a negative impact on the efficacy of treatments for hirsutism, thus appropriate lifestyle advice is necessary for a successful treatment programme. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/17980017/A_systematic_review_of_commonly_used_medical_treatments_for_hirsutism_in_women_ L2 - https://doi.org/10.1111/j.1365-2265.2007.03105.x DB - PRIME DP - Unbound Medicine ER -