Tags

Type your tag names separated by a space and hit enter

Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15; 32(2):462-6.PN

Abstract

Clinical genetic studies have implicated neuregulin-1 [NRG1] as a leading susceptibility gene for schizophrenia. NRG1 is known to play a significant role in the developing brain, which is consistent with the prevailing neurodevelopmental model of schizophrenia. Thus, the emotional and social phenotype of adult mice with heterozygous 'knockout' of transmembrane [TM]-domain NRG1 was examined further in both sexes. Emotional/anxiety-related behaviour was assessed using the elevated plus-maze and the light-dark test. Social behaviour was examined in terms of dyadic interactions between NRG1 mutants and an unfamiliar C57BL6 conspecific in a novel environment. There was no effect of NRG1 genotype on performance in either test of emotionality/anxiety. However, previous reports of hyperactivity in NRG1 mutants were confirmed in both paradigms. In the test of social interaction, aggressive following was increased in NRG1 mutants of both sexes, together with an increase in walkovers in female mutants. These findings elaborate the specificity of the NRG1 phenotype for the social rather than the emotional/anxiety-related domain. They indicate that NRG1 is involved in the regulation of reciprocal social interaction behaviour and thus suggest a putative role for NRG1 in a schizophrenia-related endophenotype.

Authors+Show Affiliations

Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland. cotuathaigh@rcsi.ieNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17980471

Citation

O'Tuathaigh, Colm M P., et al. "Disruption to Social Dyadic Interactions but Not Emotional/anxiety-related Behaviour in Mice With Heterozygous 'knockout' of the Schizophrenia Risk Gene Neuregulin-1." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 2, 2008, pp. 462-6.
O'Tuathaigh CM, O'Connor AM, O'Sullivan GJ, et al. Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(2):462-6.
O'Tuathaigh, C. M., O'Connor, A. M., O'Sullivan, G. J., Lai, D., Harvey, R., Croke, D. T., & Waddington, J. L. (2008). Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(2), 462-6.
O'Tuathaigh CM, et al. Disruption to Social Dyadic Interactions but Not Emotional/anxiety-related Behaviour in Mice With Heterozygous 'knockout' of the Schizophrenia Risk Gene Neuregulin-1. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):462-6. PubMed PMID: 17980471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. AU - O'Tuathaigh,Colm M P, AU - O'Connor,Anne-Marie, AU - O'Sullivan,Gerard J, AU - Lai,Donna, AU - Harvey,Richard, AU - Croke,David T, AU - Waddington,John L, Y1 - 2007/09/29/ PY - 2007/06/12/received PY - 2007/09/24/revised PY - 2007/09/24/accepted PY - 2007/11/6/pubmed PY - 2008/5/31/medline PY - 2007/11/6/entrez SP - 462 EP - 6 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 32 IS - 2 N2 - Clinical genetic studies have implicated neuregulin-1 [NRG1] as a leading susceptibility gene for schizophrenia. NRG1 is known to play a significant role in the developing brain, which is consistent with the prevailing neurodevelopmental model of schizophrenia. Thus, the emotional and social phenotype of adult mice with heterozygous 'knockout' of transmembrane [TM]-domain NRG1 was examined further in both sexes. Emotional/anxiety-related behaviour was assessed using the elevated plus-maze and the light-dark test. Social behaviour was examined in terms of dyadic interactions between NRG1 mutants and an unfamiliar C57BL6 conspecific in a novel environment. There was no effect of NRG1 genotype on performance in either test of emotionality/anxiety. However, previous reports of hyperactivity in NRG1 mutants were confirmed in both paradigms. In the test of social interaction, aggressive following was increased in NRG1 mutants of both sexes, together with an increase in walkovers in female mutants. These findings elaborate the specificity of the NRG1 phenotype for the social rather than the emotional/anxiety-related domain. They indicate that NRG1 is involved in the regulation of reciprocal social interaction behaviour and thus suggest a putative role for NRG1 in a schizophrenia-related endophenotype. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17980471/Disruption_to_social_dyadic_interactions_but_not_emotional/anxiety_related_behaviour_in_mice_with_heterozygous_'knockout'_of_the_schizophrenia_risk_gene_neuregulin_1_ DB - PRIME DP - Unbound Medicine ER -