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Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats.
J Ethnopharmacol. 2008 Jan 17; 115(2):323-6.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Traditionally fruits of Ficus glomerata Roxb (Family: Moraceae) are used to treat anemia and gastrointestinal disorders.

AIM

Gastroprotective effect of 50% ethanolic extract of F. glomerata fruit (FGE) was studied in different gastric ulcer models in rats.

METHODS

FGE (50, 100 and 200 mg/kg body weight) was administered orally, twice daily for 5 days for prevention from pylorus ligation (PL), ethanol (EtOH) and cold restraint stress (CRS)-induced ulcers. Estimation of H+K+ATPase activity and gastric wall mucous were performed in EtOH-induced ulcer and antioxidant enzyme activities in supernatant mitochondrial fraction of CRS-induced ulcers.

RESULTS

FGE showed dose dependent inhibition of ulcer index in pylorus ligation, ethanol and cold restraint stress-induced ulcers. FGE prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by significant decrease in superoxide dismutase, H+K+ATPase and increase in catalase activity. High performance thin layer chromatography (HPTLC) analysis showed the presence of 0.57% and 0.36% w/w of gallic acid and ellagic acid in FGE.

CONCLUSIONS

Our results show that F. glomerata possess significant gastroprotective activity which might be due to gastric defence factors and phenolics might be the main constituents responsible for this activity.

Authors+Show Affiliations

Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India. ethnopharmacology1@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17980529

Citation

Rao, Ch V., et al. "Gastroprotective Effect of Standardized Extract of Ficus Glomerata Fruit On Experimental Gastric Ulcers in Rats." Journal of Ethnopharmacology, vol. 115, no. 2, 2008, pp. 323-6.
Rao ChV, Verma AR, Vijayakumar M, et al. Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. J Ethnopharmacol. 2008;115(2):323-6.
Rao, C. h. V., Verma, A. R., Vijayakumar, M., & Rastogi, S. (2008). Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. Journal of Ethnopharmacology, 115(2), 323-6.
Rao ChV, et al. Gastroprotective Effect of Standardized Extract of Ficus Glomerata Fruit On Experimental Gastric Ulcers in Rats. J Ethnopharmacol. 2008 Jan 17;115(2):323-6. PubMed PMID: 17980529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. AU - Rao,Ch V, AU - Verma,Arti R, AU - Vijayakumar,M, AU - Rastogi,S, Y1 - 2007/09/29/ PY - 2007/01/08/received PY - 2007/06/22/revised PY - 2007/09/22/accepted PY - 2007/11/6/pubmed PY - 2008/4/23/medline PY - 2007/11/6/entrez SP - 323 EP - 6 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 115 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally fruits of Ficus glomerata Roxb (Family: Moraceae) are used to treat anemia and gastrointestinal disorders. AIM: Gastroprotective effect of 50% ethanolic extract of F. glomerata fruit (FGE) was studied in different gastric ulcer models in rats. METHODS: FGE (50, 100 and 200 mg/kg body weight) was administered orally, twice daily for 5 days for prevention from pylorus ligation (PL), ethanol (EtOH) and cold restraint stress (CRS)-induced ulcers. Estimation of H+K+ATPase activity and gastric wall mucous were performed in EtOH-induced ulcer and antioxidant enzyme activities in supernatant mitochondrial fraction of CRS-induced ulcers. RESULTS: FGE showed dose dependent inhibition of ulcer index in pylorus ligation, ethanol and cold restraint stress-induced ulcers. FGE prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by significant decrease in superoxide dismutase, H+K+ATPase and increase in catalase activity. High performance thin layer chromatography (HPTLC) analysis showed the presence of 0.57% and 0.36% w/w of gallic acid and ellagic acid in FGE. CONCLUSIONS: Our results show that F. glomerata possess significant gastroprotective activity which might be due to gastric defence factors and phenolics might be the main constituents responsible for this activity. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17980529/Gastroprotective_effect_of_standardized_extract_of_Ficus_glomerata_fruit_on_experimental_gastric_ulcers_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00498-9 DB - PRIME DP - Unbound Medicine ER -