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Effect of hydroalcoholic extracts of Nasturtium officinale leaves on lipid profile in high-fat diet rats.
J Ethnopharmacol. 2008 Jan 04; 115(1):116-21.JE

Abstract

AIM OF THE STUDY

Nasturtium officinale R. Br. (Brassicaceae) is used as a home remedy in Iran as a cardioprotective agent without any scientific background. In this investigation an attempt was made to study the effect of Nasturtium officinale hydroalcoholic extract (NOE) on serum lipid profile which is closely associated with many cardiovascular diseases.

MATERIALS AND METHODS

Accordingly, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were among the parameters investigated. We also evaluated the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as a measure of hepatic cell damages.

RESULTS

Intragastric administration of NOE (500 mg/kg body weight per day) to groups of hypercholesterolaemic rats for 10 days lowered their serum TC, TG and LDL-C by 34.2, 30.1, and 52.9%, respectively, while raised the serum HDL-C level by 27.0% after 10 days of treatments. Treatment with NOE reduced serum ALT and AST levels compared to high-fat diet groups.

CONCLUSIONS

Based on these data, it is concluded that the NOE has definite cardioprotective potential and these results constitute a valid scientific basis for consuming Nasturtium officinale for medicinal application.

Authors+Show Affiliations

Institute of Biochemistry and Biophysics, PO Box 13145-1384, University of Tehran, Tehran, Iran.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17980985

Citation

Bahramikia, Seifollah, and Razieh Yazdanparast. "Effect of Hydroalcoholic Extracts of Nasturtium Officinale Leaves On Lipid Profile in High-fat Diet Rats." Journal of Ethnopharmacology, vol. 115, no. 1, 2008, pp. 116-21.
Bahramikia S, Yazdanparast R. Effect of hydroalcoholic extracts of Nasturtium officinale leaves on lipid profile in high-fat diet rats. J Ethnopharmacol. 2008;115(1):116-21.
Bahramikia, S., & Yazdanparast, R. (2008). Effect of hydroalcoholic extracts of Nasturtium officinale leaves on lipid profile in high-fat diet rats. Journal of Ethnopharmacology, 115(1), 116-21.
Bahramikia S, Yazdanparast R. Effect of Hydroalcoholic Extracts of Nasturtium Officinale Leaves On Lipid Profile in High-fat Diet Rats. J Ethnopharmacol. 2008 Jan 4;115(1):116-21. PubMed PMID: 17980985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of hydroalcoholic extracts of Nasturtium officinale leaves on lipid profile in high-fat diet rats. AU - Bahramikia,Seifollah, AU - Yazdanparast,Razieh, Y1 - 2007/09/25/ PY - 2007/01/24/received PY - 2007/09/12/revised PY - 2007/09/18/accepted PY - 2007/11/6/pubmed PY - 2008/4/23/medline PY - 2007/11/6/entrez SP - 116 EP - 21 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 115 IS - 1 N2 - AIM OF THE STUDY: Nasturtium officinale R. Br. (Brassicaceae) is used as a home remedy in Iran as a cardioprotective agent without any scientific background. In this investigation an attempt was made to study the effect of Nasturtium officinale hydroalcoholic extract (NOE) on serum lipid profile which is closely associated with many cardiovascular diseases. MATERIALS AND METHODS: Accordingly, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were among the parameters investigated. We also evaluated the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as a measure of hepatic cell damages. RESULTS: Intragastric administration of NOE (500 mg/kg body weight per day) to groups of hypercholesterolaemic rats for 10 days lowered their serum TC, TG and LDL-C by 34.2, 30.1, and 52.9%, respectively, while raised the serum HDL-C level by 27.0% after 10 days of treatments. Treatment with NOE reduced serum ALT and AST levels compared to high-fat diet groups. CONCLUSIONS: Based on these data, it is concluded that the NOE has definite cardioprotective potential and these results constitute a valid scientific basis for consuming Nasturtium officinale for medicinal application. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17980985/Effect_of_hydroalcoholic_extracts_of_Nasturtium_officinale_leaves_on_lipid_profile_in_high_fat_diet_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00492-8 DB - PRIME DP - Unbound Medicine ER -