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Tolerability of omega-3 fatty acid supplements in perinatal women.
Prostaglandins Leukot Essent Fatty Acids. 2007 Oct-Nov; 77(3-4):203-8.PL

Abstract

BACKGROUND

Benefits of omega-3 fatty acids in perinatal women are well documented, although fish intake has declined among perinatal women.

OBJECTIVE

To determine the tolerability of omega-3 fatty acid supplementation in perinatal women.

DESIGN

Pregnant and postpartum women with major depressive disorder (MDD) entered an 8-week double-blind, placebo-controlled trial of omega-3 fatty acids. Four capsules provided 1.84 g/day of eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), or matching placebo (corn oil with 1% fish oil to maintain blind). Tolerability was assessed by clinician interview biweekly.

RESULTS

Fifty-nine women enrolled. Thirteen (22%) reported mainly transient side effects including dizziness, diarrhea, nausea, burping, heartburn/reflux, difficulty swallowing capsules, unpleasant breath/bad taste or feeling tired. The most common were unpleasant breath/bad taste and heartburn/reflux. Six reporting side effects received omega-3 fatty acids; seven received placebo. Neither pregnant nor postpartum women discontinued due to intolerability.

CONCLUSIONS

Omega-3 fatty acid supplements were well tolerated by perinatal women.

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Authors+Show Affiliations

Freeman MP
Women's Mental Health Center, Department of Psychiatry, Obstetrics and Gynecology, University of Texas--Southwestern Medical Center at Dallas, 6363 Forest Park, Suite 800, Dallas, TX 75235 9086, USA. marlene.freeman@utsouthwestern.edu
Sinha P
No affiliation info available

MeSH

Depressive Disorder, MajorDietary SupplementsDouble-Blind MethodFatty Acids, Omega-3FemaleFish OilsHumansPregnancyPregnancy ComplicationsPuerperal Disorders

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17981449

Citation

Freeman, Marlene P., and Priti Sinha. "Tolerability of Omega-3 Fatty Acid Supplements in Perinatal Women." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 77, no. 3-4, 2007, pp. 203-8.
Freeman MP, Sinha P. Tolerability of omega-3 fatty acid supplements in perinatal women. Prostaglandins Leukot Essent Fatty Acids. 2007;77(3-4):203-8.
Freeman, M. P., & Sinha, P. (2007). Tolerability of omega-3 fatty acid supplements in perinatal women. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 77(3-4), 203-8.
Freeman MP, Sinha P. Tolerability of Omega-3 Fatty Acid Supplements in Perinatal Women. Prostaglandins Leukot Essent Fatty Acids. 2007 Oct-Nov;77(3-4):203-8. PubMed PMID: 17981449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tolerability of omega-3 fatty acid supplements in perinatal women. AU - Freeman,Marlene P, AU - Sinha,Priti, Y1 - 2007/11/05/ PY - 2007/06/27/received PY - 2007/09/12/revised PY - 2007/09/15/accepted PY - 2007/11/6/pubmed PY - 2008/2/15/medline PY - 2007/11/6/entrez SP - 203 EP - 8 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 77 IS - 3-4 N2 - BACKGROUND: Benefits of omega-3 fatty acids in perinatal women are well documented, although fish intake has declined among perinatal women. OBJECTIVE: To determine the tolerability of omega-3 fatty acid supplementation in perinatal women. DESIGN: Pregnant and postpartum women with major depressive disorder (MDD) entered an 8-week double-blind, placebo-controlled trial of omega-3 fatty acids. Four capsules provided 1.84 g/day of eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), or matching placebo (corn oil with 1% fish oil to maintain blind). Tolerability was assessed by clinician interview biweekly. RESULTS: Fifty-nine women enrolled. Thirteen (22%) reported mainly transient side effects including dizziness, diarrhea, nausea, burping, heartburn/reflux, difficulty swallowing capsules, unpleasant breath/bad taste or feeling tired. The most common were unpleasant breath/bad taste and heartburn/reflux. Six reporting side effects received omega-3 fatty acids; seven received placebo. Neither pregnant nor postpartum women discontinued due to intolerability. CONCLUSIONS: Omega-3 fatty acid supplements were well tolerated by perinatal women. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/17981449/Tolerability_of_omega_3_fatty_acid_supplements_in_perinatal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(07)00130-5 DB - PRIME DP - Unbound Medicine ER -