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FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection.
J Leukoc Biol. 2008 Feb; 83(2):254-62.JL

Abstract

During the course of HIV-1 infection, the status of immune activation has been determined to be a powerful indicator of disease progression. The immune system has adopted self-regulatory mechanisms to counterbalance undesirable immune responses. CD25+CD4+ T regulatory (Treg) cells that express the transcription regulator, forkhead box P3 (FOXP3), play an important role in this immunosuppression. Using a combination of Treg cell discriminatory markers (FOXP3, CD25, CD127), we predicted that an expansion of Treg cell subsets would negatively correlate with immune activation during the early stages of HIV-1 infection. We report that FOXP3+CD127lo expressing CD4+ T cells increases in primary HIV-1 infection over time. Furthermore, the FOXP3+CD127lo CD4+ T cells may, in fact, reduce the levels of T cell activation following primary infection. It is interesting that the positive correlation between FOXP3+CD127lo CD4+ and CD25+CD127lo CD4+ T cells noted in HIV-uninfected persons is not only lost but may also be reversed in early, chronic HIV-1 infection. Unlike FOXP3+CD127lo CD4+, the level of FOXP3+CD25+CD127lo CD4+ T cells did not correlate with T cell activation, suggesting that these cells were not effective in reducing T cell activation. These observations suggest that different Treg populations may have different effects on reducing immune activation in HIV-1 infection and that the FOXP3+CD127lo CD4+ T cell population may be particularly important in limiting immune activation.

Authors+Show Affiliations

Division of Experimental Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA. lishomwa.ndhlovu@ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17982112

Citation

Ndhlovu, Lishomwa C., et al. "FOXP3 Expressing CD127lo CD4+ T Cells Inversely Correlate With CD38+ CD8+ T Cell Activation Levels in Primary HIV-1 Infection." Journal of Leukocyte Biology, vol. 83, no. 2, 2008, pp. 254-62.
Ndhlovu LC, Loo CP, Spotts G, et al. FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. J Leukoc Biol. 2008;83(2):254-62.
Ndhlovu, L. C., Loo, C. P., Spotts, G., Nixon, D. F., & Hecht, F. M. (2008). FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. Journal of Leukocyte Biology, 83(2), 254-62.
Ndhlovu LC, et al. FOXP3 Expressing CD127lo CD4+ T Cells Inversely Correlate With CD38+ CD8+ T Cell Activation Levels in Primary HIV-1 Infection. J Leukoc Biol. 2008;83(2):254-62. PubMed PMID: 17982112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. AU - Ndhlovu,Lishomwa C, AU - Loo,Christopher P, AU - Spotts,Gerald, AU - Nixon,Douglas F, AU - Hecht,Frederick M, Y1 - 2007/11/02/ PY - 2007/11/6/pubmed PY - 2008/4/10/medline PY - 2007/11/6/entrez SP - 254 EP - 62 JF - Journal of leukocyte biology JO - J Leukoc Biol VL - 83 IS - 2 N2 - During the course of HIV-1 infection, the status of immune activation has been determined to be a powerful indicator of disease progression. The immune system has adopted self-regulatory mechanisms to counterbalance undesirable immune responses. CD25+CD4+ T regulatory (Treg) cells that express the transcription regulator, forkhead box P3 (FOXP3), play an important role in this immunosuppression. Using a combination of Treg cell discriminatory markers (FOXP3, CD25, CD127), we predicted that an expansion of Treg cell subsets would negatively correlate with immune activation during the early stages of HIV-1 infection. We report that FOXP3+CD127lo expressing CD4+ T cells increases in primary HIV-1 infection over time. Furthermore, the FOXP3+CD127lo CD4+ T cells may, in fact, reduce the levels of T cell activation following primary infection. It is interesting that the positive correlation between FOXP3+CD127lo CD4+ and CD25+CD127lo CD4+ T cells noted in HIV-uninfected persons is not only lost but may also be reversed in early, chronic HIV-1 infection. Unlike FOXP3+CD127lo CD4+, the level of FOXP3+CD25+CD127lo CD4+ T cells did not correlate with T cell activation, suggesting that these cells were not effective in reducing T cell activation. These observations suggest that different Treg populations may have different effects on reducing immune activation in HIV-1 infection and that the FOXP3+CD127lo CD4+ T cell population may be particularly important in limiting immune activation. SN - 0741-5400 UR - https://www.unboundmedicine.com/medline/citation/17982112/FOXP3_expressing_CD127lo_CD4+_T_cells_inversely_correlate_with_CD38+_CD8+_T_cell_activation_levels_in_primary_HIV_1_infection_ L2 - https://doi.org/10.1189/jlb.0507281 DB - PRIME DP - Unbound Medicine ER -