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Metabolic changes in pregnancy.
Clin Obstet Gynecol. 2007 Dec; 50(4):938-48.CO

Abstract

Maternal metabolism changes substantially during pregnancy. Early gestation can be viewed as an anabolic state in the mother with an increase in maternal fat stores and small increases in insulin sensitivity. Hence, nutrients are stored in early pregnancy to meet the feto-placental and maternal demands of late gestation and lactation. In contrast, late pregnancy is better characterized as a catabolic state with decreased insulin sensitivity (increased insulin resistance). An increase in insulin resistance results in increases in maternal glucose and free fatty acid concentrations, allowing for greater substrate availability for fetal growth.

Authors+Show Affiliations

Departments of Obstetrics and Gynecology and Internal Medicine, University of Kentucky, Lexington, Kentucky 40536-0293, USA. kylain2@email.uky.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17982337

Citation

Lain, Kristine Y., and Patrick M. Catalano. "Metabolic Changes in Pregnancy." Clinical Obstetrics and Gynecology, vol. 50, no. 4, 2007, pp. 938-48.
Lain KY, Catalano PM. Metabolic changes in pregnancy. Clin Obstet Gynecol. 2007;50(4):938-48.
Lain, K. Y., & Catalano, P. M. (2007). Metabolic changes in pregnancy. Clinical Obstetrics and Gynecology, 50(4), 938-48.
Lain KY, Catalano PM. Metabolic Changes in Pregnancy. Clin Obstet Gynecol. 2007;50(4):938-48. PubMed PMID: 17982337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic changes in pregnancy. AU - Lain,Kristine Y, AU - Catalano,Patrick M, PY - 2007/11/6/pubmed PY - 2008/2/9/medline PY - 2007/11/6/entrez SP - 938 EP - 48 JF - Clinical obstetrics and gynecology JO - Clin Obstet Gynecol VL - 50 IS - 4 N2 - Maternal metabolism changes substantially during pregnancy. Early gestation can be viewed as an anabolic state in the mother with an increase in maternal fat stores and small increases in insulin sensitivity. Hence, nutrients are stored in early pregnancy to meet the feto-placental and maternal demands of late gestation and lactation. In contrast, late pregnancy is better characterized as a catabolic state with decreased insulin sensitivity (increased insulin resistance). An increase in insulin resistance results in increases in maternal glucose and free fatty acid concentrations, allowing for greater substrate availability for fetal growth. SN - 1532-5520 UR - https://www.unboundmedicine.com/medline/citation/17982337/Metabolic_changes_in_pregnancy_ L2 - https://dx.doi.org/10.1097/GRF.0b013e31815a5494 DB - PRIME DP - Unbound Medicine ER -