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Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia.
Acta Trop. 2008 Jan; 105(1):39-44.AT

Abstract

OBJECTIVE

To describe clinical profile of patients with dengue virus infection hospitalized at a single center during the first outbreak of dengue in Makkah, Saudi Arabia from April to July 2004.

METHODS

Clinical information and laboratory abnormalities of patients with suspected dengue infection were collected by a standardized data collection sheet and review of medical records. Dengue virus infection was confirmed by a positive IgM capture ELISA or RT-PCR.

RESULTS

Of the 160 clinically suspected patients, 91 were confirmed (64 by IgM ELISA, 14 by RT-PCR and 13 by both) to have dengue virus infection. Dengue serotypes 2 and 3 were identified in 19 and 4 patients respectively. Most patients were young adults with median age of 26 (range=6-94) years and male:female ratio of 1.5:1. The common symptoms were fever (100%), malaise (83%), musculoskeletal pain (81%), headache (75%), nausea (69%), vomiting (65%) and abdominal pain (48%). According to World Health Organization (WHO) classification (10 patients were excluded due to lack of serial hematocrits), 75 (93%) had dengue fever (DF) and 6 (7%) had dengue hemorrhagic fever (DHF). Only one patient with DHF was in pediatric age group. Twenty-one patients (5 with DHF and 16 with DF) developed one or more clinical complications that included bleeding (14), shock (4), seizures (3), acute renal failure (2), meningo-encephalitis (1), and secondary bacterial infection (1). Only one patient with shock had dengue shock syndrome (DSS) by WHO classification. Development of clinical complications was significantly associated with absence of musculoskeletal pain (p-value=0.03), lower platelet counts (p-value=0.03) and higher serum aspartate aminotransferase levels (p-value=0.04). The median duration of symptoms and hospitalization was 8 days (range=3-18) and 4 days (range=1-10) respectively. No mortality was noted.

CONCLUSION

Occurrence of dengue virus infection in Makkah, Saudi Arabia is documented. Continued surveillance and effective vector control programs are warranted due to unique population dynamics of Makkah that receives millions of pilgrims annually from all over the world.

Authors+Show Affiliations

Division of Rheumatology, University of Arkansas for Medical Sciences, Mail Slot - 509, 4301 West Markham, Little Rock, AR 72205, USA. nakhan99@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17983609

Citation

Khan, Nasim A., et al. "Clinical Profile and Outcome of Hospitalized Patients During First Outbreak of Dengue in Makkah, Saudi Arabia." Acta Tropica, vol. 105, no. 1, 2008, pp. 39-44.
Khan NA, Azhar EI, El-Fiky S, et al. Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. Acta Trop. 2008;105(1):39-44.
Khan, N. A., Azhar, E. I., El-Fiky, S., Madani, H. H., Abuljadial, M. A., Ashshi, A. M., Turkistani, A. M., & Hamouh, E. A. (2008). Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. Acta Tropica, 105(1), 39-44.
Khan NA, et al. Clinical Profile and Outcome of Hospitalized Patients During First Outbreak of Dengue in Makkah, Saudi Arabia. Acta Trop. 2008;105(1):39-44. PubMed PMID: 17983609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. AU - Khan,Nasim A, AU - Azhar,Esam I, AU - El-Fiky,Suzan, AU - Madani,Hosam H, AU - Abuljadial,Maha A, AU - Ashshi,Ahmad M, AU - Turkistani,Abdulhafis M, AU - Hamouh,Esam A, Y1 - 2007/09/29/ PY - 2007/03/22/received PY - 2007/07/16/revised PY - 2007/09/26/accepted PY - 2007/11/7/pubmed PY - 2008/3/12/medline PY - 2007/11/7/entrez SP - 39 EP - 44 JF - Acta tropica JO - Acta Trop VL - 105 IS - 1 N2 - OBJECTIVE: To describe clinical profile of patients with dengue virus infection hospitalized at a single center during the first outbreak of dengue in Makkah, Saudi Arabia from April to July 2004. METHODS: Clinical information and laboratory abnormalities of patients with suspected dengue infection were collected by a standardized data collection sheet and review of medical records. Dengue virus infection was confirmed by a positive IgM capture ELISA or RT-PCR. RESULTS: Of the 160 clinically suspected patients, 91 were confirmed (64 by IgM ELISA, 14 by RT-PCR and 13 by both) to have dengue virus infection. Dengue serotypes 2 and 3 were identified in 19 and 4 patients respectively. Most patients were young adults with median age of 26 (range=6-94) years and male:female ratio of 1.5:1. The common symptoms were fever (100%), malaise (83%), musculoskeletal pain (81%), headache (75%), nausea (69%), vomiting (65%) and abdominal pain (48%). According to World Health Organization (WHO) classification (10 patients were excluded due to lack of serial hematocrits), 75 (93%) had dengue fever (DF) and 6 (7%) had dengue hemorrhagic fever (DHF). Only one patient with DHF was in pediatric age group. Twenty-one patients (5 with DHF and 16 with DF) developed one or more clinical complications that included bleeding (14), shock (4), seizures (3), acute renal failure (2), meningo-encephalitis (1), and secondary bacterial infection (1). Only one patient with shock had dengue shock syndrome (DSS) by WHO classification. Development of clinical complications was significantly associated with absence of musculoskeletal pain (p-value=0.03), lower platelet counts (p-value=0.03) and higher serum aspartate aminotransferase levels (p-value=0.04). The median duration of symptoms and hospitalization was 8 days (range=3-18) and 4 days (range=1-10) respectively. No mortality was noted. CONCLUSION: Occurrence of dengue virus infection in Makkah, Saudi Arabia is documented. Continued surveillance and effective vector control programs are warranted due to unique population dynamics of Makkah that receives millions of pilgrims annually from all over the world. SN - 0001-706X UR - https://www.unboundmedicine.com/medline/citation/17983609/Clinical_profile_and_outcome_of_hospitalized_patients_during_first_outbreak_of_dengue_in_Makkah_Saudi_Arabia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(07)00228-8 DB - PRIME DP - Unbound Medicine ER -