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Susceptibility of wood ducks to H5N1 highly pathogenic avian influenza virus.
J Wildl Dis. 2007 Oct; 43(4):660-7.JW

Abstract

Since 2002, H5N1 highly pathogenic avian influenza (HPAI) viruses have caused mortality in numerous species of wild birds; this is atypical for avian influenza virus (AIV) infections in these avian species, especially for species within the order Anseriformes. Although these infections document the susceptibility of wild birds to H5N1 HPAI viruses and the spillover of these viruses from infected domestic birds to wild birds, it is unknown whether H5N1 HPAI viruses can persist in free-living avian populations. In a previous study, we established that wood ducks (Aix sponsa) are highly susceptible to infection with H5N1 HPAI viruses. To quantify this susceptibility and further evaluate the likelihood of H5N1 HPAI viral maintenance in a wild bird population, we determined the concentration of virus required to produce infection in wood ducks. To accomplish this, 25 wood ducks were inoculated intranasally at 12-16 wk of age with decreasing concentrations of a H5N1 HPAI virus (A/Whooper Swan/Mongolia/244/05 [H5N1]). The median infectious dose and the lethal dose of H5N1 HPAI virus in wood ducks were very low (10(0.95) and 10(1.71) median embryo infectious dose [EID(50)]/ml, respectively) and less than that of chickens (10(2.80) and 10(2.80) EID(50)/ml). These results confirm that wood ducks are highly susceptible to infection with H5N1 HPAI virus. The data from this study, combined with what is known experimentally about H5N1 HPAI virus infection in wood ducks and viral persistence in aquatic environments, suggest that the wood duck would represent a sensitive indicator species for H5N1 HPAI. Results also suggest that the potential for decreased transmission efficiency associated with reduced viral shedding (especially from the cloaca) and a loss of environmental fitness (in water), may be offset by the ability of this virus to be transmitted through a very low infectious dose.

Authors+Show Affiliations

Southeastern Cooperative Wildlife Disease Study, Department of Population Health, Wildlife Health Building, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA. jbrown@vet.uga.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17984261

Citation

Brown, Justin D., et al. "Susceptibility of Wood Ducks to H5N1 Highly Pathogenic Avian Influenza Virus." Journal of Wildlife Diseases, vol. 43, no. 4, 2007, pp. 660-7.
Brown JD, Stallknecht DE, Valeika S, et al. Susceptibility of wood ducks to H5N1 highly pathogenic avian influenza virus. J Wildl Dis. 2007;43(4):660-7.
Brown, J. D., Stallknecht, D. E., Valeika, S., & Swayne, D. E. (2007). Susceptibility of wood ducks to H5N1 highly pathogenic avian influenza virus. Journal of Wildlife Diseases, 43(4), 660-7.
Brown JD, et al. Susceptibility of Wood Ducks to H5N1 Highly Pathogenic Avian Influenza Virus. J Wildl Dis. 2007;43(4):660-7. PubMed PMID: 17984261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility of wood ducks to H5N1 highly pathogenic avian influenza virus. AU - Brown,Justin D, AU - Stallknecht,David E, AU - Valeika,Steve, AU - Swayne,David E, PY - 2007/11/7/pubmed PY - 2008/1/29/medline PY - 2007/11/7/entrez SP - 660 EP - 7 JF - Journal of wildlife diseases JO - J Wildl Dis VL - 43 IS - 4 N2 - Since 2002, H5N1 highly pathogenic avian influenza (HPAI) viruses have caused mortality in numerous species of wild birds; this is atypical for avian influenza virus (AIV) infections in these avian species, especially for species within the order Anseriformes. Although these infections document the susceptibility of wild birds to H5N1 HPAI viruses and the spillover of these viruses from infected domestic birds to wild birds, it is unknown whether H5N1 HPAI viruses can persist in free-living avian populations. In a previous study, we established that wood ducks (Aix sponsa) are highly susceptible to infection with H5N1 HPAI viruses. To quantify this susceptibility and further evaluate the likelihood of H5N1 HPAI viral maintenance in a wild bird population, we determined the concentration of virus required to produce infection in wood ducks. To accomplish this, 25 wood ducks were inoculated intranasally at 12-16 wk of age with decreasing concentrations of a H5N1 HPAI virus (A/Whooper Swan/Mongolia/244/05 [H5N1]). The median infectious dose and the lethal dose of H5N1 HPAI virus in wood ducks were very low (10(0.95) and 10(1.71) median embryo infectious dose [EID(50)]/ml, respectively) and less than that of chickens (10(2.80) and 10(2.80) EID(50)/ml). These results confirm that wood ducks are highly susceptible to infection with H5N1 HPAI virus. The data from this study, combined with what is known experimentally about H5N1 HPAI virus infection in wood ducks and viral persistence in aquatic environments, suggest that the wood duck would represent a sensitive indicator species for H5N1 HPAI. Results also suggest that the potential for decreased transmission efficiency associated with reduced viral shedding (especially from the cloaca) and a loss of environmental fitness (in water), may be offset by the ability of this virus to be transmitted through a very low infectious dose. SN - 0090-3558 UR - https://www.unboundmedicine.com/medline/citation/17984261/Susceptibility_of_wood_ducks_to_H5N1_highly_pathogenic_avian_influenza_virus_ L2 - http://www.jwildlifedis.org/doi/10.7589/0090-3558-43.4.660?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -