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REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia.
Neurology. 2007 Nov 06; 69(19):1843-9.Neur

Abstract

OBJECTIVE

To assess the relationship between the presence of REM sleep behavior disorder (RBD) and the cognitive profile of nondemented patients with Parkinson disease (PD).

BACKGROUND

Cognitive impairment is an important nonmotor symptom in PD. Waking EEG slowing in nondemented PD has been related to the presence of RBD, a parasomnia affecting brainstem structures and frequently reported in PD. For this reason, RBD may be associated with cognitive impairment in PD.

METHODS

Thirty-four patients with PD (18 patients with polysomnographic-confirmed RBD and 16 patients without RBD) and 25 healthy control subjects matched for age and educational level underwent sleep laboratory recordings and a comprehensive neuropsychological assessment.

RESULTS

Patients with PD and concomitant RBD showed significantly poorer performance on standardized tests measuring episodic verbal memory, executive functions, as well as visuospatial and visuoperceptual processing compared to both patients with PD without RBD and control subjects. Patients with PD without RBD had no detectable cognitive impairment compared to controls.

CONCLUSIONS

This study shows that cognitive impairment in nondemented patients with Parkinson disease (PD) is closely related to the presence of REM sleep behavior disorder, a sleep disturbance that was not controlled for in previous studies assessing cognitive deficits in PD.

Authors+Show Affiliations

CRCPC, Centre d'Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré-Coeur de Montréal, 5400 Boul. Gouin Ouest, Montréal, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17984452

Citation

Vendette, M, et al. "REM Sleep Behavior Disorder Predicts Cognitive Impairment in Parkinson Disease Without Dementia." Neurology, vol. 69, no. 19, 2007, pp. 1843-9.
Vendette M, Gagnon JF, Décary A, et al. REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology. 2007;69(19):1843-9.
Vendette, M., Gagnon, J. F., Décary, A., Massicotte-Marquez, J., Postuma, R. B., Doyon, J., Panisset, M., & Montplaisir, J. (2007). REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology, 69(19), 1843-9.
Vendette M, et al. REM Sleep Behavior Disorder Predicts Cognitive Impairment in Parkinson Disease Without Dementia. Neurology. 2007 Nov 6;69(19):1843-9. PubMed PMID: 17984452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. AU - Vendette,M, AU - Gagnon,J-F, AU - Décary,A, AU - Massicotte-Marquez,J, AU - Postuma,R B, AU - Doyon,J, AU - Panisset,M, AU - Montplaisir,J, PY - 2007/11/7/pubmed PY - 2007/12/12/medline PY - 2007/11/7/entrez SP - 1843 EP - 9 JF - Neurology JO - Neurology VL - 69 IS - 19 N2 - OBJECTIVE: To assess the relationship between the presence of REM sleep behavior disorder (RBD) and the cognitive profile of nondemented patients with Parkinson disease (PD). BACKGROUND: Cognitive impairment is an important nonmotor symptom in PD. Waking EEG slowing in nondemented PD has been related to the presence of RBD, a parasomnia affecting brainstem structures and frequently reported in PD. For this reason, RBD may be associated with cognitive impairment in PD. METHODS: Thirty-four patients with PD (18 patients with polysomnographic-confirmed RBD and 16 patients without RBD) and 25 healthy control subjects matched for age and educational level underwent sleep laboratory recordings and a comprehensive neuropsychological assessment. RESULTS: Patients with PD and concomitant RBD showed significantly poorer performance on standardized tests measuring episodic verbal memory, executive functions, as well as visuospatial and visuoperceptual processing compared to both patients with PD without RBD and control subjects. Patients with PD without RBD had no detectable cognitive impairment compared to controls. CONCLUSIONS: This study shows that cognitive impairment in nondemented patients with Parkinson disease (PD) is closely related to the presence of REM sleep behavior disorder, a sleep disturbance that was not controlled for in previous studies assessing cognitive deficits in PD. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17984452/REM_sleep_behavior_disorder_predicts_cognitive_impairment_in_Parkinson_disease_without_dementia_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17984452 DB - PRIME DP - Unbound Medicine ER -