Tags

Type your tag names separated by a space and hit enter

In acromegaly, increased bone mineral density (BMD) is determined by GH-excess, gonadal function and gender.
Neuro Endocrinol Lett. 2007 Oct; 28(5):621-8.NE

Abstract

OBJECTIVES

The aim of our study was to evaluate bone metabolism and bone mineral density (BMD), and to indicate the main determinants of these parameters in a large group of patients with active acromegaly.

METHODS

A group of 121 active acromegalics, aged 23-80 years, from a single endocrinological center was studied. Serum GH, IGF-I, LH, FSH, PRL, estradiol/testosterone, osteocalcin (OC), type I collagen carboxyterminal telopeptide (ICTP) as well as BMD by DXA at spine L2-L4, femoral neck, Ward's triangle and trochanter were measured.

RESULTS

Serum OC and ICTP concentrations were elevated (mean+/-SEM: 31.7+/-2.2 microg/L, p<0.001; 7.3+/-0.5 microg/L, p<0.001, respectively), and positively correlated with each other, as well as with IGF-I. BMD (Z-scores) was increased at L2-L4, femoral neck and trochanter (0.35+/-0.15, p=0.016; 0.60+/-0.11, p<0.001 and 0.59+/-0.13, p<0.001; respectively). The main determinants of Z-scores and ICTP were gonadal status and gender, while of OC was IGF-I. Eugonadal acromegalics had higher than normal serum OC and ICTP, as well as Z-scores at all measured sites. Hypogonadal patients (2/3 of the population) had significantly higher serum ICTP concentrations and lower BMD at all sites, when compared to eugonadal acromegalics. Thirty five percent of hypogonadal subjects had T-score<-1. Men had significantly higher serum ICTP and lower Z-scores than women.

CONCLUSIONS

(i) In active acromegaly, enhanced IGF-I-dependent bone turnover and increased BMD is observed. (ii) In hypogonadal acromegalics, high bone resorption decreases BMD and may lead to osteoporosis. (iii) There is a smaller increase in bone resorption and greater increase in BMD in women with acromegaly than in men.

Authors+Show Affiliations

Department of Endocrinology, Centre for Postgraduate Medical Education, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17984937

Citation

Zgliczynski, Wojciech, et al. "In Acromegaly, Increased Bone Mineral Density (BMD) Is Determined By GH-excess, Gonadal Function and Gender." Neuro Endocrinology Letters, vol. 28, no. 5, 2007, pp. 621-8.
Zgliczynski W, Kochman M, Misiorowski W, et al. In acromegaly, increased bone mineral density (BMD) is determined by GH-excess, gonadal function and gender. Neuro Endocrinol Lett. 2007;28(5):621-8.
Zgliczynski, W., Kochman, M., Misiorowski, W., & Zdunowski, P. (2007). In acromegaly, increased bone mineral density (BMD) is determined by GH-excess, gonadal function and gender. Neuro Endocrinology Letters, 28(5), 621-8.
Zgliczynski W, et al. In Acromegaly, Increased Bone Mineral Density (BMD) Is Determined By GH-excess, Gonadal Function and Gender. Neuro Endocrinol Lett. 2007;28(5):621-8. PubMed PMID: 17984937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In acromegaly, increased bone mineral density (BMD) is determined by GH-excess, gonadal function and gender. AU - Zgliczynski,Wojciech, AU - Kochman,Magdalena, AU - Misiorowski,Waldemar, AU - Zdunowski,Piotr, PY - 2007/08/29/received PY - 2007/09/05/accepted PY - 2007/11/7/pubmed PY - 2008/2/12/medline PY - 2007/11/7/entrez SP - 621 EP - 8 JF - Neuro endocrinology letters JO - Neuro Endocrinol Lett VL - 28 IS - 5 N2 - OBJECTIVES: The aim of our study was to evaluate bone metabolism and bone mineral density (BMD), and to indicate the main determinants of these parameters in a large group of patients with active acromegaly. METHODS: A group of 121 active acromegalics, aged 23-80 years, from a single endocrinological center was studied. Serum GH, IGF-I, LH, FSH, PRL, estradiol/testosterone, osteocalcin (OC), type I collagen carboxyterminal telopeptide (ICTP) as well as BMD by DXA at spine L2-L4, femoral neck, Ward's triangle and trochanter were measured. RESULTS: Serum OC and ICTP concentrations were elevated (mean+/-SEM: 31.7+/-2.2 microg/L, p<0.001; 7.3+/-0.5 microg/L, p<0.001, respectively), and positively correlated with each other, as well as with IGF-I. BMD (Z-scores) was increased at L2-L4, femoral neck and trochanter (0.35+/-0.15, p=0.016; 0.60+/-0.11, p<0.001 and 0.59+/-0.13, p<0.001; respectively). The main determinants of Z-scores and ICTP were gonadal status and gender, while of OC was IGF-I. Eugonadal acromegalics had higher than normal serum OC and ICTP, as well as Z-scores at all measured sites. Hypogonadal patients (2/3 of the population) had significantly higher serum ICTP concentrations and lower BMD at all sites, when compared to eugonadal acromegalics. Thirty five percent of hypogonadal subjects had T-score<-1. Men had significantly higher serum ICTP and lower Z-scores than women. CONCLUSIONS: (i) In active acromegaly, enhanced IGF-I-dependent bone turnover and increased BMD is observed. (ii) In hypogonadal acromegalics, high bone resorption decreases BMD and may lead to osteoporosis. (iii) There is a smaller increase in bone resorption and greater increase in BMD in women with acromegaly than in men. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/17984937/In_acromegaly_increased_bone_mineral_density__BMD__is_determined_by_GH_excess_gonadal_function_and_gender_ L2 - http://www.diseaseinfosearch.org/result/162 DB - PRIME DP - Unbound Medicine ER -