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Gastrinoma--morphological aspects.
Wien Klin Wochenschr. 2007; 119(19-20):579-84.WK

Abstract

Gastrinomas are defined as gastrin producing tumors that are associated with an elevated fasting gastrin serum level, a positive gastrin secretin stimulation test and certain clinical symptoms, e.g. recurrent peptic ulcer disease and occasionally diarrhea, the so-called Zollinger-Ellison syndrome. Most gastrinomas occur in the duodenum (approx. 70%) and not in the pancreas. The duodenal gastrinomas are small, and when they occur in association with the genetic syndrome of multiple endocrine neoplasia type 1 (MEN1), they are multicentric and originate from precursor lesions. The prognosis of duodenal gastrinomas is better than that of pancreatic gastrinomas, since despite early lymph node metastasis they progress slowly to liver metastasis.

Authors+Show Affiliations

Department of Pathology, University of Kiel, Kiel, Germany. guenterkloeppel@path.uni-kiel.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17985091

Citation

Klöppel, Günter, and Martin Anlauf. "Gastrinoma--morphological Aspects." Wiener Klinische Wochenschrift, vol. 119, no. 19-20, 2007, pp. 579-84.
Klöppel G, Anlauf M. Gastrinoma--morphological aspects. Wien Klin Wochenschr. 2007;119(19-20):579-84.
Klöppel, G., & Anlauf, M. (2007). Gastrinoma--morphological aspects. Wiener Klinische Wochenschrift, 119(19-20), 579-84.
Klöppel G, Anlauf M. Gastrinoma--morphological Aspects. Wien Klin Wochenschr. 2007;119(19-20):579-84. PubMed PMID: 17985091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrinoma--morphological aspects. AU - Klöppel,Günter, AU - Anlauf,Martin, PY - 2007/11/7/pubmed PY - 2008/3/5/medline PY - 2007/11/7/entrez SP - 579 EP - 84 JF - Wiener klinische Wochenschrift JO - Wien. Klin. Wochenschr. VL - 119 IS - 19-20 N2 - Gastrinomas are defined as gastrin producing tumors that are associated with an elevated fasting gastrin serum level, a positive gastrin secretin stimulation test and certain clinical symptoms, e.g. recurrent peptic ulcer disease and occasionally diarrhea, the so-called Zollinger-Ellison syndrome. Most gastrinomas occur in the duodenum (approx. 70%) and not in the pancreas. The duodenal gastrinomas are small, and when they occur in association with the genetic syndrome of multiple endocrine neoplasia type 1 (MEN1), they are multicentric and originate from precursor lesions. The prognosis of duodenal gastrinomas is better than that of pancreatic gastrinomas, since despite early lymph node metastasis they progress slowly to liver metastasis. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/17985091/Gastrinoma__morphological_aspects_ L2 - https://dx.doi.org/10.1007/s00508-007-0885-1 DB - PRIME DP - Unbound Medicine ER -