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Localisation and staging of gastrin producing tumours using cross-sectional imaging modalities.
Wien Klin Wochenschr. 2007; 119(19-20):588-92.WK

Abstract

Cross sectional imaging in the assessment of gastrinomas has three major applications: Tumor localization (sporadic gastrinoma, MEN I) in patients undergoing primary or secondary surgery. Staging of metastasized tumors, especially assessment of lymph nodes and liver metastases, possibly including a risk analysis prior to liver resection. Post-surgery follow-up and monitoring of bio- or chemotherapy. Detection of primary tumors is strongly correlated with their size. However, the sensitivity of surgical assessment of the mostly small tumors by experienced surgeons is much higher than that of any imaging modality. Of all imaging modalities, endoultrasonography (EUS) followed by Somatostatin receptor scintigraphy (SRS) is the most sensitive modality for the assessment of pancreatic tumors in asymptomatic patients suffering from a MEN-I syndrome. Scintigraphy has the highest sensitivity in tumors of symptomatic patients and in the assessment of metastases. CT and MRI are only second line diagnostic modalities. Their sensitivity is largely dependent on the selection of patients. As a potential application, 3D reconstruction of nearly isotropic CT data sets for the risk assessment prior to liver resection is currently developing. Due to the absent radiation exposure, MRI is increasingly utilized to monitor the response of metastases under systemic therapy, e.g. in clinical trials.

Authors+Show Affiliations

Department of Diagnostic Radiology, University Hospital Giessen and Marburg GmbH, Marburg, Germany. klose@med.uni-marburg.deNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

17985093

Citation

Klose, Klaus Jochen, and Johannes T. Heverhagen. "Localisation and Staging of Gastrin Producing Tumours Using Cross-sectional Imaging Modalities." Wiener Klinische Wochenschrift, vol. 119, no. 19-20, 2007, pp. 588-92.
Klose KJ, Heverhagen JT. Localisation and staging of gastrin producing tumours using cross-sectional imaging modalities. Wien Klin Wochenschr. 2007;119(19-20):588-92.
Klose, K. J., & Heverhagen, J. T. (2007). Localisation and staging of gastrin producing tumours using cross-sectional imaging modalities. Wiener Klinische Wochenschrift, 119(19-20), 588-92.
Klose KJ, Heverhagen JT. Localisation and Staging of Gastrin Producing Tumours Using Cross-sectional Imaging Modalities. Wien Klin Wochenschr. 2007;119(19-20):588-92. PubMed PMID: 17985093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Localisation and staging of gastrin producing tumours using cross-sectional imaging modalities. AU - Klose,Klaus Jochen, AU - Heverhagen,Johannes T, PY - 2007/11/7/pubmed PY - 2008/3/5/medline PY - 2007/11/7/entrez SP - 588 EP - 92 JF - Wiener klinische Wochenschrift JO - Wien. Klin. Wochenschr. VL - 119 IS - 19-20 N2 - Cross sectional imaging in the assessment of gastrinomas has three major applications: Tumor localization (sporadic gastrinoma, MEN I) in patients undergoing primary or secondary surgery. Staging of metastasized tumors, especially assessment of lymph nodes and liver metastases, possibly including a risk analysis prior to liver resection. Post-surgery follow-up and monitoring of bio- or chemotherapy. Detection of primary tumors is strongly correlated with their size. However, the sensitivity of surgical assessment of the mostly small tumors by experienced surgeons is much higher than that of any imaging modality. Of all imaging modalities, endoultrasonography (EUS) followed by Somatostatin receptor scintigraphy (SRS) is the most sensitive modality for the assessment of pancreatic tumors in asymptomatic patients suffering from a MEN-I syndrome. Scintigraphy has the highest sensitivity in tumors of symptomatic patients and in the assessment of metastases. CT and MRI are only second line diagnostic modalities. Their sensitivity is largely dependent on the selection of patients. As a potential application, 3D reconstruction of nearly isotropic CT data sets for the risk assessment prior to liver resection is currently developing. Due to the absent radiation exposure, MRI is increasingly utilized to monitor the response of metastases under systemic therapy, e.g. in clinical trials. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/17985093/Localisation_and_staging_of_gastrin_producing_tumours_using_cross_sectional_imaging_modalities_ L2 - https://dx.doi.org/10.1007/s00508-007-0886-0 DB - PRIME DP - Unbound Medicine ER -