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Reduced striatal tyrosine hydroxylase in incidental Lewy body disease.
Acta Neuropathol. 2008 Apr; 115(4):445-51.AN

Abstract

Incidental Lewy body disease (ILBD) is the term used when Lewy bodies are found in the nervous system of subjects without clinically documented parkinsonism or dementia. The prevalence of ILBD in the elderly population has been estimated at between 3.8 and 30%, depending on subject age and anatomical site of sampling. It has been speculated that ILBD represents the preclinical stage of Parkinson's disease (PD) and/or dementia with Lewy bodies (DLB). Studies of ILBD could potentially identify early diagnostic signs of these disorders. At present, however, it is impossible to know whether ILBD is a precursor to PD or DLB or is just a benign finding of normal aging. We hypothesized that, if ILBD represents an early stage of PD or DLB, it should be associated with depletion of striatal dopaminergic markers. Eleven subjects with ILBD and 27 control subjects were studied. The ILBD subjects ranged in age from 74 to 96 years (mean 86.5) while the control subjects' age ranged from 75 to 102 years (mean 86.7). Controls and subjects did not differ in terms of age, postmortem interval, gender distribution, medical history conditions, brain weight, neuritic plaque density or Braak neurofibrillary stage. Quantitative ELISA measurement of striatal tyrosine hydroxylase (TH), the principal enzyme for dopamine synthesis, showed a 49.8% (P = 0.01) reduction in ILBD cases, as compared with control cases. The finding suggests that ILBD is not a benign condition but is likely a precursor to PD and/or DLB.

Authors+Show Affiliations

Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA. thomas.beach@sunhealth.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17985144

Citation

Beach, Thomas Gerald, et al. "Reduced Striatal Tyrosine Hydroxylase in Incidental Lewy Body Disease." Acta Neuropathologica, vol. 115, no. 4, 2008, pp. 445-51.
Beach TG, Adler CH, Sue LI, et al. Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. Acta Neuropathol. 2008;115(4):445-51.
Beach, T. G., Adler, C. H., Sue, L. I., Peirce, J. B., Bachalakuri, J., Dalsing-Hernandez, J. E., Lue, L. F., Caviness, J. N., Connor, D. J., Sabbagh, M. N., & Walker, D. G. (2008). Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. Acta Neuropathologica, 115(4), 445-51.
Beach TG, et al. Reduced Striatal Tyrosine Hydroxylase in Incidental Lewy Body Disease. Acta Neuropathol. 2008;115(4):445-51. PubMed PMID: 17985144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. AU - Beach,Thomas Gerald, AU - Adler,Charles H, AU - Sue,Lucia I, AU - Peirce,Jeffrey B, AU - Bachalakuri,Jyothi, AU - Dalsing-Hernandez,Jessica E, AU - Lue,Lih Fen, AU - Caviness,John N, AU - Connor,Donald J, AU - Sabbagh,Marwan N, AU - Walker,Douglas G, Y1 - 2007/11/06/ PY - 2007/08/24/received PY - 2007/10/20/accepted PY - 2007/10/17/revised PY - 2007/11/7/pubmed PY - 2008/8/2/medline PY - 2007/11/7/entrez SP - 445 EP - 51 JF - Acta neuropathologica JO - Acta Neuropathol VL - 115 IS - 4 N2 - Incidental Lewy body disease (ILBD) is the term used when Lewy bodies are found in the nervous system of subjects without clinically documented parkinsonism or dementia. The prevalence of ILBD in the elderly population has been estimated at between 3.8 and 30%, depending on subject age and anatomical site of sampling. It has been speculated that ILBD represents the preclinical stage of Parkinson's disease (PD) and/or dementia with Lewy bodies (DLB). Studies of ILBD could potentially identify early diagnostic signs of these disorders. At present, however, it is impossible to know whether ILBD is a precursor to PD or DLB or is just a benign finding of normal aging. We hypothesized that, if ILBD represents an early stage of PD or DLB, it should be associated with depletion of striatal dopaminergic markers. Eleven subjects with ILBD and 27 control subjects were studied. The ILBD subjects ranged in age from 74 to 96 years (mean 86.5) while the control subjects' age ranged from 75 to 102 years (mean 86.7). Controls and subjects did not differ in terms of age, postmortem interval, gender distribution, medical history conditions, brain weight, neuritic plaque density or Braak neurofibrillary stage. Quantitative ELISA measurement of striatal tyrosine hydroxylase (TH), the principal enzyme for dopamine synthesis, showed a 49.8% (P = 0.01) reduction in ILBD cases, as compared with control cases. The finding suggests that ILBD is not a benign condition but is likely a precursor to PD and/or DLB. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/17985144/Reduced_striatal_tyrosine_hydroxylase_in_incidental_Lewy_body_disease_ L2 - https://dx.doi.org/10.1007/s00401-007-0313-7 DB - PRIME DP - Unbound Medicine ER -