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Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up.
Dig Dis Sci 2008; 53(6):1582-8DD

Abstract

The prevalence of the recently described deamidated gliadin peptide antibodies was compared with that of the routinely used antigliadin, antiendomysial, and tissue transglutaminase antibodies in the sera of 128 untreated celiac patients and 134 controls. Sensitivity and specificity for celiac disease were 83.6 and 90.3% for IgA and 84.4 and 98.5% for IgG antibodies to deamidated gliadin peptides. The new test displayed higher diagnostic accuracy than antigliadin antibodies and, although less sensitive than antiendomysial and tissue transglutaminase antibodies, showed significantly higher specificity than tissue transglutaminase antibodies (P < 0.001). Persistence of peptide antibodies after gluten withdrawal was an expression of low compliance with the diet and of the lack of improvement of the intestinal mucosa. The combined use of tissue transglutaminase and deamidated gliadin peptide antibodies seems to be a very useful tool for celiac disease diagnosis. Moreover, antibodies to deamidated gliadin peptides can be helpful in disease follow-up.

Authors+Show Affiliations

Department of Gastroenterology and Internal Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, Bologna 40138, Italy. uvolta@aosp.bo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17985240

Citation

Volta, Umberto, et al. "Usefulness of Antibodies to Deamidated Gliadin Peptides in Celiac Disease Diagnosis and Follow-up." Digestive Diseases and Sciences, vol. 53, no. 6, 2008, pp. 1582-8.
Volta U, Granito A, Fiorini E, et al. Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up. Dig Dis Sci. 2008;53(6):1582-8.
Volta, U., Granito, A., Fiorini, E., Parisi, C., Piscaglia, M., Pappas, G., ... Bianchi, F. B. (2008). Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up. Digestive Diseases and Sciences, 53(6), pp. 1582-8.
Volta U, et al. Usefulness of Antibodies to Deamidated Gliadin Peptides in Celiac Disease Diagnosis and Follow-up. Dig Dis Sci. 2008;53(6):1582-8. PubMed PMID: 17985240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up. AU - Volta,Umberto, AU - Granito,Alessandro, AU - Fiorini,Erica, AU - Parisi,Claudia, AU - Piscaglia,Maria, AU - Pappas,Georgios, AU - Muratori,Paolo, AU - Bianchi,Francesco B, PY - 2007/09/03/received PY - 2007/09/26/accepted PY - 2007/11/7/pubmed PY - 2008/8/6/medline PY - 2007/11/7/entrez SP - 1582 EP - 8 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 53 IS - 6 N2 - The prevalence of the recently described deamidated gliadin peptide antibodies was compared with that of the routinely used antigliadin, antiendomysial, and tissue transglutaminase antibodies in the sera of 128 untreated celiac patients and 134 controls. Sensitivity and specificity for celiac disease were 83.6 and 90.3% for IgA and 84.4 and 98.5% for IgG antibodies to deamidated gliadin peptides. The new test displayed higher diagnostic accuracy than antigliadin antibodies and, although less sensitive than antiendomysial and tissue transglutaminase antibodies, showed significantly higher specificity than tissue transglutaminase antibodies (P < 0.001). Persistence of peptide antibodies after gluten withdrawal was an expression of low compliance with the diet and of the lack of improvement of the intestinal mucosa. The combined use of tissue transglutaminase and deamidated gliadin peptide antibodies seems to be a very useful tool for celiac disease diagnosis. Moreover, antibodies to deamidated gliadin peptides can be helpful in disease follow-up. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/17985240/Usefulness_of_antibodies_to_deamidated_gliadin_peptides_in_celiac_disease_diagnosis_and_follow_up_ L2 - https://doi.org/10.1007/s10620-007-0058-0 DB - PRIME DP - Unbound Medicine ER -