Tags

Type your tag names separated by a space and hit enter

Retinol-binding protein in nonobese women with polycystic ovary syndrome.
Clin Endocrinol (Oxf). 2008 May; 68(5):786-90.CE

Abstract

OBJECTIVE

Although polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance, cardiovascular disease and various metabolic diseases, the mechanisms linking PCOS to metabolic changes are not fully understood. Retinol-binding protein (RBP) was recently reported as an adipocytokine that may link insulin resistance and lipid metabolism. The aim of this study was to investigate the potential role of RBP in women with PCOS.

RESEARCH DESIGN AND METHODS

Fifty women with PCOS and 40 healthy women, all of whom were age- and weight-matched, were studied. Blood was obtained to determine RBP levels as well as metabolic and hormonal parameters, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated for each subject.

RESULTS

The RBP levels were higher (P < 0.01) in women with PCOS after adjusting for age, body mass index (BMI), mean blood pressure, triglyceride (TG), high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, fasting glucose, fasting insulin, estimated glomerular filtration rate (GFR), LH/FSH, total testosterone and SHBG levels. PCOS status was the strongest predictor of elevated RBP levels. In both the PCOS and control groups, RBP levels were significantly correlated with HOMA-IR (P = 0.03 in the PCOS group; P = 0.01 in controls). In addition, RBP levels were significantly correlated with total cholesterol, LDL-cholesterol and TG levels in PCOS (P < 0.01, P < 0.01 and P = 0.01, respectively).

CONCLUSIONS

Higher RBP levels in the PCOS group, when compared to the non-PCOS group, were observed, and this difference may play a role in the pathophysiology found in women with PCOS. Further studies are needed to clarify the role of RBP in these women.

Authors+Show Affiliations

Lee JW
Department of Family Medicine, Yonsei University, College of Medicine, Yongdong Severance Hospital, Seoul, Korea.
Im JA
No affiliation info available
Lee DC
No affiliation info available
Lee HR
No affiliation info available
Shim JY
No affiliation info available

MeSH

Body Mass IndexFemaleHumansInsulin ResistanceObesityPolycystic Ovary SyndromeRetinol-Binding Proteins

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17986278

Citation

Lee, Ji-Won, et al. "Retinol-binding Protein in Nonobese Women With Polycystic Ovary Syndrome." Clinical Endocrinology, vol. 68, no. 5, 2008, pp. 786-90.
Lee JW, Im JA, Lee DC, et al. Retinol-binding protein in nonobese women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2008;68(5):786-90.
Lee, J. W., Im, J. A., Lee, D. C., Lee, H. R., & Shim, J. Y. (2008). Retinol-binding protein in nonobese women with polycystic ovary syndrome. Clinical Endocrinology, 68(5), 786-90.
Lee JW, et al. Retinol-binding Protein in Nonobese Women With Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). 2008;68(5):786-90. PubMed PMID: 17986278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinol-binding protein in nonobese women with polycystic ovary syndrome. AU - Lee,Ji-Won, AU - Im,Jee-Aee, AU - Lee,Duk-Chul, AU - Lee,Hye-Ree, AU - Shim,Jae-Yong, Y1 - 2007/11/06/ PY - 2007/11/8/pubmed PY - 2009/9/16/medline PY - 2007/11/8/entrez SP - 786 EP - 90 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 68 IS - 5 N2 - OBJECTIVE: Although polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance, cardiovascular disease and various metabolic diseases, the mechanisms linking PCOS to metabolic changes are not fully understood. Retinol-binding protein (RBP) was recently reported as an adipocytokine that may link insulin resistance and lipid metabolism. The aim of this study was to investigate the potential role of RBP in women with PCOS. RESEARCH DESIGN AND METHODS: Fifty women with PCOS and 40 healthy women, all of whom were age- and weight-matched, were studied. Blood was obtained to determine RBP levels as well as metabolic and hormonal parameters, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated for each subject. RESULTS: The RBP levels were higher (P < 0.01) in women with PCOS after adjusting for age, body mass index (BMI), mean blood pressure, triglyceride (TG), high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, fasting glucose, fasting insulin, estimated glomerular filtration rate (GFR), LH/FSH, total testosterone and SHBG levels. PCOS status was the strongest predictor of elevated RBP levels. In both the PCOS and control groups, RBP levels were significantly correlated with HOMA-IR (P = 0.03 in the PCOS group; P = 0.01 in controls). In addition, RBP levels were significantly correlated with total cholesterol, LDL-cholesterol and TG levels in PCOS (P < 0.01, P < 0.01 and P = 0.01, respectively). CONCLUSIONS: Higher RBP levels in the PCOS group, when compared to the non-PCOS group, were observed, and this difference may play a role in the pathophysiology found in women with PCOS. Further studies are needed to clarify the role of RBP in these women. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/17986278/Retinol_binding_protein_in_nonobese_women_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -