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Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency.
Biosci Biotechnol Biochem. 2007 Nov; 71(11):2841-4.BB

Abstract

A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation.

Authors+Show Affiliations

Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Japan. normutoh@inst-hsc.jpNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17986764

Citation

Mutoh, Norihiro, and Satoko Kitajima. "Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement By Sir2 Deficiency." Bioscience, Biotechnology, and Biochemistry, vol. 71, no. 11, 2007, pp. 2841-4.
Mutoh N, Kitajima S. Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency. Biosci Biotechnol Biochem. 2007;71(11):2841-4.
Mutoh, N., & Kitajima, S. (2007). Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency. Bioscience, Biotechnology, and Biochemistry, 71(11), 2841-4.
Mutoh N, Kitajima S. Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement By Sir2 Deficiency. Biosci Biotechnol Biochem. 2007;71(11):2841-4. PubMed PMID: 17986764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency. AU - Mutoh,Norihiro, AU - Kitajima,Satoko, Y1 - 2007/11/07/ PY - 2007/11/8/pubmed PY - 2008/2/12/medline PY - 2007/11/8/entrez SP - 2841 EP - 4 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 71 IS - 11 N2 - A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/17986764/Accelerated_chronological_aging_of_a_mutant_fission_yeast_deficient_in_both_glutathione_and_superoxide_dismutase_having_cu_and_zn_as_cofactors_and_its_enhancement_by_sir2_deficiency_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/70307?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -