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Reference and cut-off values for serum ferritin, mean cell volume, and hemoglobin to diagnose iron deficiency in infants aged 9 to 12 months.
Medicina (Kaunas). 2007; 43(9):698-702.M

Abstract

BACKGROUND

The number of different laboratory tests and reference values are used to diagnose iron deficiency, but there is no agreement regarding the diagnostic criteria for infants. Aim of study. To establish reference values for serum ferritin, mean cell volume, and hemoglobin in infants aged from 9 to 12 months in Estonia and to evaluate the diagnostic characteristics of serum ferritin, mean cell volume, and hemoglobin in the diagnosis of iron deficiency.

METHODS

Altogether 195 healthy infants aged 9-12 months participated in the study. They were randomly selected out of 300 families from seven different counties from all over Estonia. Serum ferritin, hemoglobin, soluble transferrin receptor (sTfR) levels and mean cell volume were measured. The best cut-off values for serum ferritin, mean cell volume, and hemoglobin to diagnose iron deficiency, defined by sTfR>2.45 mg/L (n=25), were determined by receiver operating characteristic curves.

RESULTS

The mean and reference values (5th and 95th centiles) for ferritin was 24 microg/L (4-55), 73 fl (68-80) for mean cell volume, and 112 g/L (101-128) for hemoglobin. The best cut-off values to diagnose iron deficiency were <10.9 microg/L for serum ferritin (sensitivity of 83% and specificity of 80%), <71 fl for mean cell volume (86% and 83%, respectively), and <107 g/L for hemoglobin (67% and 87%, respectively). The sensitivity and specificity of serum ferritin and mean cell volume in the diagnosis of iron deficiency were better than those of hemoglobin.

CONCLUSION

For the diagnosis of iron deficiency in infants aged 9-12 months, the cut-off values of <10.9 microg/L and <71 fl should be used for serum ferritin and mean cell volume, respectively.

Authors+Show Affiliations

Department of Pediatrics, University of Tartu, Lunini 6, 51014 Tartu, Estonia. neve.vendt@kliinikum.eeNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17986842

Citation

Vendt, Neve, et al. "Reference and Cut-off Values for Serum Ferritin, Mean Cell Volume, and Hemoglobin to Diagnose Iron Deficiency in Infants Aged 9 to 12 Months." Medicina (Kaunas, Lithuania), vol. 43, no. 9, 2007, pp. 698-702.
Vendt N, Talvik T, Kool P, et al. Reference and cut-off values for serum ferritin, mean cell volume, and hemoglobin to diagnose iron deficiency in infants aged 9 to 12 months. Medicina (Kaunas). 2007;43(9):698-702.
Vendt, N., Talvik, T., Kool, P., Leedo, S., Tomberg, K., Tillmann, V., & Grünberg, H. (2007). Reference and cut-off values for serum ferritin, mean cell volume, and hemoglobin to diagnose iron deficiency in infants aged 9 to 12 months. Medicina (Kaunas, Lithuania), 43(9), 698-702.
Vendt N, et al. Reference and Cut-off Values for Serum Ferritin, Mean Cell Volume, and Hemoglobin to Diagnose Iron Deficiency in Infants Aged 9 to 12 Months. Medicina (Kaunas). 2007;43(9):698-702. PubMed PMID: 17986842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reference and cut-off values for serum ferritin, mean cell volume, and hemoglobin to diagnose iron deficiency in infants aged 9 to 12 months. AU - Vendt,Neve, AU - Talvik,Tiina, AU - Kool,Pille, AU - Leedo,Sirje, AU - Tomberg,Karel, AU - Tillmann,Vallo, AU - Grünberg,Heli, PY - 2007/11/8/pubmed PY - 2008/1/11/medline PY - 2007/11/8/entrez SP - 698 EP - 702 JF - Medicina (Kaunas, Lithuania) JO - Medicina (Kaunas) VL - 43 IS - 9 N2 - BACKGROUND: The number of different laboratory tests and reference values are used to diagnose iron deficiency, but there is no agreement regarding the diagnostic criteria for infants. Aim of study. To establish reference values for serum ferritin, mean cell volume, and hemoglobin in infants aged from 9 to 12 months in Estonia and to evaluate the diagnostic characteristics of serum ferritin, mean cell volume, and hemoglobin in the diagnosis of iron deficiency. METHODS: Altogether 195 healthy infants aged 9-12 months participated in the study. They were randomly selected out of 300 families from seven different counties from all over Estonia. Serum ferritin, hemoglobin, soluble transferrin receptor (sTfR) levels and mean cell volume were measured. The best cut-off values for serum ferritin, mean cell volume, and hemoglobin to diagnose iron deficiency, defined by sTfR>2.45 mg/L (n=25), were determined by receiver operating characteristic curves. RESULTS: The mean and reference values (5th and 95th centiles) for ferritin was 24 microg/L (4-55), 73 fl (68-80) for mean cell volume, and 112 g/L (101-128) for hemoglobin. The best cut-off values to diagnose iron deficiency were <10.9 microg/L for serum ferritin (sensitivity of 83% and specificity of 80%), <71 fl for mean cell volume (86% and 83%, respectively), and <107 g/L for hemoglobin (67% and 87%, respectively). The sensitivity and specificity of serum ferritin and mean cell volume in the diagnosis of iron deficiency were better than those of hemoglobin. CONCLUSION: For the diagnosis of iron deficiency in infants aged 9-12 months, the cut-off values of <10.9 microg/L and <71 fl should be used for serum ferritin and mean cell volume, respectively. SN - 1648-9144 UR - https://www.unboundmedicine.com/medline/citation/17986842/Reference_and_cut_off_values_for_serum_ferritin_mean_cell_volume_and_hemoglobin_to_diagnose_iron_deficiency_in_infants_aged_9_to_12_months_ L2 - http://medicina.lsmuni.lt/med/0709/0709-04e.htm DB - PRIME DP - Unbound Medicine ER -