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Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany.
Br J Cancer. 2007 Dec 03; 97(11):1486-92.BJ

Abstract

Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically confirmed incident CRC and 246 controls in a population-based case-control study in Germany (DACHS study). Ever use of HRT was strongly associated with reduction of CRC risk (adjusted odds ratio 0.41, 95% confidence interval 0.25-0.67). Among nonusers of HRT, risk of CRC was strongly increased in women with BMI 27 to <30 kg m(-2) (2.76, 1.07-7.12) and obese women (3.30, 1.25-8.72), when compared with women with BMI <23 kg m(-2) (P for trend <0.01). BMI was not associated with risk of CRC among HRT users (P for interaction <0.01). In contrast to most other studies, a positive association of BMI and CRC risk was found among nonusers of HRT, but not among users of HRT. The reasons for the inconsistency of results regarding the potential risk modifying effect of postmenopausal hormones in the association of BMI with CRC remain inconclusive and require further study.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. m.hoffmeister@dkfz.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17987040

Citation

Hoffmeister, M, et al. "Hormone Replacement Therapy, Body Mass, and the Risk of Colorectal Cancer Among Postmenopausal Women From Germany." British Journal of Cancer, vol. 97, no. 11, 2007, pp. 1486-92.
Hoffmeister M, Raum E, Winter J, et al. Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany. Br J Cancer. 2007;97(11):1486-92.
Hoffmeister, M., Raum, E., Winter, J., Chang-Claude, J., & Brenner, H. (2007). Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany. British Journal of Cancer, 97(11), 1486-92.
Hoffmeister M, et al. Hormone Replacement Therapy, Body Mass, and the Risk of Colorectal Cancer Among Postmenopausal Women From Germany. Br J Cancer. 2007 Dec 3;97(11):1486-92. PubMed PMID: 17987040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany. AU - Hoffmeister,M, AU - Raum,E, AU - Winter,J, AU - Chang-Claude,J, AU - Brenner,H, Y1 - 2007/11/06/ PY - 2007/11/8/pubmed PY - 2008/1/25/medline PY - 2007/11/8/entrez SP - 1486 EP - 92 JF - British journal of cancer JO - Br. J. Cancer VL - 97 IS - 11 N2 - Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically confirmed incident CRC and 246 controls in a population-based case-control study in Germany (DACHS study). Ever use of HRT was strongly associated with reduction of CRC risk (adjusted odds ratio 0.41, 95% confidence interval 0.25-0.67). Among nonusers of HRT, risk of CRC was strongly increased in women with BMI 27 to <30 kg m(-2) (2.76, 1.07-7.12) and obese women (3.30, 1.25-8.72), when compared with women with BMI <23 kg m(-2) (P for trend <0.01). BMI was not associated with risk of CRC among HRT users (P for interaction <0.01). In contrast to most other studies, a positive association of BMI and CRC risk was found among nonusers of HRT, but not among users of HRT. The reasons for the inconsistency of results regarding the potential risk modifying effect of postmenopausal hormones in the association of BMI with CRC remain inconclusive and require further study. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/17987040/Hormone_replacement_therapy_body_mass_and_the_risk_of_colorectal_cancer_among_postmenopausal_women_from_Germany_ L2 - http://dx.doi.org/10.1038/sj.bjc.6604066 DB - PRIME DP - Unbound Medicine ER -