Tags

Type your tag names separated by a space and hit enter

Benhamycin, novel alkaloid from terrestrial Streptomyces sp.
Nat Prod Res. 2007 Nov; 21(13):1205-11.NP

Abstract

During our screening for bioactive natural compounds from microorganisms, a novel alkaloid has been isolated from a terrestrial Streptomyces sp. isolate NR12, and named as benhamycin (1). This was along with the known metabolites, uracil, thymine, p-hydroxybenzoic acid, 2'-deoxyuridin, tryptophol, indolyl-3-carboxylic acid, and indolyl-3-carbaldehyde. Chemical structure of the novel compound was determined by detailed analysis of its spectroscopic data (extensive NMR experiments, 1 & 2D, MS spectroscopy, and MS high resolution). Structurally, Benhamycin (1) is a pentacyclic aromatic compound bearing an acridine moiety lactamized with benzene. Biological studies showed that the strain extract was moderately active against Gram-positive, Gram-negative bacteria and fungi.

Authors+Show Affiliations

Shaaban M
Department of Chemistry of Natural Compounds, Division of Pharmaceutical Industries, National Research Centre, Dokki-Cairo, Egypt. mshaaba@yahoo.com
Abdel-Aziz MS
No affiliation info available

MeSH

AcridinesAlkaloidsAnti-Bacterial AgentsAntifungal AgentsAspergillus nigerBacillus subtilisEscherichia coliMicrobial Sensitivity TestsNuclear Magnetic Resonance, BiomolecularSpectrometry, Mass, Electrospray IonizationSpectrophotometry, InfraredSpectrophotometry, UltravioletStreptomyces

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17987502

Citation

Shaaban, Mohamed, and Mohamed S. Abdel-Aziz. "Benhamycin, Novel Alkaloid From Terrestrial Streptomyces Sp." Natural Product Research, vol. 21, no. 13, 2007, pp. 1205-11.
Shaaban M, Abdel-Aziz MS. Benhamycin, novel alkaloid from terrestrial Streptomyces sp. Nat Prod Res. 2007;21(13):1205-11.
Shaaban, M., & Abdel-Aziz, M. S. (2007). Benhamycin, novel alkaloid from terrestrial Streptomyces sp. Natural Product Research, 21(13), 1205-11.
Shaaban M, Abdel-Aziz MS. Benhamycin, Novel Alkaloid From Terrestrial Streptomyces Sp. Nat Prod Res. 2007;21(13):1205-11. PubMed PMID: 17987502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benhamycin, novel alkaloid from terrestrial Streptomyces sp. AU - Shaaban,Mohamed, AU - Abdel-Aziz,Mohamed S, PY - 2007/11/8/pubmed PY - 2008/1/23/medline PY - 2007/11/8/entrez SP - 1205 EP - 11 JF - Natural product research JO - Nat Prod Res VL - 21 IS - 13 N2 - During our screening for bioactive natural compounds from microorganisms, a novel alkaloid has been isolated from a terrestrial Streptomyces sp. isolate NR12, and named as benhamycin (1). This was along with the known metabolites, uracil, thymine, p-hydroxybenzoic acid, 2'-deoxyuridin, tryptophol, indolyl-3-carboxylic acid, and indolyl-3-carbaldehyde. Chemical structure of the novel compound was determined by detailed analysis of its spectroscopic data (extensive NMR experiments, 1 & 2D, MS spectroscopy, and MS high resolution). Structurally, Benhamycin (1) is a pentacyclic aromatic compound bearing an acridine moiety lactamized with benzene. Biological studies showed that the strain extract was moderately active against Gram-positive, Gram-negative bacteria and fungi. SN - 1478-6419 UR - https://www.unboundmedicine.com/medline/citation/17987502/Benhamycin_novel_alkaloid_from_terrestrial_Streptomyces_sp_ DB - PRIME DP - Unbound Medicine ER -