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Prevalence of 25(OH) vitamin D (calcidiol) deficiency at time of renal transplantation: a prospective study.
Clin Transplant. 2007 Nov-Dec; 21(6):683-8.CT

Abstract

25(OH) Vitamin D (calcidiol) is the major circulating form of vitamin D and is considered the most reliable measure of vitamin D status. Adequate vitamin D status is important for bone health but there is increasing evidence that low serum concentrations of calcidiol (<30 ng/mL) are associated with many adverse health outcomes in the general population. Little is known about calcidiol status at the time of renal transplantation, a period when bone loss is greatest and immunosuppression is highest. We prospectively measured serum calcidiol and parathyroid hormone immediately after transplant from March 2005 onwards. Of 112 patients studied, 29% had calcidiol deficiency (<10 ng/mL), 59% had calcidiol insufficiency (10-29 ng/mL) and only 12% of patients had a normal calcidiol concentration (>30 ng/mL). The prevalence of calcidiol deficiency in black recipients was extremely high at 41%. Serum calcidiol tended to be lower in winter than other seasons. In conclusion, the prevalence of 25(OH) vitamin D (calcidiol) deficiency/insufficiency at the time of renal transplant is very high. The clinical effects of this deficiency/insufficiency deserve further study.

Authors+Show Affiliations

Renal Division, Brigham and Women's Hospital, Boston, MA, USA. dmsadlier@gmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17988259

Citation

Sadlier, D M., and C C. Magee. "Prevalence of 25(OH) Vitamin D (calcidiol) Deficiency at Time of Renal Transplantation: a Prospective Study." Clinical Transplantation, vol. 21, no. 6, 2007, pp. 683-8.
Sadlier DM, Magee CC. Prevalence of 25(OH) vitamin D (calcidiol) deficiency at time of renal transplantation: a prospective study. Clin Transplant. 2007;21(6):683-8.
Sadlier, D. M., & Magee, C. C. (2007). Prevalence of 25(OH) vitamin D (calcidiol) deficiency at time of renal transplantation: a prospective study. Clinical Transplantation, 21(6), 683-8.
Sadlier DM, Magee CC. Prevalence of 25(OH) Vitamin D (calcidiol) Deficiency at Time of Renal Transplantation: a Prospective Study. Clin Transplant. 2007 Nov-Dec;21(6):683-8. PubMed PMID: 17988259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of 25(OH) vitamin D (calcidiol) deficiency at time of renal transplantation: a prospective study. AU - Sadlier,D M, AU - Magee,C C, PY - 2007/11/9/pubmed PY - 2008/2/8/medline PY - 2007/11/9/entrez SP - 683 EP - 8 JF - Clinical transplantation JO - Clin Transplant VL - 21 IS - 6 N2 - 25(OH) Vitamin D (calcidiol) is the major circulating form of vitamin D and is considered the most reliable measure of vitamin D status. Adequate vitamin D status is important for bone health but there is increasing evidence that low serum concentrations of calcidiol (<30 ng/mL) are associated with many adverse health outcomes in the general population. Little is known about calcidiol status at the time of renal transplantation, a period when bone loss is greatest and immunosuppression is highest. We prospectively measured serum calcidiol and parathyroid hormone immediately after transplant from March 2005 onwards. Of 112 patients studied, 29% had calcidiol deficiency (<10 ng/mL), 59% had calcidiol insufficiency (10-29 ng/mL) and only 12% of patients had a normal calcidiol concentration (>30 ng/mL). The prevalence of calcidiol deficiency in black recipients was extremely high at 41%. Serum calcidiol tended to be lower in winter than other seasons. In conclusion, the prevalence of 25(OH) vitamin D (calcidiol) deficiency/insufficiency at the time of renal transplant is very high. The clinical effects of this deficiency/insufficiency deserve further study. SN - 0902-0063 UR - https://www.unboundmedicine.com/medline/citation/17988259/Prevalence_of_25_OH__vitamin_D__calcidiol__deficiency_at_time_of_renal_transplantation:_a_prospective_study_ L2 - https://doi.org/10.1111/j.1399-0012.2007.00696.x DB - PRIME DP - Unbound Medicine ER -