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Bipolar obsessive-compulsive disorder and personality disorders.
Bipolar Disord. 2007 Nov; 9(7):722-9.BD

Abstract

OBJECTIVES

Relatively few systematic data exist on the clinical impact of bipolar comorbidity in obsessive-compulsive disorder (OCD) and no studies have investigated the influence of such a comorbidity on the prevalence and pattern of Axis II comorbidity. The aim of the present study was to explore the comorbidity of personality disorders in a group of patients with OCD and comorbid bipolar disorder (BD).

METHODS

The sample consisted of 204 subjects with a principal diagnosis of OCD (DSM-IV) and a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score>or=16 recruited from all patients consecutively referred to the Anxiety and Mood Disorders Unit, Department of Neuroscience, University of Turin over a period of 5 years (January 1998-December 2002). Diagnostic evaluation and Axis I comorbidities were collected by means of the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Personality status was assessed by using the Structured Clinical Interview for DSM-IV Axis II Disorders (SCID-II). Socio-demographic and clinical features (including Axis II comorbidities) were compared between OCD patients with and without a lifetime comorbidity of BD.

RESULTS

A total of 21 patients with OCD (10.3%) met DSM-IV criteria for a lifetime BD diagnosis: 4 (2.0%) with BD type I and 17 (8.3%) with BD type II. Those without a BD diagnosis showed significantly higher rates of male gender, sexual and hoarding obsessions, repeating compulsions and lifetime comorbid substance use disorders, when compared with patients with BD/OCD. With regard to personality disorders, those with BD/OCD showed higher prevalence rates of Cluster A (42.9% versus 21.3%; p=0.027) and Cluster B (57.1% versus 29.0%; p=0.009) personality disorders. Narcissistic and antisocial personality disorders were more frequent in BD/OCD.

CONCLUSIONS

Our results point towards clinically relevant effects of comorbid BD on the personality profiles of OCD patients, with higher rates of narcissistic and antisocial personality disorders in BD/OCD patients.

Authors+Show Affiliations

Department of Neuroscience, Anxiety and Mood Disorders Unit, University of Turin, Turin, Italy. giuseppemaina@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17988362

Citation

Maina, Giuseppe, et al. "Bipolar Obsessive-compulsive Disorder and Personality Disorders." Bipolar Disorders, vol. 9, no. 7, 2007, pp. 722-9.
Maina G, Albert U, Pessina E, et al. Bipolar obsessive-compulsive disorder and personality disorders. Bipolar Disord. 2007;9(7):722-9.
Maina, G., Albert, U., Pessina, E., & Bogetto, F. (2007). Bipolar obsessive-compulsive disorder and personality disorders. Bipolar Disorders, 9(7), 722-9.
Maina G, et al. Bipolar Obsessive-compulsive Disorder and Personality Disorders. Bipolar Disord. 2007;9(7):722-9. PubMed PMID: 17988362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bipolar obsessive-compulsive disorder and personality disorders. AU - Maina,Giuseppe, AU - Albert,Umberto, AU - Pessina,Enrico, AU - Bogetto,Filippo, PY - 2007/11/9/pubmed PY - 2008/1/26/medline PY - 2007/11/9/entrez SP - 722 EP - 9 JF - Bipolar disorders JO - Bipolar Disord VL - 9 IS - 7 N2 - OBJECTIVES: Relatively few systematic data exist on the clinical impact of bipolar comorbidity in obsessive-compulsive disorder (OCD) and no studies have investigated the influence of such a comorbidity on the prevalence and pattern of Axis II comorbidity. The aim of the present study was to explore the comorbidity of personality disorders in a group of patients with OCD and comorbid bipolar disorder (BD). METHODS: The sample consisted of 204 subjects with a principal diagnosis of OCD (DSM-IV) and a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score>or=16 recruited from all patients consecutively referred to the Anxiety and Mood Disorders Unit, Department of Neuroscience, University of Turin over a period of 5 years (January 1998-December 2002). Diagnostic evaluation and Axis I comorbidities were collected by means of the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Personality status was assessed by using the Structured Clinical Interview for DSM-IV Axis II Disorders (SCID-II). Socio-demographic and clinical features (including Axis II comorbidities) were compared between OCD patients with and without a lifetime comorbidity of BD. RESULTS: A total of 21 patients with OCD (10.3%) met DSM-IV criteria for a lifetime BD diagnosis: 4 (2.0%) with BD type I and 17 (8.3%) with BD type II. Those without a BD diagnosis showed significantly higher rates of male gender, sexual and hoarding obsessions, repeating compulsions and lifetime comorbid substance use disorders, when compared with patients with BD/OCD. With regard to personality disorders, those with BD/OCD showed higher prevalence rates of Cluster A (42.9% versus 21.3%; p=0.027) and Cluster B (57.1% versus 29.0%; p=0.009) personality disorders. Narcissistic and antisocial personality disorders were more frequent in BD/OCD. CONCLUSIONS: Our results point towards clinically relevant effects of comorbid BD on the personality profiles of OCD patients, with higher rates of narcissistic and antisocial personality disorders in BD/OCD patients. SN - 1398-5647 UR - https://www.unboundmedicine.com/medline/citation/17988362/Bipolar_obsessive_compulsive_disorder_and_personality_disorders_ L2 - https://doi.org/10.1111/j.1399-5618.2007.00508.x DB - PRIME DP - Unbound Medicine ER -