Tags

Type your tag names separated by a space and hit enter

[Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients].
Zhonghua Jie He He Hu Xi Za Zhi. 2007 Aug; 30(8):573-6.ZJ

Abstract

OBJECTIVE

To investigate the expressions of and the effect of smoking on vascular endothelial growth factor (VEGF) and induced nitric oxide synthase (iNOS) in lung tissues of chronic obstructive pulmonary disease (COPD) patients.

METHODS

The peripheral lung tissues were obtained from 46 patients with lung carcinoma. They were divided into three groups according to their habit of smoking and lung function, 19 smokers with moderate COPD, 12 smokers and 15 nonsmokers with normal lung function. The expression of VEGF and iNOS was detected by immunohistochemistry.

RESULTS

Expressions of VEGF and iNOS were increased in lung tissues of smokers without COPD (1.50 +/- 0.39, 1.45 +/- 0.41) compared with nonsmokers without COPD (1.18 +/- 0.33, 1.09 +/- 0.41) (each P < 0.05), and were significantly increased in lung tissues of smokers with moderate COPD (2.19 +/- 0.51, 2.39 +/- 0.45) compared with nonsmokers without COPD (each P < 0.01). The expression of VEGF in lung tissues was significantly correlated with the expression of iNOS (r = 0.78, P < 0.01), but was inversely correlated with FEV(1) (r = -0.67, P < 0.01).

CONCLUSIONS

Expressions of VEGF and iNOS were upregulated in lung tissues of smokers and patients with moderate COPD. Overexpression of iNOS and VEGF may participate in the mechanism of airway and vascular remodeling, and airflow limitation in COPD.

Authors+Show Affiliations

Department of Respiratory Medicine, The First Clinical College of Harbin Medical University, Harbin 150001, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17988548

Citation

Huo, Jian-min, et al. "[Expressions of and the Effect of Smoking On Vascular Endothelial Growth Factor and Induced Nitric Oxide Synthase in Lung Tissues of Chronic Obstructive Pulmonary Disease Patients]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 30, no. 8, 2007, pp. 573-6.
Huo JM, Chen JY, Kong YJ, et al. [Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients]. Zhonghua Jie He He Hu Xi Za Zhi. 2007;30(8):573-6.
Huo, J. M., Chen, J. Y., Kong, Y. J., & Shi, Y. Z. (2007). [Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 30(8), 573-6.
Huo JM, et al. [Expressions of and the Effect of Smoking On Vascular Endothelial Growth Factor and Induced Nitric Oxide Synthase in Lung Tissues of Chronic Obstructive Pulmonary Disease Patients]. Zhonghua Jie He He Hu Xi Za Zhi. 2007;30(8):573-6. PubMed PMID: 17988548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients]. AU - Huo,Jian-min, AU - Chen,Jing-ying, AU - Kong,Ying-jun, AU - Shi,Yu-zhi, PY - 2007/11/9/pubmed PY - 2009/3/20/medline PY - 2007/11/9/entrez SP - 573 EP - 6 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 30 IS - 8 N2 - OBJECTIVE: To investigate the expressions of and the effect of smoking on vascular endothelial growth factor (VEGF) and induced nitric oxide synthase (iNOS) in lung tissues of chronic obstructive pulmonary disease (COPD) patients. METHODS: The peripheral lung tissues were obtained from 46 patients with lung carcinoma. They were divided into three groups according to their habit of smoking and lung function, 19 smokers with moderate COPD, 12 smokers and 15 nonsmokers with normal lung function. The expression of VEGF and iNOS was detected by immunohistochemistry. RESULTS: Expressions of VEGF and iNOS were increased in lung tissues of smokers without COPD (1.50 +/- 0.39, 1.45 +/- 0.41) compared with nonsmokers without COPD (1.18 +/- 0.33, 1.09 +/- 0.41) (each P < 0.05), and were significantly increased in lung tissues of smokers with moderate COPD (2.19 +/- 0.51, 2.39 +/- 0.45) compared with nonsmokers without COPD (each P < 0.01). The expression of VEGF in lung tissues was significantly correlated with the expression of iNOS (r = 0.78, P < 0.01), but was inversely correlated with FEV(1) (r = -0.67, P < 0.01). CONCLUSIONS: Expressions of VEGF and iNOS were upregulated in lung tissues of smokers and patients with moderate COPD. Overexpression of iNOS and VEGF may participate in the mechanism of airway and vascular remodeling, and airflow limitation in COPD. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/17988548/[Expressions_of_and_the_effect_of_smoking_on_vascular_endothelial_growth_factor_and_induced_nitric_oxide_synthase_in_lung_tissues_of_chronic_obstructive_pulmonary_disease_patients]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1001-0939&amp;year=2007&amp;vol=30&amp;issue=8&amp;fpage=573 DB - PRIME DP - Unbound Medicine ER -