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Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypes.

Abstract

Because little is known about the etiology of non-Hodgkin lymphoma (NHL), a heterogeneous disease, and because dietary factors are modifiable, the authors examined the associations between nutrients related to one-carbon metabolism and risk of NHL in a population-based case-control study of Connecticut women diagnosed between 1996 and 2000. A total of 594 cases and 710 controls completed a food frequency questionnaire for determination of intakes of folate, vitamins B(2), B(6), and B(12), and methionine. Through unconditional logistic regression, the authors estimated the risk of NHL associated with intake of each nutrient. Comparing the highest quartile of intake with the lowest, the authors found lower risks of all NHL associated with increasing intakes of folate and methionine. Analysis by NHL subtype indicated lower risks of diffuse large B-cell lymphoma (highest quartile vs. lowest: odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.30, 0.98; p-trend = 0.02) and marginal zone lymphoma (highest quartile vs. lowest: OR = 0.08, 95% CI: 0.02, 0.26; p-trend < 0.0001) associated with folate. Vitamin B(6) intake was also associated with lower risk of NHL overall and of marginal zone lymphoma (highest quartile vs. lowest: OR = 0.23, 95% CI: 0.08, 0.65; p-trend = 0.002). These findings suggest that these nutrients may be important for susceptibility to NHL.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 20852, USA. koutross@mail.nih.gov

    , , , , , , ,

    Source

    American journal of epidemiology 167:3 2008 Feb 01 pg 287-94

    MeSH

    Carbon
    Case-Control Studies
    Diet
    Diet Surveys
    Female
    Folic Acid
    Humans
    Logistic Models
    Lymphoma, Non-Hodgkin
    Methionine
    Middle Aged
    Multivariate Analysis
    Riboflavin
    Risk Factors
    Vitamin B 6
    Vitamin B Complex
    Vitamin B Deficiency

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17989056

    Citation

    Koutros, Stella, et al. "Nutrients Contributing to One-carbon Metabolism and Risk of non-Hodgkin Lymphoma Subtypes." American Journal of Epidemiology, vol. 167, no. 3, 2008, pp. 287-94.
    Koutros S, Zhang Y, Zhu Y, et al. Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypes. Am J Epidemiol. 2008;167(3):287-94.
    Koutros, S., Zhang, Y., Zhu, Y., Mayne, S. T., Zahm, S. H., Holford, T. R., ... Zheng, T. (2008). Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypes. American Journal of Epidemiology, 167(3), pp. 287-94.
    Koutros S, et al. Nutrients Contributing to One-carbon Metabolism and Risk of non-Hodgkin Lymphoma Subtypes. Am J Epidemiol. 2008 Feb 1;167(3):287-94. PubMed PMID: 17989056.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypes. AU - Koutros,Stella, AU - Zhang,Yawei, AU - Zhu,Yong, AU - Mayne,Susan T, AU - Zahm,Sheila Hoar, AU - Holford,Theodore R, AU - Leaderer,Brian P, AU - Boyle,Peter, AU - Zheng,Tongzhang, Y1 - 2007/11/06/ PY - 2007/11/9/pubmed PY - 2008/2/7/medline PY - 2007/11/9/entrez SP - 287 EP - 94 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 167 IS - 3 N2 - Because little is known about the etiology of non-Hodgkin lymphoma (NHL), a heterogeneous disease, and because dietary factors are modifiable, the authors examined the associations between nutrients related to one-carbon metabolism and risk of NHL in a population-based case-control study of Connecticut women diagnosed between 1996 and 2000. A total of 594 cases and 710 controls completed a food frequency questionnaire for determination of intakes of folate, vitamins B(2), B(6), and B(12), and methionine. Through unconditional logistic regression, the authors estimated the risk of NHL associated with intake of each nutrient. Comparing the highest quartile of intake with the lowest, the authors found lower risks of all NHL associated with increasing intakes of folate and methionine. Analysis by NHL subtype indicated lower risks of diffuse large B-cell lymphoma (highest quartile vs. lowest: odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.30, 0.98; p-trend = 0.02) and marginal zone lymphoma (highest quartile vs. lowest: OR = 0.08, 95% CI: 0.02, 0.26; p-trend < 0.0001) associated with folate. Vitamin B(6) intake was also associated with lower risk of NHL overall and of marginal zone lymphoma (highest quartile vs. lowest: OR = 0.23, 95% CI: 0.08, 0.65; p-trend = 0.002). These findings suggest that these nutrients may be important for susceptibility to NHL. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/17989056/Nutrients_contributing_to_one_carbon_metabolism_and_risk_of_non_Hodgkin_lymphoma_subtypes_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm307 DB - PRIME DP - Unbound Medicine ER -