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Glucose indices, health behaviors, and incidence of diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study.
Diabetes Care 2008; 31(2):267-72DC

Abstract

OBJECTIVE

This national, population-based study reports diabetes incidence based on oral glucose tolerance tests (OGTTs) and identifies risk factors for diabetes in Australians.

RESEARCH DESIGN AND METHODS

The Australian Diabetes, Obesity and Lifestyle Study followed-up 5,842 participants over 5 years. Normal glycemia, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes were defined using World Health Organization criteria.

RESULTS

Age-standardized annual incidence of diabetes for men and women was 0.8% (95% CI 0.6-0.9) and 0.7% (0.5-0.8), respectively. The annual incidence was 0.2% (0.2-0.3), 2.6% (1.8-3.4), and 3.5% (2.9-4.2) among those with normal glycemia, IFG, and IGT, respectively, at baseline. Among those with IFG, the incidence was significantly higher in women (4.0 vs. 2.0%), while among those with IGT, it was significantly higher in men (4.4 vs. 2.9%). Using multivariate logistic regression, hypertension (odds ratio 1.64 [95% CI 1.17-2.28]), hypertriglyceridemia (1.46 [1.05-2.02]), log fasting plasma glucose (odds ratio per 1 SD 5.25 [95% CI 3.98-6.92]), waist circumference (1.26 [1.08-1.48]), smoking (1.70 [96% CI 1.11-2.63]), physical inactivity (1.56 [1.12-2.16]), family history of diabetes (1.82 [1.30-2.52]), and low education level (1.85 [1.04-3.31]) were associated with incident diabetes. In age- and sex-adjusted models, A1C was a predictor of diabetes in the whole population, in those with normal glycemia, and in those with IGT or IFG.

CONCLUSIONS

Diabetes incidence is 10-20 times greater in those with IGT or IFG than those with normal glycemia. Measures of glycemia, A1C, metabolic syndrome components, education level, smoking, and physical inactivity are risk factors for diabetes.

Authors+Show Affiliations

International Diabetes Institute, 250 Kooyong Rd., Caulfield, Victoria, 3162, Australia. dmagliano@idi.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17989310

Citation

Magliano, Dianna J., et al. "Glucose Indices, Health Behaviors, and Incidence of Diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study." Diabetes Care, vol. 31, no. 2, 2008, pp. 267-72.
Magliano DJ, Barr EL, Zimmet PZ, et al. Glucose indices, health behaviors, and incidence of diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care. 2008;31(2):267-72.
Magliano, D. J., Barr, E. L., Zimmet, P. Z., Cameron, A. J., Dunstan, D. W., Colagiuri, S., ... Shaw, J. E. (2008). Glucose indices, health behaviors, and incidence of diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care, 31(2), pp. 267-72.
Magliano DJ, et al. Glucose Indices, Health Behaviors, and Incidence of Diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care. 2008;31(2):267-72. PubMed PMID: 17989310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucose indices, health behaviors, and incidence of diabetes in Australia: the Australian Diabetes, Obesity and Lifestyle Study. AU - Magliano,Dianna J, AU - Barr,Elizabeth L M, AU - Zimmet,Paul Z, AU - Cameron,Adrian J, AU - Dunstan,David W, AU - Colagiuri,Stephen, AU - Jolley,Damien, AU - Owen,Neville, AU - Phillips,Patrick, AU - Tapp,Robyn J, AU - Welborn,Tim A, AU - Shaw,Jonathan E, Y1 - 2007/11/05/ PY - 2007/11/9/pubmed PY - 2008/3/8/medline PY - 2007/11/9/entrez SP - 267 EP - 72 JF - Diabetes care JO - Diabetes Care VL - 31 IS - 2 N2 - OBJECTIVE: This national, population-based study reports diabetes incidence based on oral glucose tolerance tests (OGTTs) and identifies risk factors for diabetes in Australians. RESEARCH DESIGN AND METHODS: The Australian Diabetes, Obesity and Lifestyle Study followed-up 5,842 participants over 5 years. Normal glycemia, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes were defined using World Health Organization criteria. RESULTS: Age-standardized annual incidence of diabetes for men and women was 0.8% (95% CI 0.6-0.9) and 0.7% (0.5-0.8), respectively. The annual incidence was 0.2% (0.2-0.3), 2.6% (1.8-3.4), and 3.5% (2.9-4.2) among those with normal glycemia, IFG, and IGT, respectively, at baseline. Among those with IFG, the incidence was significantly higher in women (4.0 vs. 2.0%), while among those with IGT, it was significantly higher in men (4.4 vs. 2.9%). Using multivariate logistic regression, hypertension (odds ratio 1.64 [95% CI 1.17-2.28]), hypertriglyceridemia (1.46 [1.05-2.02]), log fasting plasma glucose (odds ratio per 1 SD 5.25 [95% CI 3.98-6.92]), waist circumference (1.26 [1.08-1.48]), smoking (1.70 [96% CI 1.11-2.63]), physical inactivity (1.56 [1.12-2.16]), family history of diabetes (1.82 [1.30-2.52]), and low education level (1.85 [1.04-3.31]) were associated with incident diabetes. In age- and sex-adjusted models, A1C was a predictor of diabetes in the whole population, in those with normal glycemia, and in those with IGT or IFG. CONCLUSIONS: Diabetes incidence is 10-20 times greater in those with IGT or IFG than those with normal glycemia. Measures of glycemia, A1C, metabolic syndrome components, education level, smoking, and physical inactivity are risk factors for diabetes. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17989310/Glucose_indices_health_behaviors_and_incidence_of_diabetes_in_Australia:_the_Australian_Diabetes_Obesity_and_Lifestyle_Study_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=17989310 DB - PRIME DP - Unbound Medicine ER -