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Closed-loop feedback computer-controlled infusion of phenylephrine for maintaining blood pressure during spinal anaesthesia for caesarean section: a preliminary descriptive study.
Anaesthesia. 2007 Dec; 62(12):1251-6.A

Abstract

We describe the novel use of a closed-loop feedback computer-controlled infusion of phenylephrine for maintaining blood pressure in 53 patients having spinal anaesthesia for elective caesarean section. A simple on-off algorithm was used that activated an intravenous phenylephrine infusion at 100 microg.min(-1) when systolic blood pressure was less than or equal to baseline and stopped the infusion when systolic blood pressure exceeded baseline. Up to uterine incision, 94.6% of all systolic blood pressure measurements were within the range (baseline +/- 20%). Seven patients (13.2%) had one or more episodes of hypotension (systolic blood pressure < 80% of baseline) and 23 patients (37.7%) had one or more episodes of hypertension (systolic blood pressure > 120% of baseline). No patient had nausea or vomiting and in no case was umbilical arterial blood pH < 7.2. Calculated system performance parameters were comparable with those of previously published closed-loop systems and provide a reference for the potential development and comparison of more advanced algorithms.

Authors+Show Affiliations

Department of Anaesthesia and Intensive Care, The Chinese Unviersity of Hong Kong, Prince of Wales Hospital, HShatin, Hong Kong, China. warwick@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17991262

Citation

Ngan Kee, W D., et al. "Closed-loop Feedback Computer-controlled Infusion of Phenylephrine for Maintaining Blood Pressure During Spinal Anaesthesia for Caesarean Section: a Preliminary Descriptive Study." Anaesthesia, vol. 62, no. 12, 2007, pp. 1251-6.
Ngan Kee WD, Tam YH, Khaw KS, et al. Closed-loop feedback computer-controlled infusion of phenylephrine for maintaining blood pressure during spinal anaesthesia for caesarean section: a preliminary descriptive study. Anaesthesia. 2007;62(12):1251-6.
Ngan Kee, W. D., Tam, Y. H., Khaw, K. S., Ng, F. F., Critchley, L. A., & Karmakar, M. K. (2007). Closed-loop feedback computer-controlled infusion of phenylephrine for maintaining blood pressure during spinal anaesthesia for caesarean section: a preliminary descriptive study. Anaesthesia, 62(12), 1251-6.
Ngan Kee WD, et al. Closed-loop Feedback Computer-controlled Infusion of Phenylephrine for Maintaining Blood Pressure During Spinal Anaesthesia for Caesarean Section: a Preliminary Descriptive Study. Anaesthesia. 2007;62(12):1251-6. PubMed PMID: 17991262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Closed-loop feedback computer-controlled infusion of phenylephrine for maintaining blood pressure during spinal anaesthesia for caesarean section: a preliminary descriptive study. AU - Ngan Kee,W D, AU - Tam,Y H, AU - Khaw,K S, AU - Ng,F F, AU - Critchley,L A, AU - Karmakar,M K, PY - 2007/11/10/pubmed PY - 2007/12/7/medline PY - 2007/11/10/entrez SP - 1251 EP - 6 JF - Anaesthesia JO - Anaesthesia VL - 62 IS - 12 N2 - We describe the novel use of a closed-loop feedback computer-controlled infusion of phenylephrine for maintaining blood pressure in 53 patients having spinal anaesthesia for elective caesarean section. A simple on-off algorithm was used that activated an intravenous phenylephrine infusion at 100 microg.min(-1) when systolic blood pressure was less than or equal to baseline and stopped the infusion when systolic blood pressure exceeded baseline. Up to uterine incision, 94.6% of all systolic blood pressure measurements were within the range (baseline +/- 20%). Seven patients (13.2%) had one or more episodes of hypotension (systolic blood pressure < 80% of baseline) and 23 patients (37.7%) had one or more episodes of hypertension (systolic blood pressure > 120% of baseline). No patient had nausea or vomiting and in no case was umbilical arterial blood pH < 7.2. Calculated system performance parameters were comparable with those of previously published closed-loop systems and provide a reference for the potential development and comparison of more advanced algorithms. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/17991262/Closed_loop_feedback_computer_controlled_infusion_of_phenylephrine_for_maintaining_blood_pressure_during_spinal_anaesthesia_for_caesarean_section:_a_preliminary_descriptive_study_ L2 - https://doi.org/10.1111/j.1365-2044.2007.05257.x DB - PRIME DP - Unbound Medicine ER -