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Correlation of immunophenotype of sinonasal non-Hodgkin's lymphoma to Epstein-Barr virus infection.
Ai Zheng. 2007 Nov; 26(11):1170-6.AZ

Abstract

BACKGROUND & OBJECTIVE

There are differences in the prevalence rate and composition of immunophenotypes of sinonasal non-Hodgkin's lymphoma (NHL) depending on the geography. This study was to investigate the immunophenotypes of sinonasal NHLs and their relationship to Epstein-Barr virus (EBV) infection in Guangzhou, China.

METHODS

Fifty-seven NHL samples of the sinonasal region were collected from the Department of Pathology, Cancer Center of Sun Yat-sen University from Apr. 1, 2000 to Oct. 31, 2006. HE staining and immunohistochemical staining were performed. Both Epstein-Barr virus-encoded small RNA (EBER) hybridization and PCR were applied to identify EBV infection.

RESULTS

Seventy-one sinonasal NHLs were found in all 1 412 NHLs (71/1 412, 5.03%). Only 57 out of the 71 NHL biopsy tissues were suitable for this study. The median age of the patients was 50 years (ranged from 3 to 75 years). There were 38 males and 19 females. Forty-four sinonasal NHLs (44/57, 77.19%) were NK/T-cell lymphoma, nasal type, all of which were infected with EBV. Among them, 37 patients (84.09%) appeared to be NK-cell neoplasm (EBV+/CD56+), and 7 cases (15.91%) showed an EBV+/CD56-cytotoxic T-cell phenotype. Eleven cases (11/57, 19.30%) were B-cell lymphoma. There were 6 cases of diffuse large B-cell immunophenotype, 2 cases of Burkitt (Burkitt-like) lymphoma (EBV+), 1 case of extramedullary plasmacytoma (EBV+), 1 case of MALT-lymphoma (EBV-), and 1 case of small lymphocytic lymphoma (EBV-). Only 2 cases (2/57, 3.51%; EBV-) were peripheral T-cell lymphoma, unspecified. The del-LMP1 EBV strain harbored in 25 out of 37 available DNA samples of NK/T-cell lymphoma (25/37, 67.57%); and the wt-LMP1 EBV strain was found in 12 samples (12/37, 32.43%).

CONCLUSION

The most common sinonasal NHL is the NK/T-cell lymphoma, nasal type, which can be further subclassified into NK-cell neoplasm (EBV+/CD56+) and EBV+/CD56-cytotoxic T-cell phenotype. The major EBV strain in NK/T-cell lymphomas is del-LMP1 strain.

Authors+Show Affiliations

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17991313

Citation

Feng, Yan-Fen, et al. "Correlation of Immunophenotype of Sinonasal non-Hodgkin's Lymphoma to Epstein-Barr Virus Infection." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 26, no. 11, 2007, pp. 1170-6.
Feng YF, Wu QL, Zong YS. Correlation of immunophenotype of sinonasal non-Hodgkin's lymphoma to Epstein-Barr virus infection. Ai Zheng. 2007;26(11):1170-6.
Feng, Y. F., Wu, Q. L., & Zong, Y. S. (2007). Correlation of immunophenotype of sinonasal non-Hodgkin's lymphoma to Epstein-Barr virus infection. Ai Zheng = Aizheng = Chinese Journal of Cancer, 26(11), 1170-6.
Feng YF, Wu QL, Zong YS. Correlation of Immunophenotype of Sinonasal non-Hodgkin's Lymphoma to Epstein-Barr Virus Infection. Ai Zheng. 2007;26(11):1170-6. PubMed PMID: 17991313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of immunophenotype of sinonasal non-Hodgkin's lymphoma to Epstein-Barr virus infection. AU - Feng,Yan-Fen, AU - Wu,Qiu-Liang, AU - Zong,Yong-Sheng, PY - 2007/11/10/pubmed PY - 2009/12/24/medline PY - 2007/11/10/entrez SP - 1170 EP - 6 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 26 IS - 11 N2 - BACKGROUND & OBJECTIVE: There are differences in the prevalence rate and composition of immunophenotypes of sinonasal non-Hodgkin's lymphoma (NHL) depending on the geography. This study was to investigate the immunophenotypes of sinonasal NHLs and their relationship to Epstein-Barr virus (EBV) infection in Guangzhou, China. METHODS: Fifty-seven NHL samples of the sinonasal region were collected from the Department of Pathology, Cancer Center of Sun Yat-sen University from Apr. 1, 2000 to Oct. 31, 2006. HE staining and immunohistochemical staining were performed. Both Epstein-Barr virus-encoded small RNA (EBER) hybridization and PCR were applied to identify EBV infection. RESULTS: Seventy-one sinonasal NHLs were found in all 1 412 NHLs (71/1 412, 5.03%). Only 57 out of the 71 NHL biopsy tissues were suitable for this study. The median age of the patients was 50 years (ranged from 3 to 75 years). There were 38 males and 19 females. Forty-four sinonasal NHLs (44/57, 77.19%) were NK/T-cell lymphoma, nasal type, all of which were infected with EBV. Among them, 37 patients (84.09%) appeared to be NK-cell neoplasm (EBV+/CD56+), and 7 cases (15.91%) showed an EBV+/CD56-cytotoxic T-cell phenotype. Eleven cases (11/57, 19.30%) were B-cell lymphoma. There were 6 cases of diffuse large B-cell immunophenotype, 2 cases of Burkitt (Burkitt-like) lymphoma (EBV+), 1 case of extramedullary plasmacytoma (EBV+), 1 case of MALT-lymphoma (EBV-), and 1 case of small lymphocytic lymphoma (EBV-). Only 2 cases (2/57, 3.51%; EBV-) were peripheral T-cell lymphoma, unspecified. The del-LMP1 EBV strain harbored in 25 out of 37 available DNA samples of NK/T-cell lymphoma (25/37, 67.57%); and the wt-LMP1 EBV strain was found in 12 samples (12/37, 32.43%). CONCLUSION: The most common sinonasal NHL is the NK/T-cell lymphoma, nasal type, which can be further subclassified into NK-cell neoplasm (EBV+/CD56+) and EBV+/CD56-cytotoxic T-cell phenotype. The major EBV strain in NK/T-cell lymphomas is del-LMP1 strain. UR - https://www.unboundmedicine.com/medline/citation/17991313/Correlation_of_immunophenotype_of_sinonasal_non_Hodgkin's_lymphoma_to_Epstein_Barr_virus_infection_ DB - PRIME DP - Unbound Medicine ER -