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High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism.
Psychosom Med 2007; 69(9):932-4PM

Abstract

OBJECTIVE

To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults.

METHODS

A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory--Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool).

RESULTS

Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of >or=10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements.

CONCLUSIONS

In conjunction with other reports, these findings suggest that the omega-3 and omega-6 fatty acids are related to negative affect at both the symptom and trait levels.

Authors+Show Affiliations

Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335-3902, USA. Sarah.Conklin@allegheny.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17991818

Citation

Conklin, Sarah M., et al. "High Omega-6 and Low Omega-3 Fatty Acids Are Associated With Depressive Symptoms and Neuroticism." Psychosomatic Medicine, vol. 69, no. 9, 2007, pp. 932-4.
Conklin SM, Manuck SB, Yao JK, et al. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom Med. 2007;69(9):932-4.
Conklin, S. M., Manuck, S. B., Yao, J. K., Flory, J. D., Hibbeln, J. R., & Muldoon, M. F. (2007). High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosomatic Medicine, 69(9), pp. 932-4.
Conklin SM, et al. High Omega-6 and Low Omega-3 Fatty Acids Are Associated With Depressive Symptoms and Neuroticism. Psychosom Med. 2007;69(9):932-4. PubMed PMID: 17991818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. AU - Conklin,Sarah M, AU - Manuck,Stephen B, AU - Yao,Jeffrey K, AU - Flory,Janine D, AU - Hibbeln,Joseph R, AU - Muldoon,Matthew F, Y1 - 2007/11/08/ PY - 2007/11/10/pubmed PY - 2007/12/18/medline PY - 2007/11/10/entrez SP - 932 EP - 4 JF - Psychosomatic medicine JO - Psychosom Med VL - 69 IS - 9 N2 - OBJECTIVE: To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. METHODS: A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory--Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool). RESULTS: Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of >or=10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements. CONCLUSIONS: In conjunction with other reports, these findings suggest that the omega-3 and omega-6 fatty acids are related to negative affect at both the symptom and trait levels. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/17991818/High_omega_6_and_low_omega_3_fatty_acids_are_associated_with_depressive_symptoms_and_neuroticism_ L2 - http://Insights.ovid.com/pubmed?pmid=17991818 DB - PRIME DP - Unbound Medicine ER -