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High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism.
Psychosom Med. 2007 Dec; 69(9):932-4.PM

Abstract

OBJECTIVE

To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults.

METHODS

A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory--Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool).

RESULTS

Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of >or=10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements.

CONCLUSIONS

In conjunction with other reports, these findings suggest that the omega-3 and omega-6 fatty acids are related to negative affect at both the symptom and trait levels.

Authors+Show Affiliations

Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335-3902, USA. Sarah.Conklin@allegheny.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17991818

Citation

Conklin, Sarah M., et al. "High Omega-6 and Low Omega-3 Fatty Acids Are Associated With Depressive Symptoms and Neuroticism." Psychosomatic Medicine, vol. 69, no. 9, 2007, pp. 932-4.
Conklin SM, Manuck SB, Yao JK, et al. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom Med. 2007;69(9):932-4.
Conklin, S. M., Manuck, S. B., Yao, J. K., Flory, J. D., Hibbeln, J. R., & Muldoon, M. F. (2007). High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosomatic Medicine, 69(9), 932-4.
Conklin SM, et al. High Omega-6 and Low Omega-3 Fatty Acids Are Associated With Depressive Symptoms and Neuroticism. Psychosom Med. 2007;69(9):932-4. PubMed PMID: 17991818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. AU - Conklin,Sarah M, AU - Manuck,Stephen B, AU - Yao,Jeffrey K, AU - Flory,Janine D, AU - Hibbeln,Joseph R, AU - Muldoon,Matthew F, Y1 - 2007/11/08/ PY - 2007/11/10/pubmed PY - 2007/12/18/medline PY - 2007/11/10/entrez SP - 932 EP - 4 JF - Psychosomatic medicine JO - Psychosom Med VL - 69 IS - 9 N2 - OBJECTIVE: To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. METHODS: A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory--Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool). RESULTS: Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of >or=10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements. CONCLUSIONS: In conjunction with other reports, these findings suggest that the omega-3 and omega-6 fatty acids are related to negative affect at both the symptom and trait levels. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/17991818/High_omega_6_and_low_omega_3_fatty_acids_are_associated_with_depressive_symptoms_and_neuroticism_ L2 - http://dx.doi.org/10.1097/PSY.0b013e31815aaa42 DB - PRIME DP - Unbound Medicine ER -