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Reactive oxygen species in melanoma and its therapeutic implications.
Melanoma Res. 2007 Dec; 17(6):400-9.MR

Abstract

Oxidative phosphorylation in the mitochondria is an important energy-producing process for eukaryotic cells, but this process can also result in producing potentially cell-damaging side products. Oxygen is the final proton acceptor in this cascade of electron/proton transfer and results in harmless water. The electron transfer, however, is not completely efficient and results in the production of reactive oxygen species (ROS). Low amounts of these ROS are important for cellular-signalling pathways. Excessive ROS, however, can induce cell damage that can culminate in cell death. Therefore, the cell has developed an antioxidant network to scavenge excessively produced ROS. In general, the balance between the production and scavenging of ROS leads to homeostasis. Disturbance of this equilibrium can alter normal cellular processes; it often occurs in tumour cells. In this review, the role of ROS in cutaneous melanoma development and progression is described. Cutaneous melanoma arises from epidermal melanocytes in skin, which is a relatively hypoxic tissue. ROS are generated as a result of increased metabolism of transformed cells, immune reaction against the developing tumour, ultraviolet radiation, melanin production and an altered antioxidant system. Knowledge of the role of ROS in melanoma development and the mechanisms that alleviate oxidative stress can aid in the development of better antimelanoma therapies.

Authors+Show Affiliations

Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17992124

Citation

Wittgen, Hanneke G M., and Léon C L T. van Kempen. "Reactive Oxygen Species in Melanoma and Its Therapeutic Implications." Melanoma Research, vol. 17, no. 6, 2007, pp. 400-9.
Wittgen HG, van Kempen LC. Reactive oxygen species in melanoma and its therapeutic implications. Melanoma Res. 2007;17(6):400-9.
Wittgen, H. G., & van Kempen, L. C. (2007). Reactive oxygen species in melanoma and its therapeutic implications. Melanoma Research, 17(6), 400-9.
Wittgen HG, van Kempen LC. Reactive Oxygen Species in Melanoma and Its Therapeutic Implications. Melanoma Res. 2007;17(6):400-9. PubMed PMID: 17992124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactive oxygen species in melanoma and its therapeutic implications. AU - Wittgen,Hanneke G M, AU - van Kempen,Léon C L T, PY - 2007/11/10/pubmed PY - 2008/2/15/medline PY - 2007/11/10/entrez SP - 400 EP - 9 JF - Melanoma research JO - Melanoma Res VL - 17 IS - 6 N2 - Oxidative phosphorylation in the mitochondria is an important energy-producing process for eukaryotic cells, but this process can also result in producing potentially cell-damaging side products. Oxygen is the final proton acceptor in this cascade of electron/proton transfer and results in harmless water. The electron transfer, however, is not completely efficient and results in the production of reactive oxygen species (ROS). Low amounts of these ROS are important for cellular-signalling pathways. Excessive ROS, however, can induce cell damage that can culminate in cell death. Therefore, the cell has developed an antioxidant network to scavenge excessively produced ROS. In general, the balance between the production and scavenging of ROS leads to homeostasis. Disturbance of this equilibrium can alter normal cellular processes; it often occurs in tumour cells. In this review, the role of ROS in cutaneous melanoma development and progression is described. Cutaneous melanoma arises from epidermal melanocytes in skin, which is a relatively hypoxic tissue. ROS are generated as a result of increased metabolism of transformed cells, immune reaction against the developing tumour, ultraviolet radiation, melanin production and an altered antioxidant system. Knowledge of the role of ROS in melanoma development and the mechanisms that alleviate oxidative stress can aid in the development of better antimelanoma therapies. SN - 0960-8931 UR - https://www.unboundmedicine.com/medline/citation/17992124/Reactive_oxygen_species_in_melanoma_and_its_therapeutic_implications_ DB - PRIME DP - Unbound Medicine ER -