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Dietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada).

Abstract

OBJECTIVE

To evaluate whether phytoestrogen intake is associated with reduced breast cancer risk, using a novel phytoestrogen database.

METHODS

Population-based breast cancer cases aged 25-74 years (diagnosed 2002-2003) were identified using Ontario Cancer Registry (n = 3,063) and controls (n = 3,430) were an age-stratified random sample of women identified through random digit dialing. An epidemiologic and Block food frequency questionnaire--expanded to include phytoestrogen-containing foods--was mailed to all subjects. The recently published Ontario phytoestrogen database was applied to FFQ responses to estimate intake. Multivariate logistic regression provided odds ratio (OR) estimates, while controlling for confounders.

RESULTS

Among all women, lignan intake was associated with a reduced breast cancer risk (Q5 vs. Q1 MVOR: 0.81, 95% CI: 0.65, 0.99); however, following stratification by BMI, this reduction in risk was statistically significant only among overweight (BMI > 25) women. Total phytoestrogen intake was also associated with a risk reduction among overweight women only. Among pre-menopausal women, total phytoestrogen intake was associated with a significant reduction in breast cancer risk among overweight women only (Q5 vs. Q1 MVOR: 0.51, 95% CI: 0.30, 0.87). Among post-menopausal women, no statistically significant association was observed between breast cancer risk and isoflavones or lignans.

CONCLUSION

Lignan intake may be associated with reduced breast cancer risk among pre-menopausal women, and our data suggest BMI modifies this association.

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  • Authors+Show Affiliations

    ,

    Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada. michelle.cotterchio@cancercare.on.ca

    , , ,

    Source

    Cancer causes & control : CCC 19:3 2008 Apr pg 259-72

    MeSH

    Adult
    Aged
    Body Mass Index
    Breast Neoplasms
    Canada
    Case-Control Studies
    Diet
    Diet Surveys
    Female
    Humans
    Isoflavones
    Lignans
    Middle Aged
    Phytoestrogens
    Postmenopause
    Premenopause
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17992574

    Citation

    Cotterchio, Michelle, et al. "Dietary Phytoestrogen Intake--lignans and Isoflavones--and Breast Cancer Risk (Canada)." Cancer Causes & Control : CCC, vol. 19, no. 3, 2008, pp. 259-72.
    Cotterchio M, Boucher BA, Kreiger N, et al. Dietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada). Cancer Causes Control. 2008;19(3):259-72.
    Cotterchio, M., Boucher, B. A., Kreiger, N., Mills, C. A., & Thompson, L. U. (2008). Dietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada). Cancer Causes & Control : CCC, 19(3), pp. 259-72.
    Cotterchio M, et al. Dietary Phytoestrogen Intake--lignans and Isoflavones--and Breast Cancer Risk (Canada). Cancer Causes Control. 2008;19(3):259-72. PubMed PMID: 17992574.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada). AU - Cotterchio,Michelle, AU - Boucher,Beatrice A, AU - Kreiger,Nancy, AU - Mills,Catherine A, AU - Thompson,Lilian U, Y1 - 2007/11/09/ PY - 2007/06/11/received PY - 2007/10/19/accepted PY - 2007/11/10/pubmed PY - 2008/9/17/medline PY - 2007/11/10/entrez SP - 259 EP - 72 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 3 N2 - OBJECTIVE: To evaluate whether phytoestrogen intake is associated with reduced breast cancer risk, using a novel phytoestrogen database. METHODS: Population-based breast cancer cases aged 25-74 years (diagnosed 2002-2003) were identified using Ontario Cancer Registry (n = 3,063) and controls (n = 3,430) were an age-stratified random sample of women identified through random digit dialing. An epidemiologic and Block food frequency questionnaire--expanded to include phytoestrogen-containing foods--was mailed to all subjects. The recently published Ontario phytoestrogen database was applied to FFQ responses to estimate intake. Multivariate logistic regression provided odds ratio (OR) estimates, while controlling for confounders. RESULTS: Among all women, lignan intake was associated with a reduced breast cancer risk (Q5 vs. Q1 MVOR: 0.81, 95% CI: 0.65, 0.99); however, following stratification by BMI, this reduction in risk was statistically significant only among overweight (BMI > 25) women. Total phytoestrogen intake was also associated with a risk reduction among overweight women only. Among pre-menopausal women, total phytoestrogen intake was associated with a significant reduction in breast cancer risk among overweight women only (Q5 vs. Q1 MVOR: 0.51, 95% CI: 0.30, 0.87). Among post-menopausal women, no statistically significant association was observed between breast cancer risk and isoflavones or lignans. CONCLUSION: Lignan intake may be associated with reduced breast cancer risk among pre-menopausal women, and our data suggest BMI modifies this association. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17992574/Dietary_phytoestrogen_intake__lignans_and_isoflavones__and_breast_cancer_risk__Canada__ L2 - https://doi.org/10.1007/s10552-007-9089-2 DB - PRIME DP - Unbound Medicine ER -