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Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma.
Cancer Causes Control. 2008 Mar; 19(2):125-34.CC

Abstract

OBJECTIVE

We investigated whether dietary carotenoid and vitamin intake and supplemental vitamin use were inversely associated with RCC risk and with Von Hippel-Lindau (VHL)-gene mutations in clear-cell renal cell carcinoma (RCC).

METHODS

The Netherlands Cohort Study on diet and cancer (NLCS) includes 120,852 persons, who completed a self-administered food-frequency questionnaire in 1986. After 11.3 years of follow-up, 284 cases and a random sample of 4,095 persons (subcohort) with complete data were included in multivariable analyses using a case-cohort approach. VHL gene mutational analysis was complete for 225 cases. Rate ratios and corresponding 95% confidence intervals were estimated using Cox proportional hazard models, while adjusting for age, sex, smoking, body mass index, and a history of hypertension.

RESULTS

We observed no association for dietary carotenoid and vitamin intake and RCC risk, and a somewhat increased risk with supplemental vitamin E, AD, and multivitamin use. Results were suggestive of higher RRs for alpha-carotene, beta-cryptoxanthin, folate, and supplemental vitamin C and multivitamin intake for wildtype VHL tumors compared to VHL-mutated tumors.

CONCLUSIONS

There was no association of carotenoid, vitamin or supplemental vitamin intake and RCC risk. These associations should be investigated by others to confirm the current observations.

Authors+Show Affiliations

Department of Epidemiology, NUTRIM, Maastricht University, Maastricht, The Netherlands. b.vandijk@akc.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17992578

Citation

van Dijk, Boukje A C., et al. "Carotenoid and Vitamin Intake, Von Hippel-Lindau Gene Mutations and Sporadic Renal Cell Carcinoma." Cancer Causes & Control : CCC, vol. 19, no. 2, 2008, pp. 125-34.
van Dijk BA, Schouten LJ, Oosterwijk E, et al. Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma. Cancer Causes Control. 2008;19(2):125-34.
van Dijk, B. A., Schouten, L. J., Oosterwijk, E., Hulsbergen-van de Kaa, C. A., Kiemeney, L. A., Goldbohm, R. A., Schalken, J. A., & van den Brandt, P. A. (2008). Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma. Cancer Causes & Control : CCC, 19(2), 125-34.
van Dijk BA, et al. Carotenoid and Vitamin Intake, Von Hippel-Lindau Gene Mutations and Sporadic Renal Cell Carcinoma. Cancer Causes Control. 2008;19(2):125-34. PubMed PMID: 17992578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma. AU - van Dijk,Boukje A C, AU - Schouten,Leo J, AU - Oosterwijk,Egbert, AU - Hulsbergen-van de Kaa,Christina A, AU - Kiemeney,Lambertus A L M, AU - Goldbohm,R Alexandra, AU - Schalken,Jack A, AU - van den Brandt,Piet A, Y1 - 2007/11/09/ PY - 2007/01/10/received PY - 2007/10/04/accepted PY - 2007/11/10/pubmed PY - 2008/6/5/medline PY - 2007/11/10/entrez SP - 125 EP - 34 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 2 N2 - OBJECTIVE: We investigated whether dietary carotenoid and vitamin intake and supplemental vitamin use were inversely associated with RCC risk and with Von Hippel-Lindau (VHL)-gene mutations in clear-cell renal cell carcinoma (RCC). METHODS: The Netherlands Cohort Study on diet and cancer (NLCS) includes 120,852 persons, who completed a self-administered food-frequency questionnaire in 1986. After 11.3 years of follow-up, 284 cases and a random sample of 4,095 persons (subcohort) with complete data were included in multivariable analyses using a case-cohort approach. VHL gene mutational analysis was complete for 225 cases. Rate ratios and corresponding 95% confidence intervals were estimated using Cox proportional hazard models, while adjusting for age, sex, smoking, body mass index, and a history of hypertension. RESULTS: We observed no association for dietary carotenoid and vitamin intake and RCC risk, and a somewhat increased risk with supplemental vitamin E, AD, and multivitamin use. Results were suggestive of higher RRs for alpha-carotene, beta-cryptoxanthin, folate, and supplemental vitamin C and multivitamin intake for wildtype VHL tumors compared to VHL-mutated tumors. CONCLUSIONS: There was no association of carotenoid, vitamin or supplemental vitamin intake and RCC risk. These associations should be investigated by others to confirm the current observations. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17992578/Carotenoid_and_vitamin_intake_von_Hippel_Lindau_gene_mutations_and_sporadic_renal_cell_carcinoma_ L2 - https://doi.org/10.1007/s10552-007-9078-5 DB - PRIME DP - Unbound Medicine ER -