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Inhibitors of osteoclast differentiation from Cephalotaxus koreana.
J Nat Prod. 2007 Dec; 70(12):2029-32.JN

Abstract

Three new flavonoid glycosides (1- 3), 11-hydroxyhainanolidol (4), and a new dibenzylbutyrolactone lignan glycoside (5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids. The structures of the new compounds were elucidated using spectroscopic evidence, primarily NMR and MS. Twenty-four compounds were isolated, and among these isoscutellarein 5-O-beta-D-glucopyranoside (3), apigenin (6), kaempferol 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside (7), tamarixetin 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside (8), quercetin 3-O-[6''-O-acetyl]-beta-D-glucopyranoside (9), and quercetin 3-O-alpha-L-rhamnopyranoside (10) showed significant inhibitory activities against osteoclast differentiation at concentrations of 0.1 and 1.0 microg/mL.

Authors+Show Affiliations

Yoon KD
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
Jeong DG
No affiliation info available
Hwang YH
No affiliation info available
Ryu JM
No affiliation info available
Kim J
No affiliation info available

MeSH

Cell DifferentiationCephalotaxusDose-Response Relationship, DrugFlavonoidsGlucosidesGlycosidesKoreaMolecular StructureOsteoclastsPlants, Medicinal

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17994703

Citation

Yoon, Kee Dong, et al. "Inhibitors of Osteoclast Differentiation From Cephalotaxus Koreana." Journal of Natural Products, vol. 70, no. 12, 2007, pp. 2029-32.
Yoon KD, Jeong DG, Hwang YH, et al. Inhibitors of osteoclast differentiation from Cephalotaxus koreana. J Nat Prod. 2007;70(12):2029-32.
Yoon, K. D., Jeong, D. G., Hwang, Y. H., Ryu, J. M., & Kim, J. (2007). Inhibitors of osteoclast differentiation from Cephalotaxus koreana. Journal of Natural Products, 70(12), 2029-32.
Yoon KD, et al. Inhibitors of Osteoclast Differentiation From Cephalotaxus Koreana. J Nat Prod. 2007;70(12):2029-32. PubMed PMID: 17994703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitors of osteoclast differentiation from Cephalotaxus koreana. AU - Yoon,Kee Dong, AU - Jeong,Doc Gyun, AU - Hwang,Yun Ha, AU - Ryu,Jei Man, AU - Kim,Jinwoong, Y1 - 2007/11/10/ PY - 2007/11/13/pubmed PY - 2008/3/7/medline PY - 2007/11/13/entrez SP - 2029 EP - 32 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 12 N2 - Three new flavonoid glycosides (1- 3), 11-hydroxyhainanolidol (4), and a new dibenzylbutyrolactone lignan glycoside (5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids. The structures of the new compounds were elucidated using spectroscopic evidence, primarily NMR and MS. Twenty-four compounds were isolated, and among these isoscutellarein 5-O-beta-D-glucopyranoside (3), apigenin (6), kaempferol 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside (7), tamarixetin 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside (8), quercetin 3-O-[6''-O-acetyl]-beta-D-glucopyranoside (9), and quercetin 3-O-alpha-L-rhamnopyranoside (10) showed significant inhibitory activities against osteoclast differentiation at concentrations of 0.1 and 1.0 microg/mL. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17994703/Inhibitors_of_osteoclast_differentiation_from_Cephalotaxus_koreana_ DB - PRIME DP - Unbound Medicine ER -