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Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand.
J Child Psychol Psychiatry. 2007 Nov; 48(11):1071-9.JC

Abstract

BACKGROUND

Attention-deficit/hyperactivity disorder (ADHD) is strongly influenced by heritability. Identifying heritable vulnerability traits (endophenotypes) that mark a relatively high risk of developing the disorder can contribute to the identification of risk genes. A fruitful area for the search for such endophenotypes may be motor control in children with ADHD, since the disorder is frequently accompanied by motor problems.

METHOD

The current study used a large sample of 350 children with ADHD, 195 non-affected siblings and 271 normal controls aged 5-19 years. Children were administered two computerised motor control tasks in which they had to trace a path between two circles (Tracking task) and follow a randomly moving target (Pursuit task). Both tasks were performed with both the right and the left hand.

RESULTS

Children with ADHD were less precise and stable than controls. Non-affected siblings also deviated from controls, but only on the Tracking task. Group differences were modulated by the use of the right versus the left hand: no group differences emerged when the right hand was used, yet group differences did emerge when the left hand was used. Performance on both tasks was significantly familial.

CONCLUSIONS

Imprecision and instability of movements in children with ADHD and in their non-affected siblings as measured by the Tracking task might be suitable endophenotypic candidates: these deficits are familially present in children having ADHD as well as in their non-affected siblings. Motor performance might be best assessed in children using their left hand, because motor control deficits are most pronounced using the left hand. This might relate to right hemispheric brain pathology in children with ADHD (and possibly in their non-affected siblings) that is related to the control of the left hand and/or relate to differential effects of daily life practice on both hands, which may be smaller on the left hand.

Authors+Show Affiliations

Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. nnj.rommelse@psy.vu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17995482

Citation

Rommelse, Nanda N J., et al. "Motor Control in Children With ADHD and Non-affected Siblings: Deficits Most Pronounced Using the Left Hand." Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 48, no. 11, 2007, pp. 1071-9.
Rommelse NN, Altink ME, Oosterlaan J, et al. Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand. J Child Psychol Psychiatry. 2007;48(11):1071-9.
Rommelse, N. N., Altink, M. E., Oosterlaan, J., Buschgens, C. J., Buitelaar, J., De Sonneville, L. M., & Sergeant, J. A. (2007). Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 48(11), 1071-9.
Rommelse NN, et al. Motor Control in Children With ADHD and Non-affected Siblings: Deficits Most Pronounced Using the Left Hand. J Child Psychol Psychiatry. 2007;48(11):1071-9. PubMed PMID: 17995482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand. AU - Rommelse,Nanda N J, AU - Altink,Marieke E, AU - Oosterlaan,Jaap, AU - Buschgens,Cathelijne J M, AU - Buitelaar,Jan, AU - De Sonneville,Leo M J, AU - Sergeant,Joseph A, PY - 2007/11/13/pubmed PY - 2008/2/20/medline PY - 2007/11/13/entrez SP - 1071 EP - 9 JF - Journal of child psychology and psychiatry, and allied disciplines JO - J Child Psychol Psychiatry VL - 48 IS - 11 N2 - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is strongly influenced by heritability. Identifying heritable vulnerability traits (endophenotypes) that mark a relatively high risk of developing the disorder can contribute to the identification of risk genes. A fruitful area for the search for such endophenotypes may be motor control in children with ADHD, since the disorder is frequently accompanied by motor problems. METHOD: The current study used a large sample of 350 children with ADHD, 195 non-affected siblings and 271 normal controls aged 5-19 years. Children were administered two computerised motor control tasks in which they had to trace a path between two circles (Tracking task) and follow a randomly moving target (Pursuit task). Both tasks were performed with both the right and the left hand. RESULTS: Children with ADHD were less precise and stable than controls. Non-affected siblings also deviated from controls, but only on the Tracking task. Group differences were modulated by the use of the right versus the left hand: no group differences emerged when the right hand was used, yet group differences did emerge when the left hand was used. Performance on both tasks was significantly familial. CONCLUSIONS: Imprecision and instability of movements in children with ADHD and in their non-affected siblings as measured by the Tracking task might be suitable endophenotypic candidates: these deficits are familially present in children having ADHD as well as in their non-affected siblings. Motor performance might be best assessed in children using their left hand, because motor control deficits are most pronounced using the left hand. This might relate to right hemispheric brain pathology in children with ADHD (and possibly in their non-affected siblings) that is related to the control of the left hand and/or relate to differential effects of daily life practice on both hands, which may be smaller on the left hand. SN - 0021-9630 UR - https://www.unboundmedicine.com/medline/citation/17995482/Motor_control_in_children_with_ADHD_and_non_affected_siblings:_deficits_most_pronounced_using_the_left_hand_ L2 - https://doi.org/10.1111/j.1469-7610.2007.01781.x DB - PRIME DP - Unbound Medicine ER -