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Risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2 in former kidney donors.
Nephrology (Carlton). 2007 Dec; 12(6):600-6.N

Abstract

BACKGROUND

Although several previous studies have reported that kidney donors are not at increased risk for adverse effects, some donors have been found to progress to chronic kidney disease (CKD). We retrospectively evaluated the risk factors for estimated glomerular filtration rate (GFR) from abbreviated Modification of Diet in Renal Disease (MDRD) equation (MDRD-GFR) of less than 60 mL/min per 1.73 m2 in kidney donors.

METHODS

Of the 756 individuals who underwent open donor nephrectomy between 27 June 1990 and 30 April 2001, 104 had follow-up records for 50 months or more. MDRD-GFR of 60 mL/min per 1.73 m2 at final follow up divided these individuals into a normal group (n = 78) and a CKD-GFR group (n = 26). We compared several clinical parameters between the two groups at baseline and follow up to evaluate the risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2 in kidney donors.

RESULTS

The CKD-GFR group was significantly older than the normal group at baseline (47 +/- 12 vs 41 +/- 11 years old, P = 0.02). Hypertension was more prevalent in the CKD-GFR group at baseline (15% vs 2%, P = 0.005). Binary logistic regression analysis showed that age (Odds ratio (OR) 1.06, 95% confidence interval (CI) 1.01-1.10) and hypertension (OR 7.91, 95% CI 1.13-55.2) at baseline were independent risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2. At final follow up, the prevalence rates of hypertension (31% vs 8%, P = 0.006) and proteinuria (15% vs 0%, P = 0.003) were significantly higher in the CKD-GFR group.

CONCLUSION

Older kidney donors and those with hypertension were significantly more likely to have a MDRD-GFR of less than 60 mL/min per 1.73 m2.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17995588

Citation

Lee, Jang Han, et al. "Risk Factors for MDRD-GFR of Less Than 60 mL/min Per 1.73 M2 in Former Kidney Donors." Nephrology (Carlton, Vic.), vol. 12, no. 6, 2007, pp. 600-6.
Lee JH, Kim SC, Han DJ, et al. Risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2 in former kidney donors. Nephrology (Carlton). 2007;12(6):600-6.
Lee, J. H., Kim, S. C., Han, D. J., Chang, J. W., Yang, W. S., Park, S. K., Lee, S. K., Park, J. S., & Kim, S. B. (2007). Risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2 in former kidney donors. Nephrology (Carlton, Vic.), 12(6), 600-6.
Lee JH, et al. Risk Factors for MDRD-GFR of Less Than 60 mL/min Per 1.73 M2 in Former Kidney Donors. Nephrology (Carlton). 2007;12(6):600-6. PubMed PMID: 17995588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2 in former kidney donors. AU - Lee,Jang Han, AU - Kim,Song Cheol, AU - Han,Duck Jong, AU - Chang,Jai Won, AU - Yang,Won Seok, AU - Park,Su Kil, AU - Lee,Sang Koo, AU - Park,Jung Sik, AU - Kim,Soon Bae, PY - 2007/11/13/pubmed PY - 2008/5/31/medline PY - 2007/11/13/entrez SP - 600 EP - 6 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 12 IS - 6 N2 - BACKGROUND: Although several previous studies have reported that kidney donors are not at increased risk for adverse effects, some donors have been found to progress to chronic kidney disease (CKD). We retrospectively evaluated the risk factors for estimated glomerular filtration rate (GFR) from abbreviated Modification of Diet in Renal Disease (MDRD) equation (MDRD-GFR) of less than 60 mL/min per 1.73 m2 in kidney donors. METHODS: Of the 756 individuals who underwent open donor nephrectomy between 27 June 1990 and 30 April 2001, 104 had follow-up records for 50 months or more. MDRD-GFR of 60 mL/min per 1.73 m2 at final follow up divided these individuals into a normal group (n = 78) and a CKD-GFR group (n = 26). We compared several clinical parameters between the two groups at baseline and follow up to evaluate the risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2 in kidney donors. RESULTS: The CKD-GFR group was significantly older than the normal group at baseline (47 +/- 12 vs 41 +/- 11 years old, P = 0.02). Hypertension was more prevalent in the CKD-GFR group at baseline (15% vs 2%, P = 0.005). Binary logistic regression analysis showed that age (Odds ratio (OR) 1.06, 95% confidence interval (CI) 1.01-1.10) and hypertension (OR 7.91, 95% CI 1.13-55.2) at baseline were independent risk factors for MDRD-GFR of less than 60 mL/min per 1.73 m2. At final follow up, the prevalence rates of hypertension (31% vs 8%, P = 0.006) and proteinuria (15% vs 0%, P = 0.003) were significantly higher in the CKD-GFR group. CONCLUSION: Older kidney donors and those with hypertension were significantly more likely to have a MDRD-GFR of less than 60 mL/min per 1.73 m2. SN - 1320-5358 UR - https://www.unboundmedicine.com/medline/citation/17995588/Risk_factors_for_MDRD_GFR_of_less_than_60_mL/min_per_1_73_m2_in_former_kidney_donors_ L2 - https://doi.org/10.1111/j.1440-1797.2007.00852.x DB - PRIME DP - Unbound Medicine ER -