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Brain activation and defensive response mobilization during sustained exposure to phobia-related and other affective pictures in spider phobia.
Psychophysiology. 2008 Mar; 45(2):205-15.P

Abstract

This study explored defensive response mobilization as well as fMRI responses during sustained exposure to phobia-relevant stimuli. To test the specificity of affective physiology and brain activation, neutral and other affective stimuli were included. Phobia-specific startle potentiation was maintained and autonomic responses even increased during sustained phobic stimulation. Viewing of spider pictures also resulted in increased activation of the amygdala in spider-phobic participants. This effect, however, was not fear specific because other affective materials evoked comparable signal strength in the amygdala. In contrast, insula activation was specifically increased during sustained phobic exposure in phobic volunteers. These data suggest that the activation of the amygdala in fMRI studies primarily indexes the detection of motivationally relevant stimuli whereas the insula might be more specifically linked to defensive response mobilization.

Authors+Show Affiliations

Department of Psychology, University of Greifswald, Greifswald, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17995911

Citation

Wendt, Julia, et al. "Brain Activation and Defensive Response Mobilization During Sustained Exposure to Phobia-related and Other Affective Pictures in Spider Phobia." Psychophysiology, vol. 45, no. 2, 2008, pp. 205-15.
Wendt J, Lotze M, Weike AI, et al. Brain activation and defensive response mobilization during sustained exposure to phobia-related and other affective pictures in spider phobia. Psychophysiology. 2008;45(2):205-15.
Wendt, J., Lotze, M., Weike, A. I., Hosten, N., & Hamm, A. O. (2008). Brain activation and defensive response mobilization during sustained exposure to phobia-related and other affective pictures in spider phobia. Psychophysiology, 45(2), 205-15.
Wendt J, et al. Brain Activation and Defensive Response Mobilization During Sustained Exposure to Phobia-related and Other Affective Pictures in Spider Phobia. Psychophysiology. 2008;45(2):205-15. PubMed PMID: 17995911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain activation and defensive response mobilization during sustained exposure to phobia-related and other affective pictures in spider phobia. AU - Wendt,Julia, AU - Lotze,Martin, AU - Weike,Almut I, AU - Hosten,Norbert, AU - Hamm,Alfons O, Y1 - 2007/11/07/ PY - 2007/11/13/pubmed PY - 2008/4/10/medline PY - 2007/11/13/entrez SP - 205 EP - 15 JF - Psychophysiology JO - Psychophysiology VL - 45 IS - 2 N2 - This study explored defensive response mobilization as well as fMRI responses during sustained exposure to phobia-relevant stimuli. To test the specificity of affective physiology and brain activation, neutral and other affective stimuli were included. Phobia-specific startle potentiation was maintained and autonomic responses even increased during sustained phobic stimulation. Viewing of spider pictures also resulted in increased activation of the amygdala in spider-phobic participants. This effect, however, was not fear specific because other affective materials evoked comparable signal strength in the amygdala. In contrast, insula activation was specifically increased during sustained phobic exposure in phobic volunteers. These data suggest that the activation of the amygdala in fMRI studies primarily indexes the detection of motivationally relevant stimuli whereas the insula might be more specifically linked to defensive response mobilization. SN - 0048-5772 UR - https://www.unboundmedicine.com/medline/citation/17995911/Brain_activation_and_defensive_response_mobilization_during_sustained_exposure_to_phobia_related_and_other_affective_pictures_in_spider_phobia_ L2 - https://doi.org/10.1111/j.1469-8986.2007.00620.x DB - PRIME DP - Unbound Medicine ER -