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Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe.
Biosens Bioelectron. 2008 Jan 18; 23(6):886-91.BB

Abstract

We report pH sensing for biological applications based on surface enhanced Raman scattering (SERS) from silver nanoparticles functionalized with 2-aminothiophenol (2-aminobenzenethiol, 2-ABT). pH-dependent SERS spectra of the attached 2-ABT molecules enable one to sense the pH over the range of 3.0-8.0. We have performed the first demonstration of SERS detection in living cells kept in different pH buffer solutions and show that the pH sensitivity is retained in that case. Thus, the nanoparticles can be used as probes delivering spatially localized chemical information from biological environments and provide a new way to monitor chemical changes at cellular level.

Authors+Show Affiliations

Wang Z
Institute for Lasers, Photonics and Biophotonics, SUNY at Buffalo, Buffalo, NY 14260, United States.
Bonoiu A
No affiliation info available
Samoc M
No affiliation info available
Cui Y
No affiliation info available
Prasad PN
No affiliation info available

MeSH

Aniline CompoundsBiosensing TechniquesHydrogen-Ion ConcentrationMetal NanoparticlesSilverSpectrum Analysis, RamanSurface Properties

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17996441

Citation

Wang, Zhuyuan, et al. "Biological pH Sensing Based On Surface Enhanced Raman Scattering Through a 2-aminothiophenol-silver Probe." Biosensors & Bioelectronics, vol. 23, no. 6, 2008, pp. 886-91.
Wang Z, Bonoiu A, Samoc M, et al. Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe. Biosens Bioelectron. 2008;23(6):886-91.
Wang, Z., Bonoiu, A., Samoc, M., Cui, Y., & Prasad, P. N. (2008). Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe. Biosensors & Bioelectronics, 23(6), 886-91.
Wang Z, et al. Biological pH Sensing Based On Surface Enhanced Raman Scattering Through a 2-aminothiophenol-silver Probe. Biosens Bioelectron. 2008 Jan 18;23(6):886-91. PubMed PMID: 17996441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe. AU - Wang,Zhuyuan, AU - Bonoiu,Adela, AU - Samoc,Marek, AU - Cui,Yiping, AU - Prasad,Paras N, Y1 - 2007/09/29/ PY - 2007/04/24/received PY - 2007/08/08/revised PY - 2007/09/14/accepted PY - 2007/11/13/pubmed PY - 2008/3/7/medline PY - 2007/11/13/entrez SP - 886 EP - 91 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 23 IS - 6 N2 - We report pH sensing for biological applications based on surface enhanced Raman scattering (SERS) from silver nanoparticles functionalized with 2-aminothiophenol (2-aminobenzenethiol, 2-ABT). pH-dependent SERS spectra of the attached 2-ABT molecules enable one to sense the pH over the range of 3.0-8.0. We have performed the first demonstration of SERS detection in living cells kept in different pH buffer solutions and show that the pH sensitivity is retained in that case. Thus, the nanoparticles can be used as probes delivering spatially localized chemical information from biological environments and provide a new way to monitor chemical changes at cellular level. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/17996441/Biological_pH_sensing_based_on_surface_enhanced_Raman_scattering_through_a_2_aminothiophenol_silver_probe_ DB - PRIME DP - Unbound Medicine ER -