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Role of genetic factors in polio eradication: new challenge for policy makers.
Vaccine 2007; 25(50):8365-71V

Abstract

In 1988 the World Health Assembly passed resolution WHA 41.28, for global eradication of poliomyelitis by the year 2000 by providing immunization exclusively with oral polio vaccine (OPV). India happens to be the largest country in the world, where polio cases are occurring in large numbers. Despite increase in number of pulse polio immunization (PPI) rounds and introduction of monovalent oral polio vaccines mOPV1 and mOPV3, polio has not been eradicated from India. Global polio eradication cannot be achieved unless polio is eradicated from India because of the risk of exportation of wild poliovirus to other countries. India cannot become polio free unless Uttar Pradesh and Bihar become polio free. Because of genetic and some other factors, OPV cannot eradicate polio from Bihar and Uttar Pradesh. The present scenario strongly suggests that due to some host factors in recipients OPV cannot eradicate polio. Rather than extending the deadline for polio eradication again and again, it is time to prepare strategy for final push to polio.

Authors+Show Affiliations

Maharaja Agrasen Hospital, Vidhyadhar Nagar, Jaipur 302023, India. dryashpaul2003@yahoo.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17996995

Citation

Paul, Yash. "Role of Genetic Factors in Polio Eradication: New Challenge for Policy Makers." Vaccine, vol. 25, no. 50, 2007, pp. 8365-71.
Paul Y. Role of genetic factors in polio eradication: new challenge for policy makers. Vaccine. 2007;25(50):8365-71.
Paul, Y. (2007). Role of genetic factors in polio eradication: new challenge for policy makers. Vaccine, 25(50), pp. 8365-71.
Paul Y. Role of Genetic Factors in Polio Eradication: New Challenge for Policy Makers. Vaccine. 2007 Dec 5;25(50):8365-71. PubMed PMID: 17996995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of genetic factors in polio eradication: new challenge for policy makers. A1 - Paul,Yash, Y1 - 2007/10/17/ PY - 2007/08/15/received PY - 2007/09/21/revised PY - 2007/09/25/accepted PY - 2007/11/13/pubmed PY - 2008/2/27/medline PY - 2007/11/13/entrez SP - 8365 EP - 71 JF - Vaccine JO - Vaccine VL - 25 IS - 50 N2 - In 1988 the World Health Assembly passed resolution WHA 41.28, for global eradication of poliomyelitis by the year 2000 by providing immunization exclusively with oral polio vaccine (OPV). India happens to be the largest country in the world, where polio cases are occurring in large numbers. Despite increase in number of pulse polio immunization (PPI) rounds and introduction of monovalent oral polio vaccines mOPV1 and mOPV3, polio has not been eradicated from India. Global polio eradication cannot be achieved unless polio is eradicated from India because of the risk of exportation of wild poliovirus to other countries. India cannot become polio free unless Uttar Pradesh and Bihar become polio free. Because of genetic and some other factors, OPV cannot eradicate polio from Bihar and Uttar Pradesh. The present scenario strongly suggests that due to some host factors in recipients OPV cannot eradicate polio. Rather than extending the deadline for polio eradication again and again, it is time to prepare strategy for final push to polio. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/17996995/Role_of_genetic_factors_in_polio_eradication:_new_challenge_for_policy_makers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(07)01125-5 DB - PRIME DP - Unbound Medicine ER -