Tags

Type your tag names separated by a space and hit enter

Relationship between Helicobacter pylori infection and esophageal neoplasia: a meta-analysis.
Clin Gastroenterol Hepatol 2007; 5(12):1413-7, 1417.e1-2CG

Abstract

BACKGROUND & AIMS

Helicobacter pylori is an important causative factor in gastric carcinogenesis. However, its role in extragastric gastrointestinal malignancies, such as esophageal cancer, is controversial. The aim of this study was to explore the relationship of H. pylori infection and H. pylori cagA-positive strain with this malignancy by performing meta-analysis of all relevant studies.

METHODS

Extensive MEDLINE English language medical literature searches for human studies were performed through February 2007 with suitable keywords. Pooled estimates were obtained by using fixed or random-effects model as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test, whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the Begg and Mazumdar adjusted rank correlation test.

RESULTS

In adenocarcinoma patients there were inverse significant relationships with both the H. pylori prevalence (pooled odds ratio [OR], 0.52; 95% confidence interval [CI], 0.37-0.73; P < .001) and the prevalence of H. pylori cagA-positive strain (pooled OR, 0.51; 95% CI, 0.31-0.82; P = .006). Similarly in patients with Barrett's esophagus there were inverse significant relationships (pooled OR, 0.64; 95% CI, 0.43-0.94; P = .025 and pooled OR, 0.39; 95% CI, 0.21-0.76; P = .005, respectively). In patients with squamous cell carcinoma there were no significant relationships with both H. pylori prevalence (pooled OR, 0.85; 95% CI, 0.55-1.33; P = .48) and the prevalence of H. pylori cagA-positive strains (pooled OR, 1.22; 95% CI, 0.7-2.13; P = .48).

CONCLUSIONS

The results showed an inverse statistically significant relationship of H. pylori infection with both esophageal adenocarcinoma and Barrett's esophagus, which might suggest a protective role of the infection in these entities. On the contrary, no statistically significant relationship with squamous cell carcinoma was found.

Authors+Show Affiliations

Gastroenterology Clinic, Henry Dunant Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

17997357

Citation

Rokkas, Theodoros, et al. "Relationship Between Helicobacter Pylori Infection and Esophageal Neoplasia: a Meta-analysis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 12, 2007, pp. 1413-7, 1417.e1-2.
Rokkas T, Pistiolas D, Sechopoulos P, et al. Relationship between Helicobacter pylori infection and esophageal neoplasia: a meta-analysis. Clin Gastroenterol Hepatol. 2007;5(12):1413-7, 1417.e1-2.
Rokkas, T., Pistiolas, D., Sechopoulos, P., Robotis, I., & Margantinis, G. (2007). Relationship between Helicobacter pylori infection and esophageal neoplasia: a meta-analysis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(12), pp. 1413-7, 1417.e1-2.
Rokkas T, et al. Relationship Between Helicobacter Pylori Infection and Esophageal Neoplasia: a Meta-analysis. Clin Gastroenterol Hepatol. 2007;5(12):1413-7, 1417.e1-2. PubMed PMID: 17997357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between Helicobacter pylori infection and esophageal neoplasia: a meta-analysis. AU - Rokkas,Theodoros, AU - Pistiolas,Dimitrios, AU - Sechopoulos,Panos, AU - Robotis,Ioannis, AU - Margantinis,Georgios, Y1 - 2007/11/07/ PY - 2007/11/13/pubmed PY - 2008/1/18/medline PY - 2007/11/13/entrez SP - 1413-7, 1417.e1-2 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 5 IS - 12 N2 - BACKGROUND & AIMS: Helicobacter pylori is an important causative factor in gastric carcinogenesis. However, its role in extragastric gastrointestinal malignancies, such as esophageal cancer, is controversial. The aim of this study was to explore the relationship of H. pylori infection and H. pylori cagA-positive strain with this malignancy by performing meta-analysis of all relevant studies. METHODS: Extensive MEDLINE English language medical literature searches for human studies were performed through February 2007 with suitable keywords. Pooled estimates were obtained by using fixed or random-effects model as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test, whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the Begg and Mazumdar adjusted rank correlation test. RESULTS: In adenocarcinoma patients there were inverse significant relationships with both the H. pylori prevalence (pooled odds ratio [OR], 0.52; 95% confidence interval [CI], 0.37-0.73; P < .001) and the prevalence of H. pylori cagA-positive strain (pooled OR, 0.51; 95% CI, 0.31-0.82; P = .006). Similarly in patients with Barrett's esophagus there were inverse significant relationships (pooled OR, 0.64; 95% CI, 0.43-0.94; P = .025 and pooled OR, 0.39; 95% CI, 0.21-0.76; P = .005, respectively). In patients with squamous cell carcinoma there were no significant relationships with both H. pylori prevalence (pooled OR, 0.85; 95% CI, 0.55-1.33; P = .48) and the prevalence of H. pylori cagA-positive strains (pooled OR, 1.22; 95% CI, 0.7-2.13; P = .48). CONCLUSIONS: The results showed an inverse statistically significant relationship of H. pylori infection with both esophageal adenocarcinoma and Barrett's esophagus, which might suggest a protective role of the infection in these entities. On the contrary, no statistically significant relationship with squamous cell carcinoma was found. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17997357/Relationship_between_Helicobacter_pylori_infection_and_esophageal_neoplasia:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)00768-9 DB - PRIME DP - Unbound Medicine ER -