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Impact of visual field loss on health-related quality of life in glaucoma: the Los Angeles Latino Eye Study.
Ophthalmology 2008; 115(6):941-948.e1O

Abstract

PURPOSE

To examine the association between health-related quality of life (HRQOL) and visual field (VF) loss in participants with open-angle glaucoma (OAG) in the Los Angeles Latino Eye Study (LALES).

DESIGN

Population-based cross-sectional study.

PARTICIPANTS

Two hundred thirteen participants with OAG and 2821 participants without glaucoma or VF loss.

METHODS

Participants in the LALES-a population-based prevalence study of eye disease in Latinos 40 years and older, residing in Los Angeles, California-underwent a detailed eye examination including an assessment of their VF using the Humphrey Automated Field Analyzer (Swedish interactive thresholding algorithm Standard 24-2). Open-angle glaucoma was determined by clinical examination. Mean deviation scores were used to assess severity of VF loss. Health-related QOL was assessed by the Medical Outcomes Study 12-item Short-Form Health Survey (SF-12) and 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). Linear regression and analysis of covariance were used to assess the relationship between HRQOL scores and VF loss after adjusting for sociodemographic variables and visual acuity.

MAIN OUTCOME MEASURES

The 25-item NEI-VFQ and SF-12 scores.

RESULTS

A trend of worse NEI-VFQ-25 scores for most subscales was observed with worse VF loss (using both monocular and calculated binocular data). Open-angle glaucoma participants with VF loss had lower scores than participants with no VF loss. This association was also present in participants who were previously undiagnosed and untreated for OAG (N = 160). Participants with any central VF loss had lower NEI-VFQ-25 scores than those with unilateral or bilateral peripheral VF loss. There was no significant impact of severity or location of VF loss on SF-12 scores.

CONCLUSION

Greater severity of VF loss in persons with OAG impacts vision-related QOL. This impact was present in persons who were previously unaware that they had glaucoma. Prevention of VF loss in persons with glaucoma is likely to reduce loss of vision-related QOL.

Authors+Show Affiliations

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17997485

Citation

McKean-Cowdin, Roberta, et al. "Impact of Visual Field Loss On Health-related Quality of Life in Glaucoma: the Los Angeles Latino Eye Study." Ophthalmology, vol. 115, no. 6, 2008, pp. 941-948.e1.
McKean-Cowdin R, Wang Y, Wu J, et al. Impact of visual field loss on health-related quality of life in glaucoma: the Los Angeles Latino Eye Study. Ophthalmology. 2008;115(6):941-948.e1.
McKean-Cowdin, R., Wang, Y., Wu, J., Azen, S. P., & Varma, R. (2008). Impact of visual field loss on health-related quality of life in glaucoma: the Los Angeles Latino Eye Study. Ophthalmology, 115(6), pp. 941-948.e1.
McKean-Cowdin R, et al. Impact of Visual Field Loss On Health-related Quality of Life in Glaucoma: the Los Angeles Latino Eye Study. Ophthalmology. 2008;115(6):941-948.e1. PubMed PMID: 17997485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of visual field loss on health-related quality of life in glaucoma: the Los Angeles Latino Eye Study. AU - McKean-Cowdin,Roberta, AU - Wang,Ying, AU - Wu,Joanne, AU - Azen,Stanley P, AU - Varma,Rohit, AU - ,, Y1 - 2007/11/12/ PY - 2007/04/03/received PY - 2007/08/09/revised PY - 2007/08/21/accepted PY - 2007/11/13/pubmed PY - 2008/6/13/medline PY - 2007/11/13/entrez SP - 941 EP - 948.e1 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 6 N2 - PURPOSE: To examine the association between health-related quality of life (HRQOL) and visual field (VF) loss in participants with open-angle glaucoma (OAG) in the Los Angeles Latino Eye Study (LALES). DESIGN: Population-based cross-sectional study. PARTICIPANTS: Two hundred thirteen participants with OAG and 2821 participants without glaucoma or VF loss. METHODS: Participants in the LALES-a population-based prevalence study of eye disease in Latinos 40 years and older, residing in Los Angeles, California-underwent a detailed eye examination including an assessment of their VF using the Humphrey Automated Field Analyzer (Swedish interactive thresholding algorithm Standard 24-2). Open-angle glaucoma was determined by clinical examination. Mean deviation scores were used to assess severity of VF loss. Health-related QOL was assessed by the Medical Outcomes Study 12-item Short-Form Health Survey (SF-12) and 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). Linear regression and analysis of covariance were used to assess the relationship between HRQOL scores and VF loss after adjusting for sociodemographic variables and visual acuity. MAIN OUTCOME MEASURES: The 25-item NEI-VFQ and SF-12 scores. RESULTS: A trend of worse NEI-VFQ-25 scores for most subscales was observed with worse VF loss (using both monocular and calculated binocular data). Open-angle glaucoma participants with VF loss had lower scores than participants with no VF loss. This association was also present in participants who were previously undiagnosed and untreated for OAG (N = 160). Participants with any central VF loss had lower NEI-VFQ-25 scores than those with unilateral or bilateral peripheral VF loss. There was no significant impact of severity or location of VF loss on SF-12 scores. CONCLUSION: Greater severity of VF loss in persons with OAG impacts vision-related QOL. This impact was present in persons who were previously unaware that they had glaucoma. Prevention of VF loss in persons with glaucoma is likely to reduce loss of vision-related QOL. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17997485/Impact_of_visual_field_loss_on_health_related_quality_of_life_in_glaucoma:_the_Los_Angeles_Latino_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00941-4 DB - PRIME DP - Unbound Medicine ER -