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Ligands for practical rhodium-catalyzed asymmetric hydroformylation.
Acc Chem Res. 2007 Dec; 40(12):1251-9.AC

Abstract

A series of bis-phosphite and bis-phosphine ligands for asymmetric hydroformylation reactions has been evaluated. Bis-phosphite ligands lead, in general, to high regioselectivities across a range of substrates while good enantioselectivities are limited to only a few examples. We found that bis-phospholane-type ligands, such as bis-diazaphospholanes and bis-phospholanes, can lead to very high regio- and enantioselectivities for several different substrates.

Authors+Show Affiliations

Klosin J
Corporate R&D, The Dow Chemical Company, 1776 Building, Midland, Michigan 48674, USA. jklosin@dow.com
Landis CR
No affiliation info available

MeSH

AldehydesCatalysisHydrogenationLigandsPhosphorus CompoundsRhodiumStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17997526

Citation

Klosin, Jerzy, and Clark R. Landis. "Ligands for Practical Rhodium-catalyzed Asymmetric Hydroformylation." Accounts of Chemical Research, vol. 40, no. 12, 2007, pp. 1251-9.
Klosin J, Landis CR. Ligands for practical rhodium-catalyzed asymmetric hydroformylation. Acc Chem Res. 2007;40(12):1251-9.
Klosin, J., & Landis, C. R. (2007). Ligands for practical rhodium-catalyzed asymmetric hydroformylation. Accounts of Chemical Research, 40(12), 1251-9.
Klosin J, Landis CR. Ligands for Practical Rhodium-catalyzed Asymmetric Hydroformylation. Acc Chem Res. 2007;40(12):1251-9. PubMed PMID: 17997526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ligands for practical rhodium-catalyzed asymmetric hydroformylation. AU - Klosin,Jerzy, AU - Landis,Clark R, Y1 - 2007/11/13/ PY - 2007/11/14/pubmed PY - 2008/3/7/medline PY - 2007/11/14/entrez SP - 1251 EP - 9 JF - Accounts of chemical research JO - Acc Chem Res VL - 40 IS - 12 N2 - A series of bis-phosphite and bis-phosphine ligands for asymmetric hydroformylation reactions has been evaluated. Bis-phosphite ligands lead, in general, to high regioselectivities across a range of substrates while good enantioselectivities are limited to only a few examples. We found that bis-phospholane-type ligands, such as bis-diazaphospholanes and bis-phospholanes, can lead to very high regio- and enantioselectivities for several different substrates. SN - 0001-4842 UR - https://www.unboundmedicine.com/medline/citation/17997526/Ligands_for_practical_rhodium_catalyzed_asymmetric_hydroformylation_ DB - PRIME DP - Unbound Medicine ER -