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[Effect of scalp acupuncture on inflammatory response in rats with acute cerebral ischemia-reperfusion injury].
Zhong Xi Yi Jie He Xue Bao 2007; 5(6):686-91ZX

Abstract

OBJECTIVE

To explore the mechanism of scalp acupuncture (SA) in treating cerebral ischemia.

METHODS

Sixty SD rats with middle cerebral artery occlusion (MCAO) were randomized into untreated group and SA-treated group, with another group of 10 SD rats without artery occlusion as sham-operated control. Neurological severity score (NSS), hemetoxylin and eosin (HE) staining and enzyme-linked immunosorbent assay were applied to observing the changes of neurofunctional defect, inflammatory infiltration in cerebral tissue and content of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-10 at 24, 48 and 72 h after ischemia-reperfusion.

RESULTS

There existed significant difference in NSS between SA-treated group and untreated group (P<0.01), especially at 72 h after ischemia-reperfusion. The HE staining results of ischemic cerebral tissue showed an apparent reduction of inflamed lesions in SA-treated group as compared with the untreated group (P<0.01), especially at 72 h after ischemia-reperfusion. The content of TNF-alpha and IL-1beta at each phase point after ischemia-reperfusion in SA-treated was decreased as compared with that in the untreated group, and there were differences between SA-treated group and untreated group at 72 h after ischemia-reperfusion (P<0.01). An apparent increase was observed in IL-10 between SA-treated group and untreated group at each phase point after ischemia-reperfusion, and there were significant differences between SA-treated group and untreated group at 48 and 72 h after ischemia-reperfusion (P<0.05, P<0.01).

CONCLUSION

Scalp acupuncture can improve neurofunctional rehabilitation, suppress leukocyte infiltration, decrease the content of TNF-alpha and IL-1beta within a certain range and enhance IL-10 expression so as to suppress cytokines-mediated inflammatory reaction and attenuate cerebral ischemia-reperfusion injury.

Authors+Show Affiliations

Department of Acupuncture & Moxibustion, Wuhan Chinese and Western Medicine Hospital, Wuhan, Hubei Province 430022, China. zhxzj99@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17997947

Citation

Zhang, Hong-xing, et al. "[Effect of Scalp Acupuncture On Inflammatory Response in Rats With Acute Cerebral Ischemia-reperfusion Injury]." Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, vol. 5, no. 6, 2007, pp. 686-91.
Zhang HX, Liu LG, Zhou L, et al. [Effect of scalp acupuncture on inflammatory response in rats with acute cerebral ischemia-reperfusion injury]. Zhong Xi Yi Jie He Xue Bao. 2007;5(6):686-91.
Zhang, H. X., Liu, L. G., Zhou, L., Huang, H., Li, X., & Yang, M. (2007). [Effect of scalp acupuncture on inflammatory response in rats with acute cerebral ischemia-reperfusion injury]. Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, 5(6), pp. 686-91.
Zhang HX, et al. [Effect of Scalp Acupuncture On Inflammatory Response in Rats With Acute Cerebral Ischemia-reperfusion Injury]. Zhong Xi Yi Jie He Xue Bao. 2007;5(6):686-91. PubMed PMID: 17997947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of scalp acupuncture on inflammatory response in rats with acute cerebral ischemia-reperfusion injury]. AU - Zhang,Hong-xing, AU - Liu,Ling-guang, AU - Zhou,Li, AU - Huang,Hao, AU - Li,Xuan, AU - Yang,Min, PY - 2007/11/14/pubmed PY - 2009/12/30/medline PY - 2007/11/14/entrez SP - 686 EP - 91 JF - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine JO - Zhong Xi Yi Jie He Xue Bao VL - 5 IS - 6 N2 - OBJECTIVE: To explore the mechanism of scalp acupuncture (SA) in treating cerebral ischemia. METHODS: Sixty SD rats with middle cerebral artery occlusion (MCAO) were randomized into untreated group and SA-treated group, with another group of 10 SD rats without artery occlusion as sham-operated control. Neurological severity score (NSS), hemetoxylin and eosin (HE) staining and enzyme-linked immunosorbent assay were applied to observing the changes of neurofunctional defect, inflammatory infiltration in cerebral tissue and content of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-10 at 24, 48 and 72 h after ischemia-reperfusion. RESULTS: There existed significant difference in NSS between SA-treated group and untreated group (P<0.01), especially at 72 h after ischemia-reperfusion. The HE staining results of ischemic cerebral tissue showed an apparent reduction of inflamed lesions in SA-treated group as compared with the untreated group (P<0.01), especially at 72 h after ischemia-reperfusion. The content of TNF-alpha and IL-1beta at each phase point after ischemia-reperfusion in SA-treated was decreased as compared with that in the untreated group, and there were differences between SA-treated group and untreated group at 72 h after ischemia-reperfusion (P<0.01). An apparent increase was observed in IL-10 between SA-treated group and untreated group at each phase point after ischemia-reperfusion, and there were significant differences between SA-treated group and untreated group at 48 and 72 h after ischemia-reperfusion (P<0.05, P<0.01). CONCLUSION: Scalp acupuncture can improve neurofunctional rehabilitation, suppress leukocyte infiltration, decrease the content of TNF-alpha and IL-1beta within a certain range and enhance IL-10 expression so as to suppress cytokines-mediated inflammatory reaction and attenuate cerebral ischemia-reperfusion injury. SN - 1672-1977 UR - https://www.unboundmedicine.com/medline/citation/17997947/[Effect_of_scalp_acupuncture_on_inflammatory_response_in_rats_with_acute_cerebral_ischemia_reperfusion_injury]_ L2 - https://medlineplus.gov/acupuncture.html DB - PRIME DP - Unbound Medicine ER -