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Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa Rica.
Nat Prod Res. 2008 Jan 10; 22(1):31-6.NP

Abstract

The leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum (Rutaceae) from Monteverde, Costa Rica have been obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. The principal constituents of Z. rhoifolium leaf oil were germacrene D (14.6%), limonene (12.5%), trans-2-hexenal (11.3%), beta-elemene (9.2%), 2-undecanone (9.2%), myrcene (7.9%), bicyclogermacrene (7.5%), and germacrene A (5.2%). The leaf oil of Z. setulosum was composed largely of beta-phellandrene (37.5%), beta-caryophyllene (13.7%), alpha-pinene (11.9%), germacrene D (10.9%), myrcene (5.9%), and nerolidol (5.4%). The essential oils were screened for in-vitro cytotoxic activity against Hep G2, MCF-7, and PC-3 human tumor cell lines; antibacterial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli; and for Artemia salina (brine shrimp) lethality. Neither Z. rhoifolium nor Z. setulosum leaf oils exhibited cytotoxicity or antibacterial activity. Both oils showed activity against A. salina.

Authors+Show Affiliations

Boehme AK
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
Noletto JA
No affiliation info available
Haber WA
No affiliation info available
Setzer WN
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsAntineoplastic AgentsArtemiaBacteriaCell Line, TumorCosta RicaHumansOils, VolatilePlant LeavesPlant OilsZanthoxylum

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17999336

Citation

Boehme, Amelia K., et al. "Bioactivity and Chemical Composition of the Leaf Essential Oils of Zanthoxylum Rhoifolium and Zanthoxylum Setulosum From Monteverde, Costa Rica." Natural Product Research, vol. 22, no. 1, 2008, pp. 31-6.
Boehme AK, Noletto JA, Haber WA, et al. Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa Rica. Nat Prod Res. 2008;22(1):31-6.
Boehme, A. K., Noletto, J. A., Haber, W. A., & Setzer, W. N. (2008). Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa Rica. Natural Product Research, 22(1), 31-6.
Boehme AK, et al. Bioactivity and Chemical Composition of the Leaf Essential Oils of Zanthoxylum Rhoifolium and Zanthoxylum Setulosum From Monteverde, Costa Rica. Nat Prod Res. 2008 Jan 10;22(1):31-6. PubMed PMID: 17999336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa Rica. AU - Boehme,Amelia K, AU - Noletto,Joseph A, AU - Haber,William A, AU - Setzer,William N, PY - 2007/11/14/pubmed PY - 2008/4/25/medline PY - 2007/11/14/entrez SP - 31 EP - 6 JF - Natural product research JO - Nat Prod Res VL - 22 IS - 1 N2 - The leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum (Rutaceae) from Monteverde, Costa Rica have been obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. The principal constituents of Z. rhoifolium leaf oil were germacrene D (14.6%), limonene (12.5%), trans-2-hexenal (11.3%), beta-elemene (9.2%), 2-undecanone (9.2%), myrcene (7.9%), bicyclogermacrene (7.5%), and germacrene A (5.2%). The leaf oil of Z. setulosum was composed largely of beta-phellandrene (37.5%), beta-caryophyllene (13.7%), alpha-pinene (11.9%), germacrene D (10.9%), myrcene (5.9%), and nerolidol (5.4%). The essential oils were screened for in-vitro cytotoxic activity against Hep G2, MCF-7, and PC-3 human tumor cell lines; antibacterial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli; and for Artemia salina (brine shrimp) lethality. Neither Z. rhoifolium nor Z. setulosum leaf oils exhibited cytotoxicity or antibacterial activity. Both oils showed activity against A. salina. SN - 1478-6419 UR - https://www.unboundmedicine.com/medline/citation/17999336/Bioactivity_and_chemical_composition_of_the_leaf_essential_oils_of_Zanthoxylum_rhoifolium_and_Zanthoxylum_setulosum_from_Monteverde_Costa_Rica_ DB - PRIME DP - Unbound Medicine ER -